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1963 1
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2009 2
2011 2
2012 4
2014 2
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2018 1
2019 1
2021 3
2022 1
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24 results

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Page 1
Cystic Fibrosis and Its Management Through Established and Emerging Therapies.
Spielberg DR, Clancy JP. Spielberg DR, et al. Among authors: clancy jp. Annu Rev Genomics Hum Genet. 2016 Aug 31;17:155-75. doi: 10.1146/annurev-genom-090314-050024. Epub 2016 Feb 22. Annu Rev Genomics Hum Genet. 2016. PMID: 26905785 Review.
CF treatments continue to advance with greater understanding of factors influencing long-term morbidity and mortality. In recent years, in-depth understanding of genetic and protein structure-function relationships has led to the introduction of targeted therapies for pati …
CF treatments continue to advance with greater understanding of factors influencing long-term morbidity and mortality. In recent year …
CFTR modulator theratyping: Current status, gaps and future directions.
Clancy JP, Cotton CU, Donaldson SH, Solomon GM, VanDevanter DR, Boyle MP, Gentzsch M, Nick JA, Illek B, Wallenburg JC, Sorscher EJ, Amaral MD, Beekman JM, Naren AP, Bridges RJ, Thomas PJ, Cutting G, Rowe S, Durmowicz AG, Mense M, Boeck KD, Skach W, Penland C, Joseloff E, Bihler H, Mahoney J, Borowitz D, Tuggle KL. Clancy JP, et al. J Cyst Fibros. 2019 Jan;18(1):22-34. doi: 10.1016/j.jcf.2018.05.004. Epub 2018 Jun 20. J Cyst Fibros. 2019. PMID: 29934203 Free PMC article. Review.
The theme of the workshop was centered on CFTR theratyping, a term that encompasses the use of CFTR modulators to define defects in CFTR in vitro, with application to both common and rare CFTR variants. ...
The theme of the workshop was centered on CFTR theratyping, a term that encompasses the use of CFTR modulators to define defects in C …
PROMISE: Working with the CF community to understand emerging clinical and research needs for those treated with highly effective CFTR modulator therapy.
Nichols DP, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Sagel SD, Rosenfeld M, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Kirby S, VanDalfsen JM, Clancy JP, Rowe SM. Nichols DP, et al. Among authors: clancy jp. J Cyst Fibros. 2021 Mar;20(2):205-212. doi: 10.1016/j.jcf.2021.02.003. Epub 2021 Feb 19. J Cyst Fibros. 2021. PMID: 33619012 Free PMC article. Review.
Multiple observational research studies are now being conducted to better understand the impacts of this important therapeutic milestone on long-term outcomes, patient care needs, and future research priorities. ...
Multiple observational research studies are now being conducted to better understand the impacts of this important therapeutic milestone on …
Intermediate and long-term regulation of acid-base homeostasis.
Clancy J, McVicar A. Clancy J, et al. Br J Nurs. 2007 Sep 27-Oct 10;16(17):1076-9. doi: 10.12968/bjon.2007.16.17.27253. Br J Nurs. 2007. PMID: 18026053 Review.
The first part of this two-part article (Clancy and McVicar, 2007) identified acid and alkaline buffers in the body fluids as the body's short-term homeostatic mechanisms involved in maintaining the 'acid-base homeostasis' of body fluids. The second part of this article ex …
The first part of this two-part article (Clancy and McVicar, 2007) identified acid and alkaline buffers in the body fluids as the body's sho …
Short-term regulation of acid-base homeostasis of body fluids.
Clancy J, McVicar A. Clancy J, et al. Br J Nurs. 2007 Sep 13-27;16(16):1016-21. doi: 10.12968/bjon.2007.16.16.27082. Br J Nurs. 2007. PMID: 18026041 Review.
The first in this two-part article explores the short-term homeostatic mechanisms involved in maintaining the 'acid-base balance' of body fluids. The second article identifies the intermediate and long-term homeostatic mechanisms involved in maintaining the 'acid-ba …
The first in this two-part article explores the short-term homeostatic mechanisms involved in maintaining the 'acid-base balance' of …
Pharmaceuticals targeting nonsense mutations in genetic diseases: progress in development.
Rowe SM, Clancy JP. Rowe SM, et al. Among authors: clancy jp. BioDrugs. 2009;23(3):165-74. doi: 10.2165/00063030-200923030-00003. BioDrugs. 2009. PMID: 19627168 Review.
Several of the published studies in cystic fibrosis have reported improvements in cystic fibrosis transmembrane conductance regulator (CFTR) biomarkers during short-term evaluation, including topical and systemic aminoglycoside treatment, and oral dosing with PTC124. ...
Several of the published studies in cystic fibrosis have reported improvements in cystic fibrosis transmembrane conductance regulator (CFTR) …
A comprehensive aerobiological study of the airborne pollen in the Irish environment.
Markey E, Clancy JH, Martínez-Bracero M, Maya-Manzano JM, Smith M, Skjøth C, Dowding P, Sarda-Estève R, Baisnée D, Donnelly A, McGillicuddy E, Sewell G, O'Connor DJ. Markey E, et al. Among authors: clancy jh. Aerobiologia (Bologna). 2022;38(3):343-366. doi: 10.1007/s10453-022-09751-w. Epub 2022 Jul 28. Aerobiologia (Bologna). 2022. PMID: 36199733 Free PMC article.
Up to now, Ireland has largely refrained from participating in long-term aerobiological studies. Recently, pollen monitoring has commenced in several sampling locations around Ireland. ...
Up to now, Ireland has largely refrained from participating in long-term aerobiological studies. Recently, pollen monitoring has comm …
Long-term amikacin liposome inhalation suspension in cystic fibrosis patients with chronic P. aeruginosa infection.
Bilton D, Fajac I, Pressler T, Clancy JP, Sands D, Minic P, Cipolli M, Galeva I, Solé A, Quittner AL, Jumadilova Z, Ciesielska M, Konstan MW; CLEAR-110 Study Group. Bilton D, et al. Among authors: clancy jp. J Cyst Fibros. 2021 Nov;20(6):1010-1017. doi: 10.1016/j.jcf.2021.05.013. Epub 2021 Jun 16. J Cyst Fibros. 2021. PMID: 34144923 Free PMC article. Clinical Trial.
The CLEAR-110 extension study (ClinicalTrials.gov: NCT01316276; EudraCT: 2011-000443-24) assessed long-term safety, tolerability, and efficacy of ALIS in eligible patients who completed CLEAR-108. ...Mean change from baseline in sputum density of P. aeruginosa at day 672 w …
The CLEAR-110 extension study (ClinicalTrials.gov: NCT01316276; EudraCT: 2011-000443-24) assessed long-term safety, tolerability, and …
Homeostasis, Part 1. Homeostasis versus homeodynamism.
Clancy J, McVicar A. Clancy J, et al. Br J Nurs. 2011 Feb 10-23;20(3):176-82. doi: 10.12968/bjon.2011.20.3.176. Br J Nurs. 2011. PMID: 21378640
All nurses are familiar with the term 'normal', where it concerns the range of figures recorded during assessments and observations of body fluids and organ functioning. ...However, few have heard of 'homeodynamism', which may be a more appropriate term. This articl …
All nurses are familiar with the term 'normal', where it concerns the range of figures recorded during assessments and observations o …
CFTR Modulator Therapies in Pediatric Cystic Fibrosis: Focus on Ivacaftor.
Kramer EL, Clancy JP. Kramer EL, et al. Among authors: clancy jp. Expert Opin Orphan Drugs. 2016 Oct;4(10):1033-1042. doi: 10.1080/21678707.2016.1226800. Epub 2016 Sep 13. Expert Opin Orphan Drugs. 2016. PMID: 28042521 Free PMC article.
Extending these therapies to young CF patients is proposed to have the greatest long term impact, potentially preventing later disease. AREAS COVERED: Here we summarize the research experience of CFTR modulators in pediatrics, focusing on ivacaftor and highlighting challen …
Extending these therapies to young CF patients is proposed to have the greatest long term impact, potentially preventing later diseas …
24 results