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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1991 2
1993 1
1997 2
1999 1
2000 1
2002 1
2003 1
2004 1
2006 1
2007 2
2009 1
2014 1
2015 2
2016 2
2018 4
2019 1
2021 2
2023 2
2024 1

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28 results

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Page 1
Pharmacotherapy for Seizures in Tuberous Sclerosis Complex.
Nabbout R, Kuchenbuch M, Chiron C, Curatolo P. Nabbout R, et al. Among authors: chiron c. CNS Drugs. 2021 Sep;35(9):965-983. doi: 10.1007/s40263-021-00835-8. Epub 2021 Aug 21. CNS Drugs. 2021. PMID: 34417984 Review.
Indeed, epilepsy linked to TSC is one of the only epilepsies for which a predictive and preventive approach can delay seizure onset and improve seizure response. However, the efficacy of such interventions on long-term cognitive and psychiatric outcomes is still under inve …
Indeed, epilepsy linked to TSC is one of the only epilepsies for which a predictive and preventive approach can delay seizure onset and impr …
Stiripentol for the treatment of seizures associated with Dravet syndrome.
Chiron C. Chiron C. Expert Rev Neurother. 2019 Apr;19(4):301-310. doi: 10.1080/14737175.2019.1593142. Epub 2019 Apr 2. Expert Rev Neurother. 2019. PMID: 30900478 Review.
Therapeutic options recently grew in this rare and severe early-onset epilepsy with the approval of stiripentol and cannabidiol in 2018 in the US and the positive trials just completed with fenfluramine. Areas covered: First, the short-term efficacy of stiripentol as adjun …
Therapeutic options recently grew in this rare and severe early-onset epilepsy with the approval of stiripentol and cannabidiol in 2018 in t …
Pharmacology aspects during transition and at transfer in patients with epilepsy.
Chiron C, An I. Chiron C, et al. Epilepsia. 2014 Aug;55 Suppl 3:8-11. doi: 10.1111/epi.12708. Epilepsia. 2014. PMID: 25209078 Free article. Review.
As an initial step to answer this problem, we reviewed the controlled trials of antiepileptic drugs (AEDs) independently performed in adults and children for a given syndrome. Then we reviewed the longitudinal long-term course in the various epilepsy syndromes. Optimizing …
As an initial step to answer this problem, we reviewed the controlled trials of antiepileptic drugs (AEDs) independently performed in adults …
Safety considerations selecting antiseizure medications for the treatment of individuals with Dravet syndrome.
Nabbout R, Chemaly N, Chiron C, Kuchenbuch M. Nabbout R, et al. Among authors: chiron c. Expert Opin Drug Saf. 2021 May;20(5):561-576. doi: 10.1080/14740338.2021.1890025. Epub 2021 Feb 28. Expert Opin Drug Saf. 2021. PMID: 33645379 Review.
Progress has been made in understanding the pathophysiology, the long-term outcome and possible consequences of inappropriate therapies, new drugs have been approved by the regulatory authorities and patients and families expressed their needs beyond seizures' control.Area …
Progress has been made in understanding the pathophysiology, the long-term outcome and possible consequences of inappropriate therapi …
Initiating stiripentol before 2 years of age in patients with Dravet syndrome is safe and beneficial against status epilepticus.
Chiron C, Chemaly N, Chancharme L, Nabbout R. Chiron C, et al. Dev Med Child Neurol. 2023 Dec;65(12):1607-1616. doi: 10.1111/dmcn.15638. Epub 2023 May 17. Dev Med Child Neurol. 2023. PMID: 37198755
With long-term therapy (last visit on stiripentol <7 years of age, median stiripentol 28 months, median age 41 months), the frequency of long-lasting TCS continued to decline (p = 0.03). Emergency hospitalizations dropped from 91% to 43% and 12% with short- and long- …
With long-term therapy (last visit on stiripentol <7 years of age, median stiripentol 28 months, median age 41 months), the freque …
Fifteen years of real-world data on the use of vigabatrin in individuals with infantile epileptic spasms syndrome.
Kuchenbuch M, Lo Barco T, Chemaly N, Chiron C, Nabbout R. Kuchenbuch M, et al. Among authors: chiron c. Epilepsia. 2024 Feb;65(2):430-444. doi: 10.1111/epi.17808. Epub 2023 Dec 20. Epilepsia. 2024. PMID: 37872396
Clinical, EEG, imaging, and biological data were extracted from the EHRs. We analyzed factors associated with short-term response, time to response, relapse, time to relapse of spasms, and the presence of spasms at last follow-up. ...
Clinical, EEG, imaging, and biological data were extracted from the EHRs. We analyzed factors associated with short-term response, ti …
[Treatment protocol for long-term anti-epilepsy drugs in children with refractory epilepsy].
Dulac O, Chiron C. Dulac O, et al. Among authors: chiron c. Rev Neurol (Paris). 2004 Jun;160 Spec No 1:5S265-71. Rev Neurol (Paris). 2004. PMID: 15331974 Review. French.
Long-term treatment of children with drug-resistant epilepsy has not been addressed in detail in the literature. ...
Long-term treatment of children with drug-resistant epilepsy has not been addressed in detail in the literature. ...
Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation.
Chemaly N, Losito E, Pinard JM, Gautier A, Villeneuve N, Arbues AS, An I, Desguerre I, Dulac O, Chiron C, Kaminska A, Nabbout R. Chemaly N, et al. Among authors: chiron c. Epileptic Disord. 2018 Dec 1;20(6):457-467. doi: 10.1684/epd.2018.1009. Epileptic Disord. 2018. PMID: 30530412
Early recognition of the above features should improve early diagnosis and long-term management of patients with epilepsy and PCDH19 mutations....
Early recognition of the above features should improve early diagnosis and long-term management of patients with epilepsy and PCDH19 …
Do children with Dravet syndrome continue to benefit from stiripentol for long through adulthood?
Chiron C, Helias M, Kaminska A, Laroche C, de Toffol B, Dulac O, Nabbout R, An I. Chiron C, et al. Epilepsia. 2018 Sep;59(9):1705-1717. doi: 10.1111/epi.14536. Epub 2018 Aug 22. Epilepsia. 2018. PMID: 30132836
SIGNIFICANCE: The efficacy and safety of the stiripentol/valproate/clobazam combination started at pediatric age are maintained at very long term during adulthood. Such prolonged stiripentol therapy tends to positively impact the late prognosis of epilepsy, especially when …
SIGNIFICANCE: The efficacy and safety of the stiripentol/valproate/clobazam combination started at pediatric age are maintained at very long …
28 results