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COVID-19-Related Coagulopathy-Is Transferrin a Missing Link?
McLaughlin KM, Bechtel M, Bojkova D, Münch C, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr. McLaughlin KM, et al. Among authors: cinatl j jr. Diagnostics (Basel). 2020 Jul 30;10(8):539. doi: 10.3390/diagnostics10080539. Diagnostics (Basel). 2020. PMID: 32751741 Free PMC article.
To identify gene products that may contribute to COVID-19-related coagulopathy, we analyzed the expression of genes associated with the Gene Ontology (GO) term "blood coagulation" in the Genotype-Tissue Expression (GTEx) database and identified four procoagulants, whose ex …
To identify gene products that may contribute to COVID-19-related coagulopathy, we analyzed the expression of genes associated with the Gene …
A cell culture platform for Cryptosporidium that enables long-term cultivation and new tools for the systematic investigation of its biology.
Miller CN, Jossé L, Brown I, Blakeman B, Povey J, Yiangou L, Price M, Cinatl J Jr, Xue WF, Michaelis M, Tsaousis AD. Miller CN, et al. Among authors: cinatl j jr. Int J Parasitol. 2018 Mar;48(3-4):197-201. doi: 10.1016/j.ijpara.2017.10.001. Epub 2017 Nov 28. Int J Parasitol. 2018. PMID: 29195082 Free PMC article.
Curative therapies and vaccines are lacking, mainly due to lack of a long-term culturing system of this parasite. Here, we show that COLO-680N cells infected with two different Cryptosporidium parvum strains produce sufficient infectious oocysts to infect subsequent cultur …
Curative therapies and vaccines are lacking, mainly due to lack of a long-term culturing system of this parasite. Here, we show that …
Selection of a highly invasive neuroblastoma cell population through long-term human cytomegalovirus infection.
Michaelis M, Barth S, Breitling R, Bruch J, Steinberger D, Rothweiler F, Hackmann K, Schröck E, Doerr HW, Griffin DK, Cinatl J, Cinatl J Jr. Michaelis M, et al. Among authors: cinatl j jr. Oncogenesis. 2012 Apr 30;1(4):e10. doi: 10.1038/oncsis.2012.10. Oncogenesis. 2012. PMID: 23552602 Free PMC article.
Here, we investigated whether the prolonged presence of HCMV can result in the irreversible selection of a cancer cell population with increased malignancy. The neuroblastoma cell line UKF-NB-4 was long-term (200 passages) infected with the HCMV strain Hi91 (UKF-NB-4(Hi)) …
Here, we investigated whether the prolonged presence of HCMV can result in the irreversible selection of a cancer cell population with incre …
Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: a preclinical model.
Kotchetkov R, Cinatl J, Blaheta R, Vogel JU, Karaskova J, Squire J, Hernáiz Driever P, Klingebiel T, Cinatl J Jr. Kotchetkov R, et al. Among authors: cinatl j jr. Int J Cancer. 2003 Mar 10;104(1):36-43. doi: 10.1002/ijc.10917. Int J Cancer. 2003. PMID: 12532417 Free article.
Cytotoxic drug treatment of neuroblastoma often leads to the development of drug resistance and may be associated with increased malignancy. To study the effects of long-term cytotoxic treatment on malignant properties of tumor cells, we established 2 neuroblastoma cell su …
Cytotoxic drug treatment of neuroblastoma often leads to the development of drug resistance and may be associated with increased malignancy. …
Anti-tumor mechanisms of valproate: a novel role for an old drug.
Blaheta RA, Cinatl J Jr. Blaheta RA, et al. Among authors: cinatl j jr. Med Res Rev. 2002 Sep;22(5):492-511. doi: 10.1002/med.10017. Med Res Rev. 2002. PMID: 12210556 Review.
Valproic acid (VPA, 2-propylpentanoic acid) is an established drug in the long-term therapy of epilepsy. During the past years, it has become evident that VPA is also associated with anti-cancer activity. ...
Valproic acid (VPA, 2-propylpentanoic acid) is an established drug in the long-term therapy of epilepsy. During the past years, it ha …
Selective activity of BS-RNase against anaplastic thyroid cancer.
Kotchetkov R, Cinatl J, Krivtchik AA, Vogel JU, Matousek J, Pouckova P, Kornhuber B, Schwabe D, Cinatl J Jr. Kotchetkov R, et al. Among authors: cinatl j jr. Anticancer Res. 2001 Mar-Apr;21(2A):1035-42. Anticancer Res. 2001. PMID: 11396137
The development of effective chemotherapy agents would provide the best chance for long-term survival of patients. MATERIALS AND METHODS: The cytotoxic effects of bovine seminal ribonuclease (BS-RNase) against thyroid carcinoma cell lines with different degrees of differen …
The development of effective chemotherapy agents would provide the best chance for long-term survival of patients. MATERIALS AND METH …
Azidothymidine resistance of H9 human T-cell lymphoma cells is associated with decreased sensitivity to antitumor agents and inhibition of apoptosis.
Cinatl J Jr, Kotchetkov R, Gröschel B, Cinatl J, Driever PH, Kabickova H, Kornhuber B, Schwabe D, Doerr HW. Cinatl J Jr, et al. Int J Mol Med. 1998 Dec;2(6):685-91. doi: 10.3892/ijmm.2.6.685. Int J Mol Med. 1998. PMID: 9850737
In addition the development of tumors and their response to therapy may be further influenced by long-term treatment of HIV-1 patients with nucleoside analogs such as AZT (3'-azido-3'deoxythymidine), ddI (2',3'-dideoxyinosine), ddC (2',3'-dideoxycytidine), d4T (2',3'-dideh …
In addition the development of tumors and their response to therapy may be further influenced by long-term treatment of HIV-1 patient …
Persistent human cytomegalovirus infection induces drug resistance and alteration of programmed cell death in human neuroblastoma cells.
Cinatl J Jr, Cinatl J, Vogel JU, Kotchetkov R, Driever PH, Kabickova H, Kornhuber B, Schwabe D, Doerr HW. Cinatl J Jr, et al. Cancer Res. 1998 Jan 15;58(2):367-72. Cancer Res. 1998. PMID: 9443419
As evidence grows that HCMV interacts with apoptotic signaling due to the interaction of HCMV gene products with cellular proteins of apoptotic pathways, we used human NB cell line UKF-NB-2 persistently infected with HCMV strain AD169 to study the effects of long-term HCMV …
As evidence grows that HCMV interacts with apoptotic signaling due to the interaction of HCMV gene products with cellular proteins of apopto …
Viral and cellular factors for resistance against antiretroviral agents.
Gröschel B, Cinatl J, Cinatl J Jr. Gröschel B, et al. Among authors: cinatl j jr. Intervirology. 1997;40(5-6):400-7. doi: 10.1159/000150572. Intervirology. 1997. PMID: 9675644 Review.
Long-term treatment of HIV-1-infected patients with antiretroviral agents may result in failure of therapy, due to the rapid emergence of resistant virus mutants with decreased susceptibility to therapeutic agents. ...This leads to the assumption that due to long-term …
Long-term treatment of HIV-1-infected patients with antiretroviral agents may result in failure of therapy, due to the rapid emergenc …
Long-term productive human cytomegalovirus infection of a human neuroblastoma cell line.
Cinatl J Jr, Vogel JU, Cinatl J, Weber B, Rabenau H, Novak M, Kornhuber B, Doerr HW. Cinatl J Jr, et al. Int J Cancer. 1996 Jan 3;65(1):90-6. doi: 10.1002/(SICI)1097-0215(19960103)65:1<90::AID-IJC16>3.0.CO;2-M. Int J Cancer. 1996. PMID: 8543403 Free article.
Human neuroblastoma cell line UKF-NB-4 persistently infected with human cytomegalovirus (HCMV) strain AD169 was established to study the effects of long-term HCMV infection on virus production and phenotypic characteristics of tumour cells. ...However, the expression of N- …
Human neuroblastoma cell line UKF-NB-4 persistently infected with human cytomegalovirus (HCMV) strain AD169 was established to study the eff …
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