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Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model.
Coles LD, Saletti PG, Lisgaras CP, Casillas-Espinosa PM, Liu W, Li Q, Jones NC, Shultz S, Ali I, Brady R, Yamakawa G, Hudson M, Silva J, Braine E, Mishra U, Cloyd JC, O'Brien TJ, Moshé SL, Galanopoulou AS; EpiBioS4Rx Study Group. Coles LD, et al. J Pharmacol Exp Ther. 2023 Aug;386(2):259-265. doi: 10.1124/jpet.122.001377. Epub 2023 Jun 14. J Pharmacol Exp Ther. 2023. PMID: 37316328 Free PMC article.
The single-dose pharmacokinetic data were used to guide dose selection for the longer-term studies, and target drug exposures were confirmed. Obtaining LEV PK information early in the screening phase allowed us to guide optimal treatment protocols in EpiBioS4Rx. ...
The single-dose pharmacokinetic data were used to guide dose selection for the longer-term studies, and target drug exposures were co …
Demographics of human supercentenarians and the implications for longevity medicine.
Coles LS. Coles LS. Ann N Y Acad Sci. 2004 Jun;1019:490-5. doi: 10.1196/annals.1297.090. Ann N Y Acad Sci. 2004. PMID: 15247072 Review.
The Gerontology Research Group, affiliated with the UCLA School of Medicine, has compiled and maintained a Table of Worldwide Living Supercentenarians (persons 110 years or older) for the last 4 years, shedding important light on the biological limits of human morbidity and morta …
The Gerontology Research Group, affiliated with the UCLA School of Medicine, has compiled and maintained a Table of Worldwide Living Superce …
Prevention of physical child abuse: concept, evidence and practice.
Coles L. Coles L. Community Pract. 2008 Jun;81(6):18-22. Community Pract. 2008. PMID: 18672856 Review.
This paper reflects on knowledge gained while undertaking case series research into non-accidental head injury (NAHI), qualitative research with health visitors and mothers and fathers into the feasibility of preventing NAHI, and work as a team member of the Welsh Child Protectio …
This paper reflects on knowledge gained while undertaking case series research into non-accidental head injury (NAHI), qualitative research …
Identifying Biological Signatures of N-Acetylcysteine for Non-Suicidal Self-Injury in Adolescents and Young Adults.
Sahasrabudhe SA, Silamongkol T, Park YW, Colette A, Eberly LE, Klimes-Dougan B, Coles LD, Cloyd JC, Öz G, Mueller BA, Kartha RV, Cullen KR. Sahasrabudhe SA, et al. Among authors: coles ld. J Psychiatr Brain Sci. 2021;6:e210007. doi: 10.20900/jpbs.20210007. Epub 2021 Apr 29. J Psychiatr Brain Sci. 2021. PMID: 34036177 Free PMC article.
The first stage; a double-blind randomized placebo-controlled study will focus on identifying the optimal dose to achieve meaningful change in GSH and Glu during short-term (4 weeks) NAC treatment in 36 women aged 16-24 years with NSSI. ...
The first stage; a double-blind randomized placebo-controlled study will focus on identifying the optimal dose to achieve meaningful change …
Effect of a low dose whey/guar preload on glycemic control in people with type 2 diabetes--a randomised controlled trial.
Clifton PM, Galbraith C, Coles L. Clifton PM, et al. Among authors: coles l. Nutr J. 2014 Oct 25;13:103. doi: 10.1186/1475-2891-13-103. Nutr J. 2014. PMID: 25343850 Free PMC article. Clinical Trial.
CONCLUSIONS: An 80 kcal whey protein/fibre preload can lower average glucose over 3 hours by 0.8 mmol/L. If used long term before at least two carbohydrate-rich meals/day this preload could lower HbA1c by up to 1%. ...
CONCLUSIONS: An 80 kcal whey protein/fibre preload can lower average glucose over 3 hours by 0.8 mmol/L. If used long term before at …