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Microglial polarization differentially affects neuronal vulnerability to the β-amyloid protein: Modulation by melatonin.
Merlo S, Caruso GI, Bonfili L, Spampinato SF, Costantino G, Eleuteri AM, Sortino MA. Merlo S, et al. Among authors: costantino g. Biochem Pharmacol. 2022 Aug;202:115151. doi: 10.1016/j.bcp.2022.115151. Epub 2022 Jun 22. Biochem Pharmacol. 2022. PMID: 35750198
In addition, MEL partially restored proteasome functionality that was altered by long-term Abeta42 treatment, re-establishing both 20S and 26S chymotrypsin-like activity. ...
In addition, MEL partially restored proteasome functionality that was altered by long-term Abeta42 treatment, re-establishing both 20 …
A Systematic Review on Intensity Modulated Radiation Therapy for Mediastinal Hodgkin's Lymphoma.
Buglione M, Guerini AE, Filippi AR, Spiazzi L, Pasinetti N, Magli A, Toraci C, Borghetti P, Triggiani L, Alghisi A, Costantino G, Bertagna F, Giaj Levra N, Pegurri L, Magrini SM. Buglione M, et al. Among authors: costantino g. Crit Rev Oncol Hematol. 2021 Nov;167:103437. doi: 10.1016/j.critrevonc.2021.103437. Epub 2021 Aug 3. Crit Rev Oncol Hematol. 2021. PMID: 34358649 Review.
Conformal radiotherapy techniques such as Intensity-Modulated Radiation Therapy (IMRT) could allow a reduction of the dose to the organs-at-risk (OARs) and therefore limit long-term toxicity. METHODS: We performed a systematic review of the current literature regarding com …
Conformal radiotherapy techniques such as Intensity-Modulated Radiation Therapy (IMRT) could allow a reduction of the dose to the organs-at- …
Mortality in Patients with COVID-19 on Renin Angiotensin System Inhibitor Long-Term Treatment: An Observational Study Showing that Things Are Not Always as They Seem.
Cugno M, Gualtierotti R, Casazza G, Tafuri F, Ghigliazza G, Torri A, Costantino G, Montano N, Peyvandi F. Cugno M, et al. Among authors: costantino g. Adv Ther. 2021 May;38(5):2709-2716. doi: 10.1007/s12325-021-01704-y. Epub 2021 Apr 1. Adv Ther. 2021. PMID: 33792889 Free PMC article.
CONCLUSION: The apparently increased mortality of patients with COVID-19 receiving long-term treatment with ACE inhibitors or ARBs is not due to the drugs themselves, but to the conditions associated with their use....
CONCLUSION: The apparently increased mortality of patients with COVID-19 receiving long-term treatment with ACE inhibitors or ARBs is …
Nabiximols discontinuation rate in a large population of patients with multiple sclerosis: a 18-month multicentre study.
Chisari CG, Solaro C, Annunziata P, Bergamaschi R, Bianco A, Bonavita S, Brescia Morra V, Bruno Bossio R, Capello E, Castelli L, Cavalla P, Costantino G, Centonze D, Cottone S, Danni MC, Esposito F, Gajofatto A, Gasperini C, Guareschi A, Lanzillo R, Lus G, Maniscalco GT, Matta M, Paolicelli D, Petrucci L, Pontecorvo S, Righini I, Rovaris M, Sessa E, Spinicci G, Spitaleri D, Valentino P, Zaffaroni M, Zappia M, Patti F. Chisari CG, et al. Among authors: costantino g. J Neurol Neurosurg Psychiatry. 2020 Sep;91(9):914-920. doi: 10.1136/jnnp-2019-322480. Epub 2020 Jul 13. J Neurol Neurosurg Psychiatry. 2020. PMID: 32661083
INTRODUCTION: Delta-delta-tetrahydrocannabinol and cannabidiol (THC:CBD) oromucosal spray is used as an add-on therapy option for moderate to severe multiple sclerosis (MS) spasticity resistant to other medications. Aims of this study were to provide real-life data on long-ter …
INTRODUCTION: Delta-delta-tetrahydrocannabinol and cannabidiol (THC:CBD) oromucosal spray is used as an add-on therapy option for moderate t …
Short vs long-course antibiotic therapy in pyelonephritis: a comparison of systematic reviews and guidelines for the SIMI choosing wisely campaign.
Erba L, Furlan L, Monti A, Marsala E, Cernuschi G, Solbiati M, Bracco C, Bandini G, Pecorino Meli M, Casazza G, Montano N, Sbrojavacca R, Costantino G. Erba L, et al. Among authors: costantino g. Intern Emerg Med. 2021 Mar;16(2):313-323. doi: 10.1007/s11739-020-02401-4. Epub 2020 Jun 21. Intern Emerg Med. 2021. PMID: 32566969
BACKGROUND: The Italian Society of Internal Medicine (SIMI) Choosing Wisely Campaign has recently proposed, among its five items, to reduce the prescription of long-term intravenous antibiotics if not indicated. The aim of our study was to assess the available evidences on …
BACKGROUND: The Italian Society of Internal Medicine (SIMI) Choosing Wisely Campaign has recently proposed, among its five items, to reduce …
Real-Life Effectiveness and Safety of Golimumab and Its Predictors of Response in Patients with Ulcerative Colitis.
Bossa F, Biscaglia G, Valvano MR, Costantino G, Lauria A, Clemente R, Ferracane C, Shahini E, Mendolaro M, Grossi L, Mazzuoli S, Rispo A, Pranzo G, Sebkova L, Tursi A, Miranda A, Patturelli M, Spagnuolo R, Ricciardelli C, Sgarro C, Paese P, Inserra G, Azzarone A, Nardone O, Fries W, Buccianti N, Privitera AC, Principi MB, Cappello M, Guglielmi FW, Romano M, Riegler G, Fanigliulo L, Melina R, Andriulli A. Bossa F, et al. Among authors: costantino g. Dig Dis Sci. 2020 Jun;65(6):1767-1776. doi: 10.1007/s10620-019-05904-z. Epub 2019 Nov 13. Dig Dis Sci. 2020. PMID: 31722059
BACKGROUND: Golimumab is a new anti-TNF-alpha monoclonal antibody for patients with ulcerative colitis. AIMS: To assess the short- and long-term effectiveness and safety of golimumab in daily clinical practice and to identify predictors of response. ...CONCLUSIONS: The eff …
BACKGROUND: Golimumab is a new anti-TNF-alpha monoclonal antibody for patients with ulcerative colitis. AIMS: To assess the short- and long- …
The Italian multiple sclerosis register.
Trojano M, Bergamaschi R, Amato MP, Comi G, Ghezzi A, Lepore V, Marrosu MG, Mosconi P, Patti F, Ponzio M, Zaratin P, Battaglia MA; Italian Multiple Sclerosis Register Centers Group. Trojano M, et al. Neurol Sci. 2019 Jan;40(1):155-165. doi: 10.1007/s10072-018-3610-0. Epub 2018 Nov 13. Neurol Sci. 2019. PMID: 30426289 Free PMC article.
MS registries represent powerful tools to provide meaningful information on the burden, natural history, and long-term safety and effectiveness of treatments. Moreover, patients, physicians, industry, and policy makers have an active interest in real-world observational st …
MS registries represent powerful tools to provide meaningful information on the burden, natural history, and long-term safety and eff …
Artificial neural networks and risk stratification in emergency departments.
Falavigna G, Costantino G, Furlan R, Quinn JV, Ungar A, Ippoliti R. Falavigna G, et al. Among authors: costantino g. Intern Emerg Med. 2019 Mar;14(2):291-299. doi: 10.1007/s11739-018-1971-2. Epub 2018 Oct 23. Intern Emerg Med. 2019. PMID: 30353271
Analyzing a sample of 1844 patients and focusing on the decision to hospitalize a patient after a syncope event to prevent severe short-term outcomes, this work proposes a new algorithm based on neural networks. Artificial neural networks are a non-parametric technique wit …
Analyzing a sample of 1844 patients and focusing on the decision to hospitalize a patient after a syncope event to prevent severe short-t …
Long-term follow-up of pediatric MS patients starting treatment with injectable first-line agents: A multicentre, Italian, retrospective, observational study.
Baroncini D, Zaffaroni M, Moiola L, Lorefice L, Fenu G, Iaffaldano P, Simone M, Fanelli F, Patti F, D'Amico E, Capobianco M, Bertolotto A, Gallo P, Margoni M, Miante S, Milani N, Amato MP, Righini I, Bellantonio P, Scandellari C, Costantino G, Scarpini E, Bergamaschi R, Mallucci G, Comi G, Ghezzi A. Baroncini D, et al. Among authors: costantino g. Mult Scler. 2019 Mar;25(3):399-407. doi: 10.1177/1352458518754364. Epub 2018 Jan 24. Mult Scler. 2019. PMID: 29363396
BACKGROUND: Few data are available on very long-term follow-up of pediatric multiple sclerosis (MS) patients treated with disease modifying treatments (DMTs). OBJECTIVES: To present a long-term follow-up of a cohort of Pediatric-MS patients starting injectable first …
BACKGROUND: Few data are available on very long-term follow-up of pediatric multiple sclerosis (MS) patients treated with disease mod …
40 results