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Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells.
Lv L, Zhang T, Yi Q, Huang Y, Wang Z, Hou H, Zhang H, Zheng W, Hao Q, Guo Z, Cooke HJ, Shi Q. Lv L, et al. Among authors: cooke hj. Cell Cycle. 2012 Aug 1;11(15):2864-75. doi: 10.4161/cc.21196. Epub 2012 Aug 1. Cell Cycle. 2012. PMID: 22801546 Free PMC article.
In the present study, cytogenetic analyses of a mouse syngeneic ovarian cancer model revealed that diploid mouse ovarian surface epithelial cells (MOSECs) experienced an intermediate tetraploid cell stage, before evolving to aneuploid (mainly near-tetraploid) cells. Using long- …
In the present study, cytogenetic analyses of a mouse syngeneic ovarian cancer model revealed that diploid mouse ovarian surface epithelial …
Rapid proliferation of daughter cells lacking particular chromosomes due to multipolar mitosis promotes clonal evolution in colorectal cancer cells.
Yang C, Shi X, Huang Y, Zhang Z, Cooke HJ, Wang M, Shi Q. Yang C, et al. Among authors: cooke hj. Cell Cycle. 2012 Jul 15;11(14):2650-9. doi: 10.4161/cc.20976. Epub 2012 Jul 15. Cell Cycle. 2012. PMID: 22732493
By using fluorescence in situ hybridization (FISH) on cells after long-term live cell imaging, we demonstrated that most (> 90%) of the newly generated aneuploid cells resulted from multipolar divisions. ...
By using fluorescence in situ hybridization (FISH) on cells after long-term live cell imaging, we demonstrated that most (> 90%) o …
Histamine receptors on submucous neurons in guinea pig colon.
Frieling T, Cooke HJ, Wood JD. Frieling T, et al. Among authors: cooke hj. Am J Physiol. 1993 Jan;264(1 Pt 1):G74-80. doi: 10.1152/ajpgi.1993.264.1.G74. Am J Physiol. 1993. PMID: 8430807
The second was presynaptic suppression of acetylcholine release at nicotinic synapses. The third occurred during long-term application and consisted of recurrent trains of action potentials associated with periodic depolarization of membrane potential. ...
The second was presynaptic suppression of acetylcholine release at nicotinic synapses. The third occurred during long-term applicatio …
Effect of hibernation and jejunal bypass on mucosal structure and function.
Carey HV, Cooke HJ. Carey HV, et al. Among authors: cooke hj. Am J Physiol. 1991 Jul;261(1 Pt 1):G37-44. doi: 10.1152/ajpgi.1991.261.1.G37. Am J Physiol. 1991. PMID: 1858887
This study compared the relative effects of these factors in an animal model that undergoes seasonal long-term fasting. Jejunal bypass operations or sham surgeries were performed on active fed ground squirrels or on squirrels that subsequently ceased feeding and hibernated …
This study compared the relative effects of these factors in an animal model that undergoes seasonal long-term fasting. Jejunal bypas …