Chronic matrix metalloproteinase inhibition following myocardial infarction in mice: differential effects on short and long-term survival.
Spinale FG, Escobar GP, Hendrick JW, Clark LL, Camens SS, Mingoia JP, Squires CG, Stroud RE, Ikonomidis JS.
Spinale FG, et al. Among authors: clark ll.
J Pharmacol Exp Ther. 2006 Sep;318(3):966-73. doi: 10.1124/jpet.106.104455. Epub 2006 Jun 6.
J Pharmacol Exp Ther. 2006.
PMID: 16757539
Left ventricular (LV) remodeling occurs after myocardial infarction (MI), and the matrix metalloproteinases (MMPs) contribute to adverse LV remodeling after MI. Short-term pharmacological MMP inhibition (MMPi; days to weeks) in animal models of MI have demonstrated a reduc …
Left ventricular (LV) remodeling occurs after myocardial infarction (MI), and the matrix metalloproteinases (MMPs) contribute to adverse LV …