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Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
Long-acting bronchodilators in cystic fibrosis.
Colombo JL. Colombo JL. Curr Opin Pulm Med. 2003 Nov;9(6):504-8. doi: 10.1097/00063198-200311000-00010. Curr Opin Pulm Med. 2003. PMID: 14534403 Review.
SUMMARY: In spite of the widespread use of bronchodilators, there are very few long-term studies of their effects in CF patients. However, there are clearly clinical benefits in certain situations. ...
SUMMARY: In spite of the widespread use of bronchodilators, there are very few long-term studies of their effects in CF patients. How …
Effectiveness and tolerability of high-dose salmeterol in cystic fibrosis.
Hordvik NL, Sammut PH, Judy CG, Colombo JL. Hordvik NL, et al. Among authors: colombo jl. Pediatr Pulmonol. 2002 Oct;34(4):287-96. doi: 10.1002/ppul.10162. Pediatr Pulmonol. 2002. PMID: 12205570 Clinical Trial.
Tolerability was evaluated by changes in vital signs and adverse events.Thirty-six out of 44 patients enrolled finished the short-term treatment period, and 19 out of 23 who continued the study also finished the long-term treatment period. ...Also, there were more a …
Tolerability was evaluated by changes in vital signs and adverse events.Thirty-six out of 44 patients enrolled finished the short-term …
Unusual form of endobronchial Aspergillosis in a patient with cystic fibrosis.
Sammut PH, Howard ST, Linder J, Colombo JL. Sammut PH, et al. Among authors: colombo jl. Pediatr Pulmonol. 1993 Jul;16(1):69-73. doi: 10.1002/ppul.1950160114. Pediatr Pulmonol. 1993. PMID: 8414745
No improvement was seen with a 3 week course of systemic corticosteroid and antibiotic therapy. Treatment with amphotericin B and short-term mechanical ventilation resulted in rapid resolution of all symptoms. ...
No improvement was seen with a 3 week course of systemic corticosteroid and antibiotic therapy. Treatment with amphotericin B and short-t …
Circulating immune complexes in cystic fibrosis and their correlation to clinical parameters.
Disis ML, McDonald TL, Colombo JL, Kobayashi RH, Angle CR, Murray S. Disis ML, et al. Among authors: colombo jl. Pediatr Res. 1986 May;20(5):385-90. doi: 10.1203/00006450-198605000-00002. Pediatr Res. 1986. PMID: 3714348
These data suggest that CICs cannot be used as an indication of short-term prognosis or as a monitor to follow the course of acute severe lung infections in the CF patient. ...
These data suggest that CICs cannot be used as an indication of short-term prognosis or as a monitor to follow the course of acute se …