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Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs).
Chung MK, House JS, Akhtari FS, Makris KC, Langston MA, Islam KT, Holmes P, Chadeau-Hyam M, Smirnov AI, Du X, Thessen AE, Cui Y, Zhang K, Manrai AK, Motsinger-Reif A, Patel CJ; Members of the Exposomics Consortium. Chung MK, et al. Exposome. 2024 Jan 17;4(1):osae001. doi: 10.1093/exposome/osae001. eCollection 2024. Exposome. 2024. PMID: 38344436 Free PMC article.
Here, we introduce the exposome-wide association study (ExWAS), an approach designed for systematic discovery of relationships between phenotypes and various exposures, identifying significant associations while controlling for multiple comparisons. We advocate for the standardiz …
Here, we introduce the exposome-wide association study (ExWAS), an approach designed for systematic discovery of relationships between pheno …
Changes in pulmonary function following thoracic spine manipulation in a healthy inactive older adult population-a pilot study.
Jonely H, Jayaseelan D, Costello E, Signorino J, Wooten L, Murray D, Woolstenhulme J. Jonely H, et al. Among authors: costello e. J Phys Ther Sci. 2023 Jul;35(7):492-496. doi: 10.1589/jpts.35.492. Epub 2023 Jul 1. J Phys Ther Sci. 2023. PMID: 37405180 Free PMC article.
Few studies have systematically examined non-pharmacologic approaches such as joint manipulation effects on pulmonary function. This study examined the immediate and short-term effects of thoracic manipulation on pulmonary function. [Participants and Methods] Twenty-one ph …
Few studies have systematically examined non-pharmacologic approaches such as joint manipulation effects on pulmonary function. This study e …
Long-term Outcomes of Childhood Family Income Supplements on Adult Functioning.
Copeland WE, Tong G, Gaydosh L, Hill SN, Godwin J, Shanahan L, Costello EJ. Copeland WE, et al. Among authors: costello ej. JAMA Pediatr. 2022 Oct 1;176(10):1020-1026. doi: 10.1001/jamapediatrics.2022.2946. JAMA Pediatr. 2022. PMID: 35994270 Free PMC article.
The children in this study are now adults. OBJECTIVE: To assess the long-term outcomes of family income supplements received in childhood. ...
The children in this study are now adults. OBJECTIVE: To assess the long-term outcomes of family income supplements received in child …
Prior National Drug Abuse Treatment Clinical Trials Network (CTN) opioid use disorder trials as background and rationale for NIDA CTN-0100 "optimizing retention, duration and discontinuation strategies for opioid use disorder pharmacotherapy (RDD)".
Shulman M, Weiss R, Rotrosen J, Novo P, Costello E, Nunes EV. Shulman M, et al. Among authors: costello e. Addict Sci Clin Pract. 2021 Mar 6;16(1):15. doi: 10.1186/s13722-021-00223-z. Addict Sci Clin Pract. 2021. PMID: 33676577 Free PMC article. Review.
Trials on comparative effectiveness of medications for opioid use disorder (MOUD) (CTN-0027; CTN-0030; and CTN-0051) highlighted the problem of dropout from treatment and few trials defined retention on MOUD as the primary outcome. Long-term follow-up studies on those pati …
Trials on comparative effectiveness of medications for opioid use disorder (MOUD) (CTN-0027; CTN-0030; and CTN-0051) highlighted the problem …
Associations of Despair With Suicidality and Substance Misuse Among Young Adults.
Copeland WE, Gaydosh L, Hill SN, Godwin J, Harris KM, Costello EJ, Shanahan L. Copeland WE, et al. Among authors: costello ej. JAMA Netw Open. 2020 Jun 1;3(6):e208627. doi: 10.1001/jamanetworkopen.2020.8627. JAMA Netw Open. 2020. PMID: 32573708 Free PMC article.
IMPORTANCE: Deaths of despair is a term that has recently been used to describe the increases in premature mortality from suicides, drug overdoses (particularly from opiates), and alcohol-related liver disease among US adults. Despite the use of the term despair, it …
IMPORTANCE: Deaths of despair is a term that has recently been used to describe the increases in premature mortality from suicides, d …
Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment.
Singh P, Brown R, Copeland WE, Costello EJ, Bruckner TA. Singh P, et al. Among authors: costello ej. Biodemography Soc Biol. 2020 Apr-Jun;65(2):172-187. doi: 10.1080/19485565.2020.1730155. Biodemography Soc Biol. 2020. PMID: 32432936 Free PMC article.
The large magnitude of this result among EBCI men indicates that a non-trivial cash dividend to a low-income population may confer long-term benefits on perceptions of future lifespan and, in turn, reduce temporal discounting.Abbreviations: EBCI: Eastern Band of Cherokee I …
The large magnitude of this result among EBCI men indicates that a non-trivial cash dividend to a low-income population may confer long-t …
Children and families of the opioid epidemic: Under the radar.
Stulac S, Bair-Merritt M, Wachman EM, Augustyn M, Howard C, Madoor N, Costello E. Stulac S, et al. Among authors: costello e. Curr Probl Pediatr Adolesc Health Care. 2019 Aug;49(8):100637. doi: 10.1016/j.cppeds.2019.07.002. Epub 2019 Sep 5. Curr Probl Pediatr Adolesc Health Care. 2019. PMID: 31494050
As increasing resources are now being directed towards addressing the growing U.S. opioid epidemic, the long-term care of children from opioid-affected families has been relatively neglected. While an array of evidence suggests long-term negative developmental, medi …
As increasing resources are now being directed towards addressing the growing U.S. opioid epidemic, the long-term care of children fr …
Does Despair Really Kill? A Roadmap for an Evidence-Based Answer.
Shanahan L, Hill SN, Gaydosh LM, Steinhoff A, Costello EJ, Dodge KA, Harris KM, Copeland WE. Shanahan L, et al. Among authors: costello ej. Am J Public Health. 2019 Jun;109(6):854-858. doi: 10.2105/AJPH.2019.305016. Epub 2019 Apr 18. Am J Public Health. 2019. PMID: 30998413 Free PMC article.
Economists interpret these population-level trends to indicate that despair induced by financial stressors is a shared pathway to these causes of death. Although we now have the catchy term "deaths of despair," we have yet to study its central empirical claim: that concept …
Economists interpret these population-level trends to indicate that despair induced by financial stressors is a shared pathway to these caus …
Association of Childhood Trauma Exposure With Adult Psychiatric Disorders and Functional Outcomes.
Copeland WE, Shanahan L, Hinesley J, Chan RF, Aberg KA, Fairbank JA, van den Oord EJCG, Costello EJ. Copeland WE, et al. Among authors: costello ej. JAMA Netw Open. 2018 Nov 2;1(7):e184493. doi: 10.1001/jamanetworkopen.2018.4493. JAMA Netw Open. 2018. PMID: 30646356 Free PMC article.
Childhood trauma exposures are common, but often preventable, thus providing a clear target for child-focused public health efforts to ameliorate long-term morbidity....
Childhood trauma exposures are common, but often preventable, thus providing a clear target for child-focused public health efforts to ameli …
37 results