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Evolution is driven by natural autoencoding: reframing species, interaction codes, cooperation and sexual reproduction.
Cohen IR, Marron A. Cohen IR, et al. Proc Biol Sci. 2023 Mar 8;290(1994):20222409. doi: 10.1098/rspb.2022.2409. Epub 2023 Mar 1. Proc Biol Sci. 2023. PMID: 36855872 Free PMC article.
The continuity of life and its evolution, we proposed, emerge from an interactive group process manifested in networks of interaction. We term this process survival of the fitted. Here, we reason that survival of the fitted results from a natural computational process we …
The continuity of life and its evolution, we proposed, emerge from an interactive group process manifested in networks of interaction. We …
The evolution of universal adaptations of life is driven by universal properties of matter: energy, entropy, and interaction.
Cohen IR, Marron A. Cohen IR, et al. F1000Res. 2020 Jun 18;9:626. doi: 10.12688/f1000research.24447.3. eCollection 2020. F1000Res. 2020. PMID: 32802320 Free PMC article.
Metabolic networks channel some of this energy to form cooperating, interactive arrangements. Entropy, used here as a term for all forces that dismantle ordered structures (rather than as a physical quantity), acts as a selective force. ...
Metabolic networks channel some of this energy to form cooperating, interactive arrangements. Entropy, used here as a term for all fo …
Activation of the Akt-CREB signalling axis by a proline-rich heptapeptide confers resistance to stress-induced cell death and inflammation.
Herkel J, Schrader J, Erez N, Lohse AW, Cohen IR. Herkel J, et al. Among authors: cohen ir. Immunology. 2017 Aug;151(4):474-480. doi: 10.1111/imm.12745. Epub 2017 May 16. Immunology. 2017. PMID: 28419468 Free PMC article.
To that end, we developed a synthetic peptide of seven amino acids based on structural mimicry to a functional domain of p53, a key factor in the responses of cells to stressful stimuli. This heptapeptide, which we term Stressin-1, was found to inhibit both cell death and …
To that end, we developed a synthetic peptide of seven amino acids based on structural mimicry to a functional domain of p53, a key factor i …
Tumor-associated and disease-associated autoantibody repertoires in healthy colostrum and maternal and newborn cord sera.
Madi A, Bransburg-Zabary S, Maayan-Metzger A, Dar G, Ben-Jacob E, Cohen IR. Madi A, et al. Among authors: cohen ir. J Immunol. 2015 Jun 1;194(11):5272-81. doi: 10.4049/jimmunol.1402771. Epub 2015 Apr 27. J Immunol. 2015. PMID: 25917091 Free PMC article.
In this work, we studied autoantibody repertoires and Ig isotypes in 71 mothers and their 104 healthy newborns (including twins and triplets delivered term or premature). Newborns receive maternal IgG Abs via the placenta before birth, but developing infants must pr …
In this work, we studied autoantibody repertoires and Ig isotypes in 71 mothers and their 104 healthy newborns (including twins and triplets …
Evaluation of long-term treatment effect in a type 1 diabetes intervention trial: differences after stimulation with glucagon or a mixed meal.
Pozzilli P, Raz I, Peled D, Elias D, Avron A, Tamir M, Eren R, Dagan S, Cohen IR. Pozzilli P, et al. Among authors: cohen ir. Diabetes Care. 2014;37(5):1384-91. doi: 10.2337/dc13-1392. Epub 2014 Jan 9. Diabetes Care. 2014. PMID: 24408401 Retracted. Clinical Trial.
This study compares these two stimulation methods using long-term data from patients newly diagnosed with type 1 diabetes or with latent autoimmune diabetes. ...Pearson's correlations were calculated for absolute C-peptide AUC at baseline and 12 and 24 months and for long- …
This study compares these two stimulation methods using long-term data from patients newly diagnosed with type 1 diabetes or with lat …
Split immunity: immune inhibition of rat gliomas by subcutaneous exposure to unmodified live tumor cells.
Volovitz I, Marmor Y, Azulay M, Machlenkin A, Goldberger O, Mor F, Slavin S, Ram Z, Cohen IR, Eisenbach L. Volovitz I, et al. Among authors: cohen ir. J Immunol. 2011 Nov 15;187(10):5452-62. doi: 10.4049/jimmunol.1003946. Epub 2011 Oct 12. J Immunol. 2011. PMID: 21998458
We propose in this study a location-based immunotherapeutic phenomenon we term "split immunity": a tumor that thrives in an immune-privileged site may be inhibited by injecting live, unmodified tumor cells into a site that is not privileged, generating protective immunity …
We propose in this study a location-based immunotherapeutic phenomenon we term "split immunity": a tumor that thrives in an immune-pr …
Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.
Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Madi A, et al. Among authors: cohen ir. PLoS One. 2011 Mar 8;6(3):e17445. doi: 10.1371/journal.pone.0017445. PLoS One. 2011. PMID: 21408156 Free PMC article.
This analysis makes possible the characterization and comparison of the IgG and IgM immune networks at birth (newborns) and adulthood (mothers) in terms of topology and node importance. ...Inspection of the antigen importance revealed some dominant (in terms of high centra …
This analysis makes possible the characterization and comparison of the IgG and IgM immune networks at birth (newborns) and adulthood …
An antibody profile of systemic lupus erythematosus detected by antigen microarray.
Fattal I, Shental N, Mevorach D, Anaya JM, Livneh A, Langevitz P, Zandman-Goddard G, Pauzner R, Lerner M, Blank M, Hincapie ME, Gafter U, Naparstek Y, Shoenfeld Y, Domany E, Cohen IR. Fattal I, et al. Among authors: cohen ir. Immunology. 2010 Jul;130(3):337-43. doi: 10.1111/j.1365-2567.2010.03245.x. Epub 2010 Feb 26. Immunology. 2010. PMID: 20201986 Free PMC article.
The analysis produced two novel findings: (i) an SLE antibody profile persists independently of disease activity and despite long-term clinical remission, and (ii) this SLE antibody profile includes increases in four specific immunoglobulin G (IgG) reactivities to double-s …
The analysis produced two novel findings: (i) an SLE antibody profile persists independently of disease activity and despite long-term …
Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies.
Hagedorn PH, Burton CM, Carlsen J, Steinbrüchel D, Andersen CB, Sahar E, Domany E, Cohen IR, Flyvbjerg H, Iversen M. Hagedorn PH, et al. Among authors: cohen ir. Immunology. 2010 Jul;130(3):427-35. doi: 10.1111/j.1365-2567.2010.03246.x. Epub 2010 Feb 26. Immunology. 2010. PMID: 20201985 Free PMC article.
Obliterative bronchiolitis (OB) continues to be the major limitation to long-term survival after lung transplantation. The specific aetiology and pathogenesis of OB are not well understood. ...
Obliterative bronchiolitis (OB) continues to be the major limitation to long-term survival after lung transplantation. The specific a …
Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conducive.
Cohen N, Stolarsky-Bennun M, Amir-Kroll H, Margalit R, Nussbaum G, Cohen-Sfady M, Pevsner-Fischer M, Fridkin M, Bercovier H, Eisenbach L, Jung S, Cohen IR. Cohen N, et al. Among authors: cohen ir. J Immunol. 2008 Feb 15;180(4):2409-18. doi: 10.4049/jimmunol.180.4.2409. J Immunol. 2008. PMID: 18250450
The injection of macrophages manifesting PS4 on the surface into mice induced long-term resistance to lethal Streptococcus pneumoniae challenge. The TLR4 ligand LPS could also induce the late appearance on the surface of unconjugated PS4 and resistance to challenge in inje …
The injection of macrophages manifesting PS4 on the surface into mice induced long-term resistance to lethal Streptococcus pneumoniae …
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