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Ex Vivo-expanded Natural Killer Cells Derived From Long-term Cryopreserved Cord Blood are Cytotoxic Against Primary Breast Cancer Cells.
Nham T, Poznanski SM, Fan IY, Vahedi F, Shenouda MM, Lee AJ, Chew MV, Hogg RT, Lee DA, Ashkar AA. Nham T, et al. Among authors: chew mv. J Immunother. 2018 Feb/Mar;41(2):64-72. doi: 10.1097/CJI.0000000000000192. J Immunother. 2018. PMID: 29189387
We compared the expansion potential and antitumor effector function of CB-derived NK (CB-NK) cells expanded from fresh (n=4), short-term cryopreserved (<1-year old, n=5), and long-term cryopreserved (1-10-year old, n=5) CB. ...Therefore, we propose that long-t …
We compared the expansion potential and antitumor effector function of CB-derived NK (CB-NK) cells expanded from fresh (n=4), short-term …
Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice.
Dykstra C, Lee AJ, Lusty EJ, Shenouda MM, Shafai M, Vahedi F, Chew MV, Collins S, Ashkar AA. Dykstra C, et al. Among authors: chew mv. BMC Immunol. 2016 Jun 16;17(1):18. doi: 10.1186/s12865-016-0157-9. BMC Immunol. 2016. PMID: 27307066 Free PMC article.
Adult and newborn engrafted humanized mice were comparable in long-term reconstitution of human CD45 cells and subsequent lymphoid and myeloid subsets in the spleen, bone marrow, thymus, lymph node, and liver. ...
Adult and newborn engrafted humanized mice were comparable in long-term reconstitution of human CD45 cells and subsequent lymphoid an …
Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.
Gillgrass AE, Chew MV, Krneta T, Ashkar AA. Gillgrass AE, et al. Among authors: chew mv. BMC Cancer. 2015 Apr 16;15:293. doi: 10.1186/s12885-015-1264-3. BMC Cancer. 2015. PMID: 25879689 Free PMC article.
CD8 T cells in IL-15 TG/MT tumors were capable of secreting IFNgamma, possessed markers of memory, did not display an exhausted phenotype and were frequently NK1.1+. Long-term antibody depletion studies in IL-15 TG/MT mice revealed that NK1.1+, but not CD8 T cells, were cr …
CD8 T cells in IL-15 TG/MT tumors were capable of secreting IFNgamma, possessed markers of memory, did not display an exhausted phenotype an …
Genital HSV-2 infection induces short-term NK cell memory.
Abdul-Careem MF, Lee AJ, Pek EA, Gill N, Gillgrass AE, Chew MV, Reid S, Ashkar AA. Abdul-Careem MF, et al. Among authors: chew mv. PLoS One. 2012;7(3):e32821. doi: 10.1371/journal.pone.0032821. Epub 2012 Mar 22. PLoS One. 2012. PMID: 22457721 Free PMC article.