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Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trial.
Lüthi H, Lengsfeld S, Burkard T, Meienberg A, Jeanloz N, Vukajlovic T, Bologna K, Steinmetz M, Bathelt C, Sailer CO, Laager M, Vogt DR, Hemkens LG, Speich B, Urwyler SA, Kühne J, Baur F, Lutz LN, Erlanger TE, Christ-Crain M, Winzeler B. Lüthi H, et al. Among authors: christ crain m. EClinicalMedicine. 2024 Feb 9;68:102429. doi: 10.1016/j.eclinm.2024.102429. eCollection 2024 Feb. EClinicalMedicine. 2024. PMID: 38371479 Free PMC article.
Herein we report long-term abstinence rates and weight developments after 24 and 52 weeks. ...No treatment-related serious adverse events or deaths occurred. INTERPRETATION: Dulaglutide does not improve long-term smoking abstinence, but has potential to counteract w …
Herein we report long-term abstinence rates and weight developments after 24 and 52 weeks. ...No treatment-related serious adverse ev …
Adjunct prednisone in community-acquired pneumonia: 180-day outcome of a multicentre, double-blind, randomized, placebo-controlled trial.
Blum CA, Roethlisberger EA, Cesana-Nigro N, Winzeler B, Rodondi N, Blum MR, Briel M, Mueller B, Christ-Crain M, Schuetz P. Blum CA, et al. Among authors: christ crain m. BMC Pulm Med. 2023 Dec 11;23(1):500. doi: 10.1186/s12890-023-02794-w. BMC Pulm Med. 2023. PMID: 38082273 Free PMC article. Clinical Trial.
BACKGROUND: Several trials and meta-analyses found a benefit of adjunct corticosteroids for community-acquired pneumonia with respect to short-term outcome, but there is uncertainty about longer-term health effects. Herein, we evaluated clinical outcomes at long …
BACKGROUND: Several trials and meta-analyses found a benefit of adjunct corticosteroids for community-acquired pneumonia with respect to sho …
Glucagon-like peptide-1 analogues: a new way to quit smoking? (SKIP)-a structured summary of a study protocol for a randomized controlled study.
Lengsfeld S, Burkard T, Meienberg A, Jeanloz N, Coynel D, Vogt DR, Hemkens LG, Speich B, Zanchi D, Erlanger TE, Christ-Crain M, Winzeler B. Lengsfeld S, et al. Among authors: christ crain m. Trials. 2023 Apr 20;24(1):284. doi: 10.1186/s13063-023-07164-9. Trials. 2023. PMID: 37081574 Free PMC article.
Further endpoints include post-cessational weight gain, nicotine craving analysis, glucose homeostasis and long-term nicotine abstinence. Two separate substudies assess behavioural, functional and structural changes by functional magnetic resonance imaging and measures of …
Further endpoints include post-cessational weight gain, nicotine craving analysis, glucose homeostasis and long-term nicotine abstine …
Prevalence of Admission Hyponatremia in Patients With Diabetes Treated With and Without an SGLT2 inhibitor.
Monnerat S, Atila C, Refardt J, Christ-Crain M. Monnerat S, et al. Among authors: christ crain m. J Endocr Soc. 2023 Jan 24;7(4):bvad011. doi: 10.1210/jendso/bvad011. eCollection 2023 Feb 9. J Endocr Soc. 2023. PMID: 36819457 Free PMC article.
In 2 randomized double-blind, placebo-controlled trials in patients with the syndrome of inappropriate antidiuresis (SIAD), we showed that empagliflozin increased plasma sodium concentration more effectively than placebo. OBJECTIVE: We hypothesized that long-term therapy w …
In 2 randomized double-blind, placebo-controlled trials in patients with the syndrome of inappropriate antidiuresis (SIAD), we showed that e …
Effects of interleukin-1 antagonism and corticosteroids on fibroblast growth factor-21 in patients with metabolic syndrome.
Ebrahimi F, Urwyler SA, Betz MJ, Christ ER, Schuetz P, Mueller B, Donath MY, Christ-Crain M. Ebrahimi F, et al. Among authors: christ crain m. Sci Rep. 2021 Apr 12;11(1):7911. doi: 10.1038/s41598-021-87207-w. Sci Rep. 2021. PMID: 33846498 Free PMC article. Clinical Trial.
Trial A was an interventional trial (n = 73) investigating short-term effects of the IL-1 antagonist anakinra and of dexamethasone. ...No effect was detectable after longer-term treatment (between-group difference: - 8.8 pg/mL (95%CI - 130.9 to 113.3; p = 0.89). ...
Trial A was an interventional trial (n = 73) investigating short-term effects of the IL-1 antagonist anakinra and of dexamethasone. . …
Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Acromegaly in Routine Clinical Practice in Germany, Austria and Switzerland.
Störmann S, Schopohl J, Bullmann C, Terkamp C, Christ-Crain M, Finke R, Flitsch J, Kreitschmann-Andermahr I, Luger A, Stalla G, Houchard A, Helbig D, Petersenn S. Störmann S, et al. Among authors: christ crain m. Exp Clin Endocrinol Diabetes. 2021 Mar;129(3):224-233. doi: 10.1055/a-1247-4713. Epub 2020 Dec 7. Exp Clin Endocrinol Diabetes. 2021. PMID: 33285601 Free article.
However, it is important to better understand the real-world patient population receiving lanreotide autogel treatment. METHODS: In this non-interventional study the long-term treatment response to lanreotide autogel in adult patients with acromegaly from office-based cent …
However, it is important to better understand the real-world patient population receiving lanreotide autogel treatment. METHODS: In this non …
Risk of Adverse Clinical Outcomes in Hyponatremic Adult Patients Hospitalized for Acute Medical Conditions: A Population-Based Cohort Study.
Kutz A, Ebrahimi F, Aghlmandi S, Wagner U, Bromley M, Illigens B, Siepmann T, Schuetz P, Mueller B, Christ-Crain M. Kutz A, et al. Among authors: christ crain m. J Clin Endocrinol Metab. 2020 Nov 1;105(11):3428-36. doi: 10.1210/clinem/dgaa547. J Clin Endocrinol Metab. 2020. PMID: 32818232 Free PMC article.
CONTEXT: Hyponatremia has been associated with excess long-term morbidity and mortality. However, effects during hospitalization are poorly studied. ...CONCLUSION: In this study, hyponatremia was associated with increased risk of short-term adverse events, primarily …
CONTEXT: Hyponatremia has been associated with excess long-term morbidity and mortality. However, effects during hospitalization are …
Excess Mortality Among Hospitalized Patients With Hypopituitarism-A Population-Based, Matched-Cohort Study.
Ebrahimi F, Kutz A, Wagner U, Illigens B, Siepmann T, Schuetz P, Christ-Crain M, Mueller B, Christ ER. Ebrahimi F, et al. Among authors: christ crain m. J Clin Endocrinol Metab. 2020 Nov 1;105(11):dgaa517. doi: 10.1210/clinem/dgaa517. J Clin Endocrinol Metab. 2020. PMID: 32785679
CONTEXT: Patients with hypopituitarism face excess mortality in the long-term outpatient setting. However, associations of pituitary dysfunction with outcomes in acutely hospitalized patients are lacking. ...
CONTEXT: Patients with hypopituitarism face excess mortality in the long-term outpatient setting. However, associations of pituitary …
IL (Interleukin)-1 Receptor Antagonist Increases Ang (Angiotensin [1-7]) and Decreases Blood Pressure in Obese Individuals.
Urwyler SA, Ebrahimi F, Burkard T, Schuetz P, Poglitsch M, Mueller B, Donath MY, Christ-Crain M. Urwyler SA, et al. Among authors: christ crain m. Hypertension. 2020 Jun;75(6):1455-1463. doi: 10.1161/HYPERTENSIONAHA.119.13982. Epub 2020 Apr 10. Hypertension. 2020. PMID: 32275191 Clinical Trial.
In this explorative study, we examined shorter- (2 days) and longer-term effects (4 weeks) of IL-1 antagonism (anakinra/Kineret) on renin-angiotensin system peptide profiles and on hemodynamic parameters assessed by noninvasive measurement in obese (body mass index 30 kg/m …
In this explorative study, we examined shorter- (2 days) and longer-term effects (4 weeks) of IL-1 antagonism (anakinra/Kineret) on r …
Independent Prognostic Value of MRproANP (Midregional Proatrial Natriuretic Peptide) Levels in Patients With Stroke Is Unaltered Over Time.
Arnold M, Nakas C, Luft A, Christ-Crain M, Leichtle A, Katan M. Arnold M, et al. Among authors: christ crain m. Stroke. 2020 Jun;51(6):1873-1875. doi: 10.1161/STROKEAHA.120.029333. Epub 2020 Mar 27. Stroke. 2020. PMID: 32216532 Clinical Trial.
Change over time does not significantly modify the prognostic value of MRproANP (P=0.65 and P=0.56 for the interaction term in the multivariate model). Conclusions- Independent prognostic value of MRproANP remains unaltered in the acute phase of stroke at least up to 5 day …
Change over time does not significantly modify the prognostic value of MRproANP (P=0.65 and P=0.56 for the interaction term in the mu …
53 results