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Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma.
Koch MS, Zdioruk M, Nowicki MO, Griffith AM, Aguilar-Cordova E, Aguilar LK, Guzik BW, Barone F, Tak PP, Schregel K, Hoetker MS, Lederer JA, Chiocca EA, Tabatabai G, Lawler SE. Koch MS, et al. Among authors: chiocca ea. Mol Ther Oncolytics. 2022 Jul 31;26:275-288. doi: 10.1016/j.omto.2022.07.009. eCollection 2022 Sep 15. Mol Ther Oncolytics. 2022. PMID: 36032633 Free PMC article.
In vitro, we observed a significant increase in the DNA-damage marker gammaH2AX and decreased expression of PD-L1, pro-tumorigenic cytokines (interleukin-1beta [IL-1beta], IL-4), and ligand NKG2D after combination treatment compared with monotherapy or control. In vivo, long-t …
In vitro, we observed a significant increase in the DNA-damage marker gammaH2AX and decreased expression of PD-L1, pro-tumorigenic cytokines …
STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models.
Berger G, Knelson EH, Jimenez-Macias JL, Nowicki MO, Han S, Panagioti E, Lizotte PH, Adu-Berchie K, Stafford A, Dimitrakakis N, Zhou L, Chiocca EA, Mooney DJ, Barbie DA, Lawler SE. Berger G, et al. Among authors: chiocca ea. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2111003119. doi: 10.1073/pnas.2111003119. Epub 2022 Jul 5. Proc Natl Acad Sci U S A. 2022. PMID: 35787058 Free PMC article.
Treatment of established murine intracranial GL261 and CT-2A tumors by biodegradable ADU-S100-loaded intracranial implants demonstrated a significant increase in survival in both models and long-term survival with immune memory in GL261. Responses to treatment were abolish …
Treatment of established murine intracranial GL261 and CT-2A tumors by biodegradable ADU-S100-loaded intracranial implants demonstrated a si …
Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment.
Jackson JW, Hall BL, Marzulli M, Shah VK, Bailey L, Chiocca EA, Goins WF, Kohanbash G, Cohen JB, Glorioso JC. Jackson JW, et al. Among authors: chiocca ea. Mol Ther Oncolytics. 2021 Jul 29;22:444-453. doi: 10.1016/j.omto.2021.07.009. eCollection 2021 Sep 24. Mol Ther Oncolytics. 2021. PMID: 34553031 Free PMC article.
Furthermore, the CT2A model was completely resistant to virus therapy, while in the GL261N4 model rQNestin34.5v1 treatment resulted in enhanced macrophage recruitment, impaired tumor progression, and long-term survival of a few animals. We conclude that prolonged intratumo …
Furthermore, the CT2A model was completely resistant to virus therapy, while in the GL261N4 model rQNestin34.5v1 treatment resulted in enhan …
Biographies of international women leaders in neurosurgery.
Casillo SM, Venkatesh A, Muthiah N, Agarwal N, Scott T, Romani R, Fernández LL, Aristizabal S, Ginalis EE, Ozair A, Bhat V, Faruqi A, Bajaj A, Sonkar AA, Ikeda DS, Chiocca EA, Lonser RR, Sutton TE, McGregor JM, Rea GL, Schunemann VA, Ngwenya LB, Marlin ES, Porensky PN, Shaikhouni A, Huntoon K, Dornbos D, Shaw AB, Powers CJ, Gluski JM, Culver LG, Goodwin AM, Ham S, Marupudi NI, Bhat DI, Berry KM, Wu EM, Wang MY. Casillo SM, et al. Among authors: chiocca ea. Neurosurg Focus. 2021 Mar;50(3):E19. doi: 10.3171/2021.1.FOCUS201096. Neurosurg Focus. 2021. PMID: 33789227
When choosing their life's work, they chose service, often of the most neglected-those with pain, trauma, and disability. These women inspire and point the way to a time when the term "women leaders" as an exception is unnecessary.-Katharine J. ...
When choosing their life's work, they chose service, often of the most neglected-those with pain, trauma, and disability. These women inspir …
Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-κB/STAT3 Signaling.
Schweiger MW, Li M, Giovanazzi A, Fleming RL, Tabet EI, Nakano I, Würdinger T, Chiocca EA, Tian T, Tannous BA. Schweiger MW, et al. Among authors: chiocca ea. Adv Biosyst. 2020 Dec;4(12):e1900312. doi: 10.1002/adbi.201900312. Epub 2020 Jun 9. Adv Biosyst. 2020. PMID: 32519463 Free PMC article.
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long-term survival remains uncommon. GBM can be roughly divided into three different molecular subtypes, each varying in aggressiveness and treatment resistance. ...
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long-term survival remains uncommo …
GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-tumor Activity and Animal Survival.
Sette P, Amankulor N, Li A, Marzulli M, Leronni D, Zhang M, Goins WF, Kaur B, Bolyard C, Cripe TP, Yu J, Chiocca EA, Glorioso JC, Grandi P. Sette P, et al. Among authors: chiocca ea. Mol Ther Oncolytics. 2019 Oct 24;15:214-222. doi: 10.1016/j.omto.2019.10.005. eCollection 2019 Dec 20. Mol Ther Oncolytics. 2019. PMID: 31890868 Free PMC article.
We show that vector-expressed MMP9 enhanced therapeutic efficacy and long-term animal survival in a GBM xenograft model....
We show that vector-expressed MMP9 enhanced therapeutic efficacy and long-term animal survival in a GBM xenograft model....
Viral and other therapies for recurrent glioblastoma: is a 24-month durable response unusual?
Chiocca EA, Nassiri F, Wang J, Peruzzi P, Zadeh G. Chiocca EA, et al. Neuro Oncol. 2019 Jan 1;21(1):14-25. doi: 10.1093/neuonc/noy170. Neuro Oncol. 2019. PMID: 30346600 Free PMC article. Review.
Other modalities have also reported a "tail" of seemingly long-term survivors. These trials seem to show that these responder "tails" characterize a defined subset of GBM patients....
Other modalities have also reported a "tail" of seemingly long-term survivors. These trials seem to show that these responder "tails" …
Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models.
Berger G, Grauwet K, Zhang H, Hussey AM, Nowicki MO, Wang DI, Chiocca EA, Lawler SE, Lippard SJ. Berger G, et al. Among authors: chiocca ea. Cancer Lett. 2018 Mar 1;416:138-148. doi: 10.1016/j.canlet.2017.11.041. Epub 2017 Dec 13. Cancer Lett. 2018. PMID: 29246647
Glioblastoma is the most prevalent and lethal primary intrinsic brain tumor with a median patient survival of less than two years, even with the optimal standard of care, namely, surgical resection followed by radiotherapy with adjuvant temozolomide chemotherapy. Long-term …
Glioblastoma is the most prevalent and lethal primary intrinsic brain tumor with a median patient survival of less than two years, even with …
Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma.
Speranza MC, Passaro C, Ricklefs F, Kasai K, Klein SR, Nakashima H, Kaufmann JK, Ahmed AK, Nowicki MO, Obi P, Bronisz A, Aguilar-Cordova E, Aguilar LK, Guzik BW, Breakefield X, Weissleder R, Freeman GJ, Reardon DA, Wen PY, Chiocca EA, Lawler SE. Speranza MC, et al. Among authors: chiocca ea. Neuro Oncol. 2018 Jan 22;20(2):225-235. doi: 10.1093/neuonc/nox139. Neuro Oncol. 2018. PMID: 29016938 Free PMC article.
Both GMCI and anti-PD-1 increased intratumoral T-cell infiltration. A higher percentage of long-term survivors was observed in mice treated with combined GMCI/anti-PD-1 relative to single treatments. Long-term survivors were protected from tumor rechallenge, demonst …
Both GMCI and anti-PD-1 increased intratumoral T-cell infiltration. A higher percentage of long-term survivors was observed in mice t …
Extracranial growth of glioblastoma multiforme.
Forsyth TM, Bi WL, Abedalthagafi M, Dunn IF, Chiocca EA. Forsyth TM, et al. Among authors: chiocca ea. J Clin Neurosci. 2015 Sep;22(9):1521-3. doi: 10.1016/j.jocn.2015.03.018. Epub 2015 May 5. J Clin Neurosci. 2015. PMID: 25956620
Emerging data on circulating tumor cells in GBM patients indicate that extraaxial metastasis may be part of the disease course in some, particularly in long term survivors. Furthermore, the proximity of calvarial and scalp lesions to previous surgical sites and the time co …
Emerging data on circulating tumor cells in GBM patients indicate that extraaxial metastasis may be part of the disease course in some, part …
23 results