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The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial.
Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators. Marson A, et al. Lancet. 2021 Apr 10;397(10282):1375-1386. doi: 10.1016/S0140-6736(21)00246-4. Lancet. 2021. PMID: 33838758 Free PMC article. Clinical Trial.
Levetiracetam is increasingly prescribed for these patient populations despite scarcity of evidence of clinical effectiveness or cost-effectiveness. We aimed to compare the long-term clinical effectiveness and cost-effectiveness of levetiracetam compared with valproate in …
Levetiracetam is increasingly prescribed for these patient populations despite scarcity of evidence of clinical effectiveness or cost-effect …
The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial.
Marson A, Burnside G, Appleton R, Smith D, Leach JP, Sills G, Tudur-Smith C, Plumpton C, Hughes DA, Williamson P, Baker GA, Balabanova S, Taylor C, Brown R, Hindley D, Howell S, Maguire M, Mohanraj R, Smith PE; SANAD II collaborators. Marson A, et al. Lancet. 2021 Apr 10;397(10282):1363-1374. doi: 10.1016/S0140-6736(21)00247-6. Lancet. 2021. PMID: 33838757 Free PMC article. Clinical Trial.
BACKGROUND: Levetiracetam and zonisamide are licensed as monotherapy for patients with focal epilepsy, but there is uncertainty as to whether they should be recommended as first-line treatments because of insufficient evidence of clinical effectiveness and cost-effectiveness. We …
BACKGROUND: Levetiracetam and zonisamide are licensed as monotherapy for patients with focal epilepsy, but there is uncertainty as to whethe …
Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study.
Trinka E, Rocamora R, Chaves J, Moreira J, Ikedo F, Soares-da-Silva P; BIA-2093-311/EXT Investigators Study Group. Trinka E, et al. Epilepsia. 2020 Oct;61(10):2129-2141. doi: 10.1111/epi.16666. Epub 2020 Sep 17. Epilepsia. 2020. PMID: 32944934 Free PMC article. Clinical Trial.
OBJECTIVE: To assess the efficacy, safety, and tolerability of eslicarbazepine acetate (ESL) monotherapy during long-term treatment. METHODS: An open-label extension (OLE) study was conducted in adults completing a phase 3, randomized, double-blind, noninferiority trial, d …
OBJECTIVE: To assess the efficacy, safety, and tolerability of eslicarbazepine acetate (ESL) monotherapy during long-term treatment. …
Characteristics associated with quality of life among people with drug-resistant epilepsy.
Ridsdale L, Wojewodka G, Robinson E, Landau S, Noble A, Taylor S, Richardson M, Baker G, Goldstein LH; SMILE Team. Ridsdale L, et al. J Neurol. 2017 Jun;264(6):1174-1184. doi: 10.1007/s00415-017-8512-1. Epub 2017 May 26. J Neurol. 2017. PMID: 28550480 Free PMC article.
Educational courses may not change QoL, but be one component supporting self-management for people with long-term conditions, like epilepsy....
Educational courses may not change QoL, but be one component supporting self-management for people with long-term conditions, like ep …
eLearning resources to supplement postgraduate neurosurgery training.
Stienen MN, Schaller K, Cock H, Lisnic V, Regli L, Thomson S. Stienen MN, et al. Among authors: cock h. Acta Neurochir (Wien). 2017 Feb;159(2):325-337. doi: 10.1007/s00701-016-3042-7. Epub 2016 Dec 5. Acta Neurochir (Wien). 2017. PMID: 27921190
MATERIAL AND METHODS: A MEDLINE query was performed, using the search term "electronic AND learning AND neurosurgery". Only peer-reviewed English-language articles on the use of any means of eLearning to improve theoretical knowledge in postgraduate neurosurgical training …
MATERIAL AND METHODS: A MEDLINE query was performed, using the search term "electronic AND learning AND neurosurgery". Only peer-revi …
Different attachment styles correlate with mood disorders in adults with epilepsy or migraine.
Mula M, Danquah-Boateng D, Cock HR, Khan U, Lozsadi DA, Nirmalananthan N. Mula M, et al. Among authors: cock hr. Epilepsy Behav. 2016 Jan;54:110-4. doi: 10.1016/j.yebeh.2015.11.023. Epub 2015 Dec 17. Epilepsy Behav. 2016. PMID: 26704569 Free article.
PURPOSE: Interpersonal relationships are viewed as important contexts within which psychopathology emerges and persists or desists. Attachment theory describes the dynamics of long-term relationships between humans especially in families and lifelong friendships. ...
PURPOSE: Interpersonal relationships are viewed as important contexts within which psychopathology emerges and persists or desists. Attachme …
A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus.
Trinka E, Cock H, Hesdorffer D, Rossetti AO, Scheffer IE, Shinnar S, Shorvon S, Lowenstein DH. Trinka E, et al. Among authors: cock h. Epilepsia. 2015 Oct;56(10):1515-23. doi: 10.1111/epi.13121. Epub 2015 Sep 4. Epilepsia. 2015. PMID: 26336950 Free article. Review.
The proposed new definition of SE is as follows: Status epilepticus is a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms, which lead to abnormally, prolonged seizures (after time point t1 ). It …
The proposed new definition of SE is as follows: Status epilepticus is a condition resulting either from the failure of the mechanisms respo …
More than seizures: improving the lives of people with refractory epilepsy.
Mula M, Cock HR. Mula M, et al. Among authors: cock hr. Eur J Neurol. 2015 Jan;22(1):24-30. doi: 10.1111/ene.12603. Epub 2014 Nov 4. Eur J Neurol. 2015. PMID: 25367637 Review.
These include mood disorders such as anxiety and depression, dose related and longer term effects of antiepileptic drugs, including on prenatal development and bone health, and neurobehavioural effects. ...
These include mood disorders such as anxiety and depression, dose related and longer term effects of antiepileptic drugs, including o …
A feasibility study of a brief psycho-educational intervention for psychogenic nonepileptic seizures.
Mayor R, Brown RJ, Cock H, House A, Howlett S, Smith P, Reuber M. Mayor R, et al. Among authors: cock h. Seizure. 2013 Nov;22(9):760-5. doi: 10.1016/j.seizure.2013.06.008. Epub 2013 Aug 2. Seizure. 2013. PMID: 23916276 Free article.
The intervention was associated with higher rates of PNES cessation than those observed in our previous studies describing the short-term outcome of the communication of the diagnosis alone. An RCT of the intervention is justified but a significant proportion of drop-outs …
The intervention was associated with higher rates of PNES cessation than those observed in our previous studies describing the short-term …
Short-term outcome of psychogenic non-epileptic seizures after communication of the diagnosis.
Mayor R, Brown RJ, Cock H, House A, Howlett S, Singhal S, Smith P, Reuber M. Mayor R, et al. Among authors: cock h. Epilepsy Behav. 2012 Dec;25(4):676-81. doi: 10.1016/j.yebeh.2012.09.033. Epub 2012 Nov 15. Epilepsy Behav. 2012. PMID: 23168089
We previously described a communication strategy for the delivery of the diagnosis of psychogenic non-epileptic seizures (PNES) that was acceptable and effective at communicating the psychological cause of PNES. This prospective multicenter study describes the short-term s …
We previously described a communication strategy for the delivery of the diagnosis of psychogenic non-epileptic seizures (PNES) that was acc …
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