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Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers.
Volak LP, Hanley MJ, Masse G, Hazarika S, Harmatz JS, Badmaev V, Majeed M, Greenblatt DJ, Court MH. Volak LP, et al. Among authors: court mh. Br J Clin Pharmacol. 2013 Feb;75(2):450-62. doi: 10.1111/j.1365-2125.2012.04364.x. Br J Clin Pharmacol. 2013. PMID: 22725836 Free PMC article. Clinical Trial.
Although curcuminoid and piperine concentrations were readily measured in plasma following glucuronidase/sulfatase treatment, unconjugated concentrations were consistently below the assay thresholds (0.05-0.08 muM and 0.6 muM, respectively). CONCLUSION: The results indicate that …
Although curcuminoid and piperine concentrations were readily measured in plasma following glucuronidase/sulfatase treatment, unconjugated c …
Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase.
Greenblatt DJ, Peters DE, Oleson LE, Harmatz JS, MacNab MW, Berkowitz N, Zinny MA, Court MH. Greenblatt DJ, et al. Among authors: court mh. Br J Clin Pharmacol. 2009 Dec;68(6):920-7. doi: 10.1111/j.1365-2125.2009.03545.x. Br J Clin Pharmacol. 2009. PMID: 20002087 Free PMC article. Clinical Trial.
. * ALT-2074, a catalytic mimic of glutathione oxidase, inhibits human cytochrome P450 3A (CYP3A) isoforms in vitro. WHAT THIS STUDY ADDS: * Short-term administration of low-dose ritonavir increases area under the plasma concentration curve following oral midazolam by a fa …
. * ALT-2074, a catalytic mimic of glutathione oxidase, inhibits human cytochrome P450 3A (CYP3A) isoforms in vitro. WHAT THIS STUDY ADDS: * …
Effects of dietary soy isoflavones on health, steroidogenesis, and thyroid gland function in dogs.
Cerundolo R, Michel KE, Court MH, Shrestha B, Refsal KR, Oliver JW, Biourge V, Shofer FS. Cerundolo R, et al. Among authors: court mh. Am J Vet Res. 2009 Mar;70(3):353-60. doi: 10.2460/ajvr.70.3.353. Am J Vet Res. 2009. PMID: 19254147 Free PMC article. Clinical Trial.
CONCLUSIONS AND CLINICAL RELEVANCE: Phytoestrogens may influence endocrine function in dogs. Feeding soy to dogs on a long-term basis may influence results of studies in which endocrine function is evaluated, although larger studies are needed to confirm this supposition.. …
CONCLUSIONS AND CLINICAL RELEVANCE: Phytoestrogens may influence endocrine function in dogs. Feeding soy to dogs on a long-term basis …
Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem.
Farkas D, Volak LP, Harmatz JS, von Moltke LL, Court MH, Greenblatt DJ. Farkas D, et al. Among authors: court mh. Clin Pharmacol Ther. 2009 Jun;85(6):644-50. doi: 10.1038/clpt.2008.293. Epub 2009 Feb 25. Clin Pharmacol Ther. 2009. PMID: 19242403 Clinical Trial.
However, clarithromycin coadministered with trazodone significantly increased self- and observer-rated sedation and ratings of feeling "spacey." Thus, short-term clarithromycin coadministration significantly impairs trazodone clearance, elevates plasma concentrations, and …
However, clarithromycin coadministered with trazodone significantly increased self- and observer-rated sedation and ratings of feeling "spac …
Nonsteroidal anti-inflammatory drugs in cats: a review.
Lascelles BD, Court MH, Hardie EM, Robertson SA. Lascelles BD, et al. Among authors: court mh. Vet Anaesth Analg. 2007 Jul;34(4):228-50. doi: 10.1111/j.1467-2995.2006.00322.x. Epub 2007 Apr 23. Vet Anaesth Analg. 2007. PMID: 17451496 Review.
CONCLUSIONS: Nonsteroidal anti-inflammatory drugs should be used with caution in cats because of their low capacity for hepatic glucuronidation, which is the major mechanism of metabolism and excretion for this category of drugs. However, the evidence presented supports the short …
CONCLUSIONS: Nonsteroidal anti-inflammatory drugs should be used with caution in cats because of their low capacity for hepatic glucuronidat …
Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers.
Hesse LM, Greenblatt DJ, von Moltke LL, Court MH. Hesse LM, et al. Among authors: court mh. J Clin Pharmacol. 2006 May;46(5):567-76. doi: 10.1177/0091270006286981. J Clin Pharmacol. 2006. PMID: 16638740 Clinical Trial.
The only parameters that showed a statistically significant effect were threohydrobupropion area under the blood concentration curve (14% +/- 5% decrease, mean +/- SE; P = .04) and erythrohydrobupropion time-to-maximal serum concentration (161% +/- 92% increase, P = .03), suggest …
The only parameters that showed a statistically significant effect were threohydrobupropion area under the blood concentration curve (14% +/ …
Identification and concentration of soy phytoestrogens in commercial dog foods.
Cerundolo R, Court MH, Hao Q, Michel KE. Cerundolo R, et al. Among authors: court mh. Am J Vet Res. 2004 May;65(5):592-6. doi: 10.2460/ajvr.2004.65.592. Am J Vet Res. 2004. PMID: 15141878 Free article.
Our results indicated that certain commercial dog foods contain phytoestrogens in amounts that could have biological effects when ingested long-term....
Our results indicated that certain commercial dog foods contain phytoestrogens in amounts that could have biological effects when ingested l …
Effect of dietary soy on serum thyroid hormone concentrations in healthy adult cats.
White HL, Freeman LM, Mahony O, Graham PA, Hao Q, Court MH. White HL, et al. Among authors: court mh. Am J Vet Res. 2004 May;65(5):586-91. doi: 10.2460/ajvr.2004.65.586. Am J Vet Res. 2004. PMID: 15141877 Free article.
OBJECTIVE: To compare effects of short-term administration of a soy diet with those of a soy-free diet on serum thyroid hormone concentrations in healthy adult cats. ...There was no significant effect of diet on any other measured parameter. CONCLUSIONS AND CLINICAL RELEVA …
OBJECTIVE: To compare effects of short-term administration of a soy diet with those of a soy-free diet on serum thyroid hormone conce …
Use of rocuronium for endotracheal intubation of North American Gulf Coast box turtles.
Kaufman GE, Seymour RE, Bonner BB, Court MH, Karas AZ. Kaufman GE, et al. Among authors: court mh. J Am Vet Med Assoc. 2003 Apr 15;222(8):1111-5. doi: 10.2460/javma.2003.222.1111. J Am Vet Med Assoc. 2003. PMID: 12710776 Free article.
OBJECTIVE: To determine whether rocuronium, a reversible neuromuscular blocking agent, would provide safe, short-term immobilization to facilitate endotracheal intubation in turtles. ...
OBJECTIVE: To determine whether rocuronium, a reversible neuromuscular blocking agent, would provide safe, short-term immobilization …
Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.
Court MH, Duan SX, Guillemette C, Journault K, Krishnaswamy S, Von Moltke LL, Greenblatt DJ. Court MH, et al. Drug Metab Dispos. 2002 Nov;30(11):1257-65. doi: 10.1124/dmd.30.11.1257. Drug Metab Dispos. 2002. PMID: 12386133
The aim of the present study was to identify UDP-glucuronosyltransferase (UGT) isoforms mediating R- and S-oxazepam glucuronidation in human liver, with the long term objective of elucidating the molecular genetic basis for this drug metabolism polymorphism. ...
The aim of the present study was to identify UDP-glucuronosyltransferase (UGT) isoforms mediating R- and S-oxazepam glucuronidation in human …
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