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Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease.
Mei X, Blanchard J, Luellen C, Conboy MJ, Conboy IM. Mei X, et al. Among authors: conboy im. Aging (Albany NY). 2023 Sep 12;15(17):8552-8575. doi: 10.18632/aging.205046. Epub 2023 Sep 12. Aging (Albany NY). 2023. PMID: 37702598 Free PMC article.
We established that dysregulation of such cytosines, measured as the sums of standard deviations of their methylation values, quantifies biological noise, which in our hypothesis is a biomarker of aging and disease. We term this approach a "noise barometer" - the pressure …
We established that dysregulation of such cytosines, measured as the sums of standard deviations of their methylation values, quantifies bio …