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Sex- and strain-specific effects of mitochondrial uncoupling on age-related metabolic diseases in high-fat diet-fed mice.
Goedeke L, Murt KN, Di Francesco A, Camporez JP, Nasiri AR, Wang Y, Zhang XM, Cline GW, de Cabo R, Shulman GI. Goedeke L, et al. Among authors: cline gw. Aging Cell. 2022 Feb;21(2):e13539. doi: 10.1111/acel.13539. Epub 2022 Jan 28. Aging Cell. 2022. PMID: 35088525 Free PMC article.
CRMP treatment was also associated with a significant reduction in hepatic lipid peroxidation, protein carbonylation, and inflammation. Importantly, long-term (49 weeks) hepatic mitochondrial uncoupling initiated late in life (94-104 weeks), in conjugation with HFD feeding …
CRMP treatment was also associated with a significant reduction in hepatic lipid peroxidation, protein carbonylation, and inflammation. Impo …
Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates.
Goedeke L, Peng L, Montalvo-Romeral V, Butrico GM, Dufour S, Zhang XM, Perry RJ, Cline GW, Kievit P, Chng K, Petersen KF, Shulman GI. Goedeke L, et al. Among authors: cline gw. Sci Transl Med. 2019 Oct 2;11(512):eaay0284. doi: 10.1126/scitranslmed.aay0284. Sci Transl Med. 2019. PMID: 31578240 Free PMC article.
Although we previously demonstrated that CRMP safely reverses hypertriglyceridemia, fatty liver, hepatic inflammation, and fibrosis in diet-induced rodent models of obesity, there remains a critical need to assess its safety and efficacy in a model highly relevant to humans. Here …
Although we previously demonstrated that CRMP safely reverses hypertriglyceridemia, fatty liver, hepatic inflammation, and fibrosis in diet- …
Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.
Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI. Goedeke L, et al. Among authors: cline gw. Hepatology. 2018 Dec;68(6):2197-2211. doi: 10.1002/hep.30097. Hepatology. 2018. PMID: 29790582 Free PMC article.
Furthermore, administration for 6 days to high-fructose-fed rats resulted in a 20% reduction in hepatic de novo lipogenesis. Importantly, long-term treatment (21 days) significantly reduced high-fat sucrose diet-induced hepatic steatosis, protein kinase C epsilon activatio …
Furthermore, administration for 6 days to high-fructose-fed rats resulted in a 20% reduction in hepatic de novo lipogenesis. Importantly, lo …
NMR spectroscopy in beta cell engineering and islet transplantation.
Papas KK, Colton CK, Gounarides JS, Roos ES, Jarema MA, Shapiro MJ, Cheng LL, Cline GW, Shulman GI, Wu H, Bonner-Weir S, Weir GC. Papas KK, et al. Among authors: cline gw. Ann N Y Acad Sci. 2001 Nov;944:96-119. doi: 10.1111/j.1749-6632.2001.tb03826.x. Ann N Y Acad Sci. 2001. PMID: 11797699
Islet transplantation is a promising method for restoring normoglycemia and alleviating the long term complications of diabetes. Widespread application of islet transplantation is hindered by the limited supply of human islets and requires a large increase in the availabil …
Islet transplantation is a promising method for restoring normoglycemia and alleviating the long term complications of diabetes. Wide …