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Perhexiline Therapy in Patients with Type 2 Diabetes: Incremental Insulin Resistance despite Potentiation of Nitric Oxide Signaling.
Chong CR, Liu S, Imam H, Heresztyn T, Sallustio BC, Chirkov YY, Horowitz JD. Chong CR, et al. Biomedicines. 2022 Sep 23;10(10):2381. doi: 10.3390/biomedicines10102381. Biomedicines. 2022. PMID: 36289640 Free PMC article.
No patient developed symptomatic hypoglycaemia, nor was there any other short-term toxicity of Px. Thus, in patients with stable T2D and cardiovascular disease, Px increases anti-aggregatory responsiveness to NO, but is not an insulin sensitizer, and does not induce hypogl …
No patient developed symptomatic hypoglycaemia, nor was there any other short-term toxicity of Px. Thus, in patients with stable T2D …
Takotsubo Syndrome: Finally Emerging From the Shadows?
Ong GJ, Nguyen TH, Kucia A, Liu SF, Surikow SY, Girolamo O, Chong CR, Chirkov YY, Schenck-Gustafsson K, Frenneaux MP, Horowitz JD. Ong GJ, et al. Among authors: chong cr. Heart Lung Circ. 2021 Jan;30(1):36-44. doi: 10.1016/j.hlc.2020.10.006. Epub 2020 Nov 6. Heart Lung Circ. 2021. PMID: 33168470 Review.
Other major challenges remaining in this area include understanding of the recently demonstrated association between TTS and antecedent cancer, the development of effective treatments to reduce risk of short-term (generally due to shock) and long-term mortality, and …
Other major challenges remaining in this area include understanding of the recently demonstrated association between TTS and antecedent canc …
Stereoselective handling of perhexiline: implications regarding accumulation within the human myocardium.
Chong CR, Drury NE, Licari G, Frenneaux MP, Horowitz JD, Pagano D, Sallustio BC. Chong CR, et al. Eur J Clin Pharmacol. 2015 Dec;71(12):1485-91. doi: 10.1007/s00228-015-1934-8. Epub 2015 Sep 16. Eur J Clin Pharmacol. 2015. PMID: 26376650 Clinical Trial.
The current study sought to (1) determine whether the acute accumulation of perhexiline in the myocardium is stereoselective and (2) investigate the relationship between duration of short-term therapy and the potential stereoselective effects of perhexiline within myocardi …
The current study sought to (1) determine whether the acute accumulation of perhexiline in the myocardium is stereoselective and (2) investi …
Can Perhexiline Be Utilized Without Long-Term Toxicity? A Clinical Practice Audit.
Phuong H, Choi BY, Chong CR, Raman B, Horowitz JD. Phuong H, et al. Among authors: chong cr. Ther Drug Monit. 2016 Feb;38(1):73-8. doi: 10.1097/FTD.0000000000000237. Ther Drug Monit. 2016. PMID: 26309031
Its benefits on myocardial energetics state are potentially counter-balanced by risk of hepatotoxicity and peripheral neuropathy during long-term treatment if drug accumulation occurs. Since perhexiline exhibits complex pharmacokinetics with wide inter-individual variabili …
Its benefits on myocardial energetics state are potentially counter-balanced by risk of hepatotoxicity and peripheral neuropathy during long …