Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model.
Coles LD, Saletti PG, Lisgaras CP, Casillas-Espinosa PM, Liu W, Li Q, Jones NC, Shultz S, Ali I, Brady R, Yamakawa G, Hudson M, Silva J, Braine E, Mishra U, Cloyd JC, O'Brien TJ, Moshé SL, Galanopoulou AS; EpiBioS4Rx Study Group.
Coles LD, et al.
J Pharmacol Exp Ther. 2023 Aug;386(2):259-265. doi: 10.1124/jpet.122.001377. Epub 2023 Jun 14.
J Pharmacol Exp Ther. 2023.
PMID: 37316328
Free PMC article.
The single-dose pharmacokinetic data were used to guide dose selection for the longer-term studies, and target drug exposures were confirmed. Obtaining LEV PK information early in the screening phase allowed us to guide optimal treatment protocols in EpiBioS4Rx. ...
The single-dose pharmacokinetic data were used to guide dose selection for the longer-term studies, and target drug exposures were co …