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De Novo Generation of Somatic Stem Cells by YAP/TAZ.
Panciera T, Azzolin L, Di Biagio D, Totaro A, Cordenonsi M, Piccolo S. Panciera T, et al. Among authors: cordenonsi m. J Vis Exp. 2018 May 7;(135):57462. doi: 10.3791/57462. J Vis Exp. 2018. PMID: 29782008 Free PMC article.
Similarly, to endogenous, natural SCs, YAP-induced stem-like cells ("ySCs") can be eventually expanded as organoid cultures long term in vitro, without further need of ectopic YAP/TAZ, as ySCs are endowed with a heritable self-renewing SC-like state. ...
Similarly, to endogenous, natural SCs, YAP-induced stem-like cells ("ySCs") can be eventually expanded as organoid cultures long term …