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Identification of three mechanistic pathways for iron-deficient heart failure.
Packer M, Anker SD, Butler J, Cleland JGF, Kalra PR, Mentz RJ, Ponikowski P. Packer M, et al. Among authors: cleland jgf. Eur Heart J. 2024 May 11:ehae284. doi: 10.1093/eurheartj/ehae284. Online ahead of print. Eur Heart J. 2024. PMID: 38733250

Marked hypoferraemia (typically with anaemia) can drive the depletion of cardiomyocyte iron, impairing contractile performance and explaining why a transferrin saturation < 15%-16% predicts the ability of intravenous iron to reduce the risk of major heart failure events in lon

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Marked hypoferraemia (typically with anaemia) can drive the depletion of cardiomyocyte iron, impairing contractile performance and explainin …
Outcomes of Cardiac Resynchronization Therapy by New York Heart Association Class: A Patient-Level Meta-Analysis.
Shivakumar N, Friedman DJ, Fudim M, Abraham WT, Cleland JGF, Curtis AB, Gold MR, Kutyifa V, Linde C, Young J, Tang A, Olivas-Martinez A, Inoue LYT, Sanders GD, Al-Khatib SM. Shivakumar N, et al. Among authors: cleland jgf. medRxiv [Preprint]. 2023 Jul 6:2023.07.05.23292279. doi: 10.1101/2023.07.05.23292279. medRxiv. 2023. PMID: 37461448 Free PMC article. Preprint.
We assessed if this association differs between NYHA III and IV groups by adding an interaction term between CRT and NYHA class as a random effect. A sensitivity analysis was performed by including data from the RAFT trial. ...
We assessed if this association differs between NYHA III and IV groups by adding an interaction term between CRT and NYHA class as a …
A machine learning-derived echocardiographic algorithm identifies people at risk of heart failure with distinct cardiac structure, function, and response to spironolactone: Findings from the HOMAGE trial.
Kobayashi M, Huttin O, Ferreira JP, Duarte K, González A, Heymans S, Verdonschot JAJ, Brunner-La Rocca HP, Pellicori P, Clark AL, Petutschnigg J, Edelmann F, Cleland JG, Rossignol P, Zannad F, Girerd N; HOMAGE Trial Committees and Investigators. Kobayashi M, et al. Among authors: cleland jg. Eur J Heart Fail. 2023 Aug;25(8):1284-1289. doi: 10.1002/ejhf.2859. Epub 2023 Apr 26. Eur J Heart Fail. 2023. PMID: 37062878
AIM: An echocardiographic algorithm derived by machine learning (e'VM) characterizes pre-clinical individuals with different cardiac structure and function, biomarkers, and long-term risk of heart failure (HF). Our aim was the external validation of the e'VM algorithm and …
AIM: An echocardiographic algorithm derived by machine learning (e'VM) characterizes pre-clinical individuals with different cardiac structu …
Impact of left ventricular ejection fraction phenotypes on healthcare resource utilization in hospitalized heart failure: a secondary analysis of REPORT-HF.
Farmakis D, Tromp J, Marinaki S, Ouwerkerk W, Angermann CE, Bistola V, Dahlstrom U, Dickstein K, Ertl G, Ghadanfar M, Hassanein M, Obergfell A, Perrone SV, Polyzogopoulou E, Schweizer A, Boletis I, Cleland JGF, Collins SP, Lam CSP, Filippatos G. Farmakis D, et al. Among authors: cleland jgf. Eur J Heart Fail. 2023 Jun;25(6):818-828. doi: 10.1002/ejhf.2833. Epub 2023 Apr 12. Eur J Heart Fail. 2023. PMID: 36974770
Discharge prescription of neurohormonal inhibitors was suboptimal in HFrEF and lower but significant in patients with HFpEF and HFmrEF, who had better long-term cardiovascular outcomes than HFrEF, but similar risk for non-cardiovascular events....
Discharge prescription of neurohormonal inhibitors was suboptimal in HFrEF and lower but significant in patients with HFpEF and HFmrEF, who …
Diuretic dose trajectories in dilated cardiomyopathy: prognostic implications.
Nuzzi V, Cannatà A, Pellicori P, Manca P, Stolfo D, Gregorio C, Barbati G, Bromage DI, McDonagh T, Cleland JGF, Merlo M, Sinagra G. Nuzzi V, et al. Among authors: cleland jgf. Clin Res Cardiol. 2023 Mar;112(3):419-430. doi: 10.1007/s00392-022-02126-8. Epub 2022 Nov 17. Clin Res Cardiol. 2023. PMID: 36385396 Free PMC article.
Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial.
Kalra PR, Cleland JGF, Petrie MC, Thomson EA, Kalra PA, Squire IB, Ahmed FZ, Al-Mohammad A, Cowburn PJ, Foley PWX, Graham FJ, Japp AG, Lane RE, Lang NN, Ludman AJ, Macdougall IC, Pellicori P, Ray R, Robertson M, Seed A, Ford I; IRONMAN Study Group. Kalra PR, et al. Among authors: cleland jgf. Lancet. 2022 Dec 17;400(10369):2199-2209. doi: 10.1016/S0140-6736(22)02083-9. Epub 2022 Nov 5. Lancet. 2022. PMID: 36347265 Free article. Clinical Trial.
BACKGROUND: For patients with heart failure, reduced left ventricular ejection fraction and iron deficiency, intravenous ferric carboxymaltose administration improves quality of life and exercise capacity in the short-term and reduces hospital admissions for heart failure …
BACKGROUND: For patients with heart failure, reduced left ventricular ejection fraction and iron deficiency, intravenous ferric carboxymalto …
Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease.
Bhandari S, Mehta S, Khwaja A, Cleland JGF, Ives N, Brettell E, Chadburn M, Cockwell P; STOP ACEi Trial Investigators. Bhandari S, et al. Among authors: cleland jgf. N Engl J Med. 2022 Dec 1;387(22):2021-2032. doi: 10.1056/NEJMoa2210639. Epub 2022 Nov 3. N Engl J Med. 2022. PMID: 36326117 Free article. Clinical Trial.
CONCLUSIONS: Among patients with advanced and progressive chronic kidney disease, the discontinuation of RAS inhibitors was not associated with a significant between-group difference in the long-term rate of decrease in the eGFR. (Funded by the National Institute for Healt …
CONCLUSIONS: Among patients with advanced and progressive chronic kidney disease, the discontinuation of RAS inhibitors was not associated w …
Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise-CISCO-21.
Morrow A, Gray SR, Bayes HK, Sykes R, McGarry E, Anderson D, Boiskin D, Burke C, Cleland JGF, Goodyear C, Ibbotson T, Lang CC, McConnachie, Mair F, Mangion K, Patel M, Sattar N, Taggart D, Taylor R, Dawkes S, Berry C. Morrow A, et al. Among authors: cleland jgf. Trials. 2022 Aug 15;23(1):660. doi: 10.1186/s13063-022-06632-y. Trials. 2022. PMID: 35971155 Free PMC article. Clinical Trial.
Rationale and design of a randomised trial of intravenous iron in patients with heart failure.
Kalra PR, Cleland JG, Petrie MC, Ahmed FZ, Foley PW, Kalra PA, Lang NN, Lane RE, Macdougall IC, Pellicori P, Pope MTB, Robertson M, Squire IB, Thomson EA, Ford I. Kalra PR, et al. Among authors: cleland jg. Heart. 2022 Nov 24;108(24):1979-1985. doi: 10.1136/heartjnl-2022-321304. Heart. 2022. PMID: 35948408 Free PMC article. Clinical Trial.
The Effectiveness of Intravenous iron treatment versus standard care in patients with heart failure and iron deficiency (IRONMAN) trial evaluated whether the benefits of intravenous iron persist in the longer term and impact on morbidity and mortality. METHODS: IRONMAN is …
The Effectiveness of Intravenous iron treatment versus standard care in patients with heart failure and iron deficiency (IRONMAN) trial eval …
Maintaining Success for Patients With Dilated Cardiomyopathy and Remission of Heart Failure.
Halliday BP, Cleland JGF. Halliday BP, et al. Among authors: cleland jgf. JACC Basic Transl Sci. 2022 May 23;7(5):500-503. doi: 10.1016/j.jacbts.2022.03.008. eCollection 2022 May. JACC Basic Transl Sci. 2022. PMID: 35663636 Free PMC article.
Once remission has been achieved, it is unclear which treatments need to be continued long term. The durability of remission and likelihood of relapse are likely to be determined by intrinsic myocardial susceptibility, the persistence or recurrence of any acquired triggers …
Once remission has been achieved, it is unclear which treatments need to be continued long term. The durability of remission and like …
121 results