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Neurosurgeons Deliver Similar Quality Care Regardless of First Assistant Type: Resident Physician versus Nonphysician Surgical Assistant.
Ng GY, Gallagher RS, Borja AJ, Jabarkheel R, Na J, McClintock SD, Chen HI, Petrov D, Jankowitz BT, Malhotra NR. Ng GY, et al. Among authors: chen hi. World Neurosurg. 2023 Jun;174:e144-e151. doi: 10.1016/j.wneu.2023.03.023. Epub 2023 Mar 10. World Neurosurg. 2023. PMID: 36907269
CONCLUSIONS: For single-level posterior spinal fusion, in the setting described, there are no differences in short-term patient outcomes delivered by attending surgeons assisted by resident physicians versus NPSAs....
CONCLUSIONS: For single-level posterior spinal fusion, in the setting described, there are no differences in short-term patient outco …
Axonal Tract Reconstruction Using a Tissue-Engineered Nigrostriatal Pathway in a Rat Model of Parkinson's Disease.
Struzyna LA, Browne KD, Burrell JC, Vélez WJG, Wofford KL, Kaplan HM, Murthy NS, Chen HI, Duda JE, España RA, Cullen DK. Struzyna LA, et al. Among authors: chen hi. Int J Mol Sci. 2022 Nov 12;23(22):13985. doi: 10.3390/ijms232213985. Int J Mol Sci. 2022. PMID: 36430464 Free PMC article.
This work showed proof of concept that TE-NSPs can reconstruct the nigrostriatal pathway, providing motivation for future studies evaluating potential functional benefits and long-term durability of this strategy. This pathway reconstruction strategy may ultimately replace …
This work showed proof of concept that TE-NSPs can reconstruct the nigrostriatal pathway, providing motivation for future studies evaluating …
Predicting short-term outcomes following supratentorial tumor surgery.
Winter E, Dimentberg R, Haldar D, Glauser G, Caplan IF, Shultz K, McClintock SD, Chen HI, Yoon JW, Malhotra NR. Winter E, et al. Among authors: chen hi. Clin Neurol Neurosurg. 2020 Sep;196:106016. doi: 10.1016/j.clineuro.2020.106016. Epub 2020 Jun 20. Clin Neurol Neurosurg. 2020. PMID: 32619899
OBJECTIVES: The LACE+ index risk prediction tool has not been successfully used to predict short-term outcomes after neurosurgery. This study assessed the ability of LACE+ to predict 30-day (30D) adverse outcomes after supratentorial brain tumor surgery. ...CONCLUSION: LAC …
OBJECTIVES: The LACE+ index risk prediction tool has not been successfully used to predict short-term outcomes after neurosurgery. Th …
Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation.
Qian X, Su Y, Adam CD, Deutschmann AU, Pather SR, Goldberg EM, Su K, Li S, Lu L, Jacob F, Nguyen PTT, Huh S, Hoke A, Swinford-Jackson SE, Wen Z, Gu X, Pierce RC, Wu H, Briand LA, Chen HI, Wolf JA, Song H, Ming GL. Qian X, et al. Among authors: chen hi. Cell Stem Cell. 2020 May 7;26(5):766-781.e9. doi: 10.1016/j.stem.2020.02.002. Epub 2020 Mar 5. Cell Stem Cell. 2020. PMID: 32142682 Free PMC article.
Here, we report the sliced neocortical organoid (SNO) system, which bypasses the diffusion limit to prevent cell death over long-term cultures. This method leads to sustained neurogenesis and formation of an expanded cortical plate that establishes distinct upper and deep …
Here, we report the sliced neocortical organoid (SNO) system, which bypasses the diffusion limit to prevent cell death over long-term …
Transplantation of Human Brain Organoids: Revisiting the Science and Ethics of Brain Chimeras.
Chen HI, Wolf JA, Blue R, Song MM, Moreno JD, Ming GL, Song H. Chen HI, et al. Cell Stem Cell. 2019 Oct 3;25(4):462-472. doi: 10.1016/j.stem.2019.09.002. Cell Stem Cell. 2019. PMID: 31585092 Free PMC article. Review.
This practical approach suggests that augmentation of discrete brain functions in transplant hosts is a more relevant ethical question in the near term than the possibility of "conscious" chimeric animals. We hope that this framework contributes to a balanced approach for …
This practical approach suggests that augmentation of discrete brain functions in transplant hosts is a more relevant ethical question in th …
Multichannel Silicon Probes for Awake Hippocampal Recordings in Large Animals.
Ulyanova AV, Cottone C, Adam CD, Gagnon KG, Cullen DK, Holtzman T, Jamieson BG, Koch PF, Chen HI, Johnson VE, Wolf JA. Ulyanova AV, et al. Among authors: chen hi. Front Neurosci. 2019 Apr 26;13:397. doi: 10.3389/fnins.2019.00397. eCollection 2019. Front Neurosci. 2019. PMID: 31080400 Free PMC article.
This study provides an analysis of multichannel silicon probes designed for large animal electrophysiology of deep laminar brain structures, and suggests that current designs are reaching the physical thresholds necessary for long-term (1 month) recordings with single-unit …
This study provides an analysis of multichannel silicon probes designed for large animal electrophysiology of deep laminar brain structures, …
Patterns of opioid use in patients with trigeminal neuralgia undergoing neurosurgery.
Yang AI, McShane BJ, Hitti FL, Sandhu SK, Chen HI, Lee JYK. Yang AI, et al. Among authors: chen hi. J Neurosurg. 2019 Jan 11;131(6):1805-1811. doi: 10.3171/2018.8.JNS1893. J Neurosurg. 2019. PMID: 30641832

Neurosurgical intervention led to a reduction in opioid use to 8% at long-term follow-up (p < 0.01, Fisher's exact test; n = 154). Diagnosis (for diagnoses other than TN1, OR 4.7, p = 0.002) and postintervention reduction in pain at its worst (for each unit reduction, O

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Neurosurgical intervention led to a reduction in opioid use to 8% at long-term follow-up (p < 0.01, Fisher's exact test; n = 154).

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Engineered Axonal Tracts as "Living Electrodes" for Synaptic-Based Modulation of Neural Circuitry.
Serruya MD, Harris JP, Adewole DO, Struzyna LA, Burrell JC, Nemes A, Petrov D, Kraft RH, Chen HI, Wolf JA, Cullen DK. Serruya MD, et al. Among authors: chen hi. Adv Funct Mater. 2018 Mar 21;28(12):1701183. doi: 10.1002/adfm.201701183. Epub 2017 Sep 4. Adv Funct Mater. 2018. PMID: 34045935 Free PMC article.
Current efforts are assessing the efficacy of this biohybrid interface for targeted, synaptic-based neuromodulation, and the specificity, spatial density and long-term fidelity versus conventional microelectronic or optical substrates alone....
Current efforts are assessing the efficacy of this biohybrid interface for targeted, synaptic-based neuromodulation, and the specificity, sp …
Gait Speed rather than Dynapenia Is a Simple Indicator for Complex Care Needs: A Cross-sectional Study Using Minimum Data Set.
Huang TY, Liang CK, Shen HC, Chen HI, Liao MC, Chou MY, Lin YT, Chen LK. Huang TY, et al. Among authors: chen hi. Sci Rep. 2017 Aug 21;7(1):8418. doi: 10.1038/s41598-017-08791-4. Sci Rep. 2017. PMID: 28827697 Free PMC article.
The impact of dynapenia on the complexity of care for residents of long-term care facilities (LTCF) remains unclear. The present study evaluated associations between dynapenia, care problems and care complexity in 504 residents of Veterans Care Homes (VCHs) in Taiwan. ...
The impact of dynapenia on the complexity of care for residents of long-term care facilities (LTCF) remains unclear. The present stud …
Hemodynamic mechanism of ventricular hypertrophy in hypertension.
Chen HI. Chen HI. Chin J Physiol. 2012 Dec 31;55(6):369-79. doi: 10.4077/cjp.2012.baa088. Chin J Physiol. 2012. PMID: 23286444
We compared the endothelium-dependent and -independent vasodilation to acetylcholine, sodium nitroprusside and S-nitroso-N-acetylpenicillanine and the endothelium-dependent or -independent vasoconstriction to norepinephrine and phenylephrine between SHR and normotensive Wistar Ky …
We compared the endothelium-dependent and -independent vasodilation to acetylcholine, sodium nitroprusside and S-nitroso-N-acetylpenicillani …
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