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A novel method for the establishment of autologous skin cell suspensions: characterisation of cellular sub-populations, epidermal stem cell content and wound response-enhancing biological properties.
Peake M, Dunnill C, Ibraheem K, Smith A, Clarke DJ, Georgopoulos NT. Peake M, et al. Among authors: clarke dj. Front Bioeng Biotechnol. 2024 Apr 5;12:1386896. doi: 10.3389/fbioe.2024.1386896. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 38646012 Free PMC article.
Results: Our methodology permitted efficient recovery of keratinocytes, fibroblasts and melanocytes, which remained viable upon long-term culture. ACS-derivatives comprised sub-populations with the CD49-high/CD71-low expression profile known to demarcate EpSCs. ...
Results: Our methodology permitted efficient recovery of keratinocytes, fibroblasts and melanocytes, which remained viable upon long-term …
Demonstration of stable, long-term operation of a nanosecond pulsed DPSSL at 10 J, 100 Hz.
De Vido M, Quinn G, Clarke D, McHugh L, Mason P, Spear J, Smith JM, Divoky M, Pilar J, Denk O, Butcher TJ, Edwards C, Mocek T, Collier JL. De Vido M, et al. Among authors: clarke d. Opt Express. 2024 Mar 25;32(7):11907-11915. doi: 10.1364/OE.521049. Opt Express. 2024. PMID: 38571028 Free article.
We report on stable, long-term operation of a diode-pumped solid-state laser (DPSSL) amplifying 15 ns pulses at 1029.5 nm wavelength to 10 J energy at 100 Hz pulse rate, corresponding to 1 kW average power, with 25.4% optical-to-optical efficiency. ...The laser was also op …
We report on stable, long-term operation of a diode-pumped solid-state laser (DPSSL) amplifying 15 ns pulses at 1029.5 nm wavelength …
Inflammatory Cytokine Elaboration Following Secondhand Smoke (SHS) Exposure Is Mediated in Part by RAGE Signaling.
Curtis KL, Homer KM, Wendt RA, Stapley BM, Clark ET, Harward K, Chang A, Clarke DM, Arroyo JA, Reynolds PR. Curtis KL, et al. Among authors: clarke dm. Int J Mol Sci. 2023 Oct 27;24(21):15645. doi: 10.3390/ijms242115645. Int J Mol Sci. 2023. PMID: 37958629 Free PMC article.
However, the chronic inflammatory mechanisms associated with RAGE have yet to be fully elucidated. In this study, we address the impact of long-term SHS exposure on RAGE signaling. RAGE knockout (RKO) and wild-type (WT) mice were exposed to SHS using a nose-only delivery s …
However, the chronic inflammatory mechanisms associated with RAGE have yet to be fully elucidated. In this study, we address the impact of l …
An intervention to support stroke survivors and their carers in the longer term: results of a cluster randomised controlled feasibility trial (LoTS2Care).
Forster A, Ozer S, Brindle R, Barnard L, Hardicre N, Crocker TF, Chenery M, Moreau L, Wright A, Burton LJ, Hartley S, Hulme C, Dawkins B, Holloway I, House A, Hewison J, Farrin A; LoTS2Care Programme Team. Forster A, et al. Pilot Feasibility Stud. 2023 Mar 15;9(1):40. doi: 10.1186/s40814-023-01258-6. Pilot Feasibility Stud. 2023. PMID: 36922866 Free PMC article.
BACKGROUND: To address the limited provision of longer-term stroke care, we conducted a programme of research (LoTS2Care) to develop and test an intervention to form part of a replicable longer-term care strategy. ...There were no safety concerns. CONCLUSIONS: Strok …
BACKGROUND: To address the limited provision of longer-term stroke care, we conducted a programme of research (LoTS2Care) to develop …
Microglial morphology in the somatosensory cortex across lifespan. A quantitative study.
Godeanu S, Clarke D, Stopper L, Deftu AF, Popa-Wagner A, Bălșeanu AT, Scheller A, Catalin B. Godeanu S, et al. Among authors: clarke d. Dev Dyn. 2023 Aug;252(8):1113-1129. doi: 10.1002/dvdy.582. Epub 2023 Mar 16. Dev Dyn. 2023. PMID: 36883224
To accomplish this task, they constantly change their morphology both in the short and long term under physiological conditions. This makes the process of quantifying physiological microglial morphology difficult. ...
To accomplish this task, they constantly change their morphology both in the short and long term under physiological conditions. This …
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Chien HT, Prior H, Andrews L, van Aerts L, Cauvin A, Clarke DO, Datta K, Dempster M, Dybdal N, Freebern W, de Haan L, Herzyk D, Hey A, Kissner T, Kronenberg S, Leach MW, Lee D, Schutte K, Sewell F, Trouba K, Ulrich P, Weir L, van Meer P. Chien HT, et al. Among authors: clarke do. Regul Toxicol Pharmacol. 2023 Feb;138:105329. doi: 10.1016/j.yrtph.2022.105329. Epub 2022 Dec 30. Regul Toxicol Pharmacol. 2023. PMID: 36592682 Free article.
We evaluated whether a 6-month toxicity study is necessary to assess the long-term safety of mAbs. Data on First-in-Human (FIH)-enabling and chronic toxicity studies were shared for 142 mAbs submitted by 11 companies. ...
We evaluated whether a 6-month toxicity study is necessary to assess the long-term safety of mAbs. Data on First-in-Human (FIH)-enabl …
Brain transplantation of genetically corrected Sanfilippo type B neural stem cells induces partial cross-correction of the disease.
Pearse Y, Clarke D, Kan SH, Le SQ, Sanghez V, Luzzi A, Pham I, Nih LR, Cooper JD, Dickson PI, Iacovino M. Pearse Y, et al. Among authors: clarke d. Mol Ther Methods Clin Dev. 2022 Oct 27;27:452-463. doi: 10.1016/j.omtm.2022.10.013. eCollection 2022 Dec 8. Mol Ther Methods Clin Dev. 2022. PMID: 36419468 Free PMC article.
After brain transplantation of corrected iNSCs into Naglu (-/-) mice and long-term evaluation of their impact, we successfully detected NAGLU-IGFII activity in all transplanted animals. ...
After brain transplantation of corrected iNSCs into Naglu (-/-) mice and long-term evaluation of their impact, we successfully detect …
Intermediaries in the justice system for people with communication disability: Enacting Sustainable Development Goal 16 in Ireland, Northern Ireland, and New Zealand.
Kearns Á, Clarke D, Cusack A, Gallagher A, Humphreys J, Kedge S, McKee A. Kearns Á, et al. Among authors: clarke d. Int J Speech Lang Pathol. 2023 Feb;25(1):141-146. doi: 10.1080/17549507.2022.2134457. Epub 2022 Nov 8. Int J Speech Lang Pathol. 2023. PMID: 36345978
As various terms are used to describe the intermediary role including communication assistants and registered intermediaries, the term intermediary will be used throughout. CONCLUSION: Although the scope of the role of intermediaries varies across settings in line with pol …
As various terms are used to describe the intermediary role including communication assistants and registered intermediaries, the term …
What babies need: accelerating access to current and novel antiretroviral drugs in neonates through pharmacokinetic studies.
Jacobs TG, Schouwenburg S, Penazzato M, Archary M, Ruel TD, van den Anker J, Burger DM, Cressey TR, Abrams EJ, Lyall H, Bekker A, Colbers A; Penta Clinical Pharmacology Working Group; PADO-HIV 5 participants. Jacobs TG, et al. Lancet HIV. 2022 Sep;9(9):e649-e657. doi: 10.1016/S2352-3018(22)00121-7. Epub 2022 Jul 18. Lancet HIV. 2022. PMID: 35863363 Review.
Although 23 antiretroviral drugs are approved for use in adults, only six are approved by regulatory authorities for use in term neonates born to women with HIV, with even fewer options for preterm neonates. ...
Although 23 antiretroviral drugs are approved for use in adults, only six are approved by regulatory authorities for use in term neon …
SigCom LINCS: data and metadata search engine for a million gene expression signatures.
Evangelista JE, Clarke DJB, Xie Z, Lachmann A, Jeon M, Chen K, Jagodnik KM, Jenkins SL, Kuleshov MV, Wojciechowicz ML, Schürer SC, Medvedovic M, Ma'ayan A. Evangelista JE, et al. Among authors: clarke djb. Nucleic Acids Res. 2022 Jul 5;50(W1):W697-W709. doi: 10.1093/nar/gkac328. Nucleic Acids Res. 2022. PMID: 35524556 Free PMC article.
SigCom LINCS provides a rapid signature similarity search for mimickers and reversers given sets of up and down genes, a gene set, a single gene, or any search term. Additionally, users of SigCom LINCS can perform a metadata search to find and analyze subsets of signatures …
SigCom LINCS provides a rapid signature similarity search for mimickers and reversers given sets of up and down genes, a gene set, a single …
147 results