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Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation.
Rexach JE, Clark PM, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC. Rexach JE, et al. Among authors: clark pm. Nat Chem Biol. 2012 Jan 22;8(3):253-61. doi: 10.1038/nchembio.770. Nat Chem Biol. 2012. PMID: 22267118 Free PMC article.
The transcription factor cyclic AMP-response element binding protein (CREB) is a key regulator of many neuronal processes, including brain development, circadian rhythm and long-term memory. Studies of CREB have focused on its phosphorylation, although the diversity of CRE …
The transcription factor cyclic AMP-response element binding protein (CREB) is a key regulator of many neuronal processes, including brain d …
Prechemotherapy alterations in brain function in women with breast cancer.
Cimprich B, Reuter-Lorenz P, Nelson J, Clark PM, Therrien B, Normolle D, Berman MG, Hayes DF, Noll DC, Peltier S, Welsh RC. Cimprich B, et al. Among authors: clark pm. J Clin Exp Neuropsychol. 2010 Mar;32(3):324-31. doi: 10.1080/13803390903032537. Epub 2009 Jul 29. J Clin Exp Neuropsychol. 2010. PMID: 19642048
Determinants of cognitive ability at 7 years: a longitudinal case-control study of children born small-for-gestational age at term.
Theodore RF, Thompson JM, Waldie KE, Becroft DM, Robinson E, Wild CJ, Clark PM, Mitchell EA. Theodore RF, et al. Among authors: clark pm. Eur J Pediatr. 2009 Oct;168(10):1217-24. doi: 10.1007/s00431-008-0913-9. Epub 2009 Jan 23. Eur J Pediatr. 2009. PMID: 19165501
The aim of this study was to identify the determinants of children's intelligence at 7 years, including pregnancy, postnatal, demographic factors, and small-for-gestational age (SGA) birth at term. Information was collected at birth (n = 871), 1 year (n = 744 …
The aim of this study was to identify the determinants of children's intelligence at 7 years, including pregnancy, postnatal, demographic fa …
Mutations in the glucokinase gene of the fetus result in reduced placental weight.
Shields BM, Spyer G, Slingerland AS, Knight BA, Ellard S, Clark PM, Hauguel-de Mouzon S, Hattersley AT. Shields BM, et al. Among authors: clark pm. Diabetes Care. 2008 Apr;31(4):753-7. doi: 10.2337/dc07-1750. Epub 2008 Jan 9. Diabetes Care. 2008. PMID: 18184897
Birth weight, placental weight, umbilical cord insulin, and maternal glucose and insulin concentrations were measured in 573 nondiabetic, healthy, term pregnancies. ...In the normal pregnancies, placental weight was strongly correlated with birth weight (r = …
Birth weight, placental weight, umbilical cord insulin, and maternal glucose and insulin concentrations were measured in 573 nondiabe …
Nonprescription medication purchases and the role of pharmacists as healthcare workers in self-medication in Istanbul.
Gül H, Omurtag G, Clark PM, Tozan A, Ozel S. Gül H, et al. Among authors: clark pm. Med Sci Monit. 2007 Jul;13(7):PH9-14. Med Sci Monit. 2007. PMID: 17599034
BACKGROUND: In Turkey, some drugs can be purchased from pharmacists without a prescription and there is no legal classification corresponding to the international term "over-the-counter drugs". The purpose of this study was to identify these non-prescribed drugs and to def …
BACKGROUND: In Turkey, some drugs can be purchased from pharmacists without a prescription and there is no legal classification correspondin …
Determinants of developmental delay in infants aged 12 months.
Slykerman RF, Thompson JM, Clark PM, Becroft DM, Robinson E, Pryor JE, Wild CJ, Mitchell EA. Slykerman RF, et al. Among authors: clark pm. Paediatr Perinat Epidemiol. 2007 Mar;21(2):121-8. doi: 10.1111/j.1365-3016.2007.00796.x. Paediatr Perinat Epidemiol. 2007. PMID: 17302641
The aim of this study was to determine which demographic, maternal, obstetric and postnatal variables were associated with achievement of developmental milestones at the age of 12 months in term infants. Mothers and babies were enrolled in the Auckland Birthweight Collabor …
The aim of this study was to determine which demographic, maternal, obstetric and postnatal variables were associated with achievement of de …
The long-term impact on offspring of exposure to hyperglycaemia in utero due to maternal glucokinase gene mutations.
Singh R, Pearson ER, Clark PM, Hattersley AT. Singh R, et al. Among authors: clark pm. Diabetologia. 2007 Mar;50(3):620-4. doi: 10.1007/s00125-006-0541-8. Epub 2007 Jan 10. Diabetologia. 2007. PMID: 17216282
Offspring born to mothers with a mutation in the glucokinase gene (GCK) are a good model for studying exposure to moderate hyperglycaemia, as mutation carriers have fasting hyperglycaemia throughout life including during pregnancy. We assessed the long term effects of expo …
Offspring born to mothers with a mutation in the glucokinase gene (GCK) are a good model for studying exposure to moderate hyperglycaemia, a …
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Søvik O, Polak M, Hattersley AT; Neonatal Diabetes International Collaborative Group. Pearson ER, et al. Among authors: clark pm. N Engl J Med. 2006 Aug 3;355(5):467-77. doi: 10.1056/NEJMoa061759. N Engl J Med. 2006. PMID: 16885550 Free article.
Exogenous glucagon increased insulin secretion only in the presence of sulfonylureas. CONCLUSIONS: Sulfonylurea therapy is safe in the short term for patients with diabetes caused by KCNJ11 mutations and is probably more effective than insulin therapy. ...
Exogenous glucagon increased insulin secretion only in the presence of sulfonylureas. CONCLUSIONS: Sulfonylurea therapy is safe in the short …
Paternal insulin resistance and its association with umbilical cord insulin concentrations.
Shields BM, Knight B, Turner M, Wilkins-Wall B, Shakespeare L, Powell RJ, Hannemann M, Clark PM, Yajnik CS, Hattersley AT. Shields BM, et al. Among authors: clark pm. Diabetologia. 2006 Nov;49(11):2668-74. doi: 10.1007/s00125-006-0282-8. Epub 2006 May 16. Diabetologia. 2006. PMID: 16703330
SUBJECTS, MATERIALS AND METHODS: To assess this, we analysed plasma insulin concentration in umbilical cord blood from 644 normal, term, UK Caucasian deliveries from the Exeter Family Study of Childhood Health. ...RESULTS: As expected, cord insulin concentrations correlate …
SUBJECTS, MATERIALS AND METHODS: To assess this, we analysed plasma insulin concentration in umbilical cord blood from 644 normal, term …
The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis.
Agha A, Tomlinson JW, Clark PM, Holder G, Stewart PM. Agha A, et al. Among authors: clark pm. J Clin Endocrinol Metab. 2006 Jan;91(1):43-7. doi: 10.1210/jc.2005-1131. Epub 2005 Oct 25. J Clin Endocrinol Metab. 2006. PMID: 16249286
CONTEXT: The high-dose short Synacthen (corticotropin) test (SST) is widely used to investigate suspected secondary adrenal insufficiency, but concern remains about falsely reassuring results. OBJECTIVE: Our objective was to evaluate the long-term safety of the SST. METHOD …
CONTEXT: The high-dose short Synacthen (corticotropin) test (SST) is widely used to investigate suspected secondary adrenal insufficiency, b …
24 results