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Gadolinium Deposition: A Study Review.
Strickler SE, Clark KR. Strickler SE, et al. Among authors: clark kr. Radiol Technol. 2021 Jan;92(3):249-258. Radiol Technol. 2021. PMID: 33472877
The clinical significance of retained gadolinium in the brain is unknown. Long-term studies are necessary to determine whether gadolinium deposition in the brain causes neurological deficits. ...
The clinical significance of retained gadolinium in the brain is unknown. Long-term studies are necessary to determine whether gadoli …
AAV1.NT-3 gene therapy for charcot-marie-tooth neuropathy.
Sahenk Z, Galloway G, Clark KR, Malik V, Rodino-Klapac LR, Kaspar BK, Chen L, Braganza C, Montgomery C, Mendell JR. Sahenk Z, et al. Among authors: clark kr. Mol Ther. 2014 Mar;22(3):511-521. doi: 10.1038/mt.2013.250. Epub 2013 Oct 28. Mol Ther. 2014. PMID: 24162799 Free PMC article.
In previous studies, we showed that neurotrophin-3 (NT-3) improved the trembler(J) (Tr(J)) mouse and also showed efficacy in CMT1A patients. Long-term treatment with NT-3 was not possible related to its short half-life and lack of availability. ...
In previous studies, we showed that neurotrophin-3 (NT-3) improved the trembler(J) (Tr(J)) mouse and also showed efficacy in CMT1A patients. …
Evaluation of the fate of rAAV genomes following in vivo administration.
Clark KR, Penaud-Budloo M. Clark KR, et al. Methods Mol Biol. 2011;807:239-58. doi: 10.1007/978-1-61779-370-7_10. Methods Mol Biol. 2011. PMID: 22034033
Recombinant adeno-associated virus (rAAV) vectors are capable of mediating long-term gene expression in a wide variety of animals, including primates. ...
Recombinant adeno-associated virus (rAAV) vectors are capable of mediating long-term gene expression in a wide variety of animals, in …
Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D.
Mendell JR, Rodino-Klapac LR, Rosales XQ, Coley BD, Galloway G, Lewis S, Malik V, Shilling C, Byrne BJ, Conlon T, Campbell KJ, Bremer WG, Taylor LE, Flanigan KM, Gastier-Foster JM, Astbury C, Kota J, Sahenk Z, Walker CM, Clark KR. Mendell JR, et al. Among authors: clark kr. Ann Neurol. 2010 Nov;68(5):629-38. doi: 10.1002/ana.22251. Ann Neurol. 2010. PMID: 21031578 Free PMC article. Clinical Trial.
INTERPRETATION: The findings of this gene replacement study in LGMD2D subjects have important implications not previously demonstrated in muscular dystrophy. Long-term, sustainable gene expression of alpha-sarcoglycan was observed following gene transfer mediated by AAV. . …
INTERPRETATION: The findings of this gene replacement study in LGMD2D subjects have important implications not previously demonstrated in mu …
Follistatin gene delivery enhances muscle growth and strength in nonhuman primates.
Kota J, Handy CR, Haidet AM, Montgomery CL, Eagle A, Rodino-Klapac LR, Tucker D, Shilling CJ, Therlfall WR, Walker CM, Weisbrode SE, Janssen PM, Clark KR, Sahenk Z, Mendell JR, Kaspar BK. Kota J, et al. Among authors: clark kr. Sci Transl Med. 2009 Nov 11;1(6):6ra15. doi: 10.1126/scitranslmed.3000112. Sci Transl Med. 2009. PMID: 20368179 Free PMC article.
When injected into the quadriceps of cynomolgus macaque monkeys, a follistatin isoform expressed from an adeno-associated virus serotype 1 vector, AAV1-FS344, induced pronounced and durable increases in muscle size and strength. Long-term expression of the transgene did no …
When injected into the quadriceps of cynomolgus macaque monkeys, a follistatin isoform expressed from an adeno-associated virus serotype 1 v …
Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection.
van den Pol AN, Acuna-Goycolea C, Clark KR, Ghosh PK. van den Pol AN, et al. Among authors: clark kr. Neuron. 2004 May 27;42(4):635-52. doi: 10.1016/s0896-6273(04)00251-x. Neuron. 2004. PMID: 15157424 Free article.
We have developed a viral approach with AAV for selective long-term reporter gene (GFP) expression in MCH neurons, allowing the study of their cellular physiology in hypothalamic slices. ...
We have developed a viral approach with AAV for selective long-term reporter gene (GFP) expression in MCH neurons, allowing the study …
Genetic fate of recombinant adeno-associated virus vector genomes in muscle.
Schnepp BC, Clark KR, Klemanski DL, Pacak CA, Johnson PR. Schnepp BC, et al. Among authors: clark kr. J Virol. 2003 Mar;77(6):3495-504. doi: 10.1128/jvi.77.6.3495-3504.2003. J Virol. 2003. PMID: 12610125 Free PMC article.
Recombinant adeno-associated virus (rAAV) vectors are promising human gene transfer vectors, because they mediate long-term gene expression in vivo. The vector DNA form responsible for sustained gene expression has not been clearly defined, but it has been presumed that th …
Recombinant adeno-associated virus (rAAV) vectors are promising human gene transfer vectors, because they mediate long-term gene expr …
Gene transfer into the CNS using recombinant adeno-associated virus: analysis of vector DNA forms resulting in sustained expression.
Clark KR, Sferra TJ, Lo W, Qu G, Chen R, Johnson PR. Clark KR, et al. J Drug Target. 1999 Dec;7(4):269-83. doi: 10.3109/10611869909085510. J Drug Target. 1999. PMID: 10682906
These data are the first to document the existence of multiple vector DNA forms present within the adult murine brain following direct rAAV inoculation and therefore, provide insight into the molecular events that ultimately result in long-term rAAV mediated transgene expr …
These data are the first to document the existence of multiple vector DNA forms present within the adult murine brain following direct rAAV …