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Unveiling the dynamics of the breast milk microbiome: impact of lactation stage and gestational age.
Singh P, Al Mohannadi N, Murugesan S, Almarzooqi F, Kabeer BSA, Marr AK, Kino T, Brummaier T, Terranegra A, McGready R, Nosten F, Chaussabel D, Al Khodor S. Singh P, et al. Among authors: chaussabel d. J Transl Med. 2023 Nov 6;21(1):784. doi: 10.1186/s12967-023-04656-9. J Transl Med. 2023. PMID: 37932773 Free PMC article.
We compared these samples with BM samples from healthy term pregnancies across different lactation stages (colostrum, transitional and mature milk) using 16S rRNA gene sequencing. ...CONCLUSION: Our study underscores the significant influence of pregnancy-related complicat …
We compared these samples with BM samples from healthy term pregnancies across different lactation stages (colostrum, transitional an …
Vaginal Microbiota and Cytokine Levels Predict Preterm Delivery in Asian Women.
Kumar M, Murugesan S, Singh P, Saadaoui M, Elhag DA, Terranegra A, Kabeer BSA, Marr AK, Kino T, Brummaier T, McGready R, Nosten F, Chaussabel D, Al Khodor S. Kumar M, et al. Among authors: chaussabel d. Front Cell Infect Microbiol. 2021 Mar 4;11:639665. doi: 10.3389/fcimb.2021.639665. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 33747983 Free PMC article.
Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. ...Differences in the vaginal microbial diversity and local vaginal immune environment were associated with greater risk of preterm birth. Our findings highlight new opportun …
Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. ...Differences in the vaginal microbial d …
Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting.
Huang SSY, Makhlouf M, AbouMoussa EH, Ruiz Tejada Segura ML, Mathew LS, Wang K, Leung MC, Chaussabel D, Logan DW, Scialdone A, Garand M, Saraiva LR. Huang SSY, et al. Among authors: chaussabel d. Mol Metab. 2020 Oct;40:101038. doi: 10.1016/j.molmet.2020.101038. Epub 2020 Jun 8. Mol Metab. 2020. PMID: 32526449 Free PMC article.
Fasting alters metabolism by acting as a reset for energy homeostasis, but the molecular mechanisms underlying the beneficial effects of short-term fasting (STF) are not well understood, particularly at the systems or multiorgan level. ...CONCLUSIONS: Our study provides a …
Fasting alters metabolism by acting as a reset for energy homeostasis, but the molecular mechanisms underlying the beneficial effects of sho …
A prospective cohort for the investigation of alteration in temporal transcriptional and microbiome trajectories preceding preterm birth: a study protocol.
Brummaier T, Syed Ahamed Kabeer B, Lindow S, Konje JC, Pukrittayaamee S, Utzinger J, Toufiq M, Antoniou A, Marr AK, Suriyakan S, Kino T, Al Khodor S, Terranegra A, Nosten F, Paris DH, McGready R, Chaussabel D. Brummaier T, et al. Among authors: chaussabel d. BMJ Open. 2019 Jan 15;9(1):e023417. doi: 10.1136/bmjopen-2018-023417. BMJ Open. 2019. PMID: 30782707 Free PMC article.
In a nested case-control analysis, perturbations of transcript abundance in capillary blood as well as longitudinal changes of the gut, vaginal and oral microbiome will be compared between mothers giving birth to preterm and matched cases giving birth to term …
In a nested case-control analysis, perturbations of transcript abundance in capillary blood as well as longitudinal changes of the gut, vagi …
Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts.
Della Mina E, Borghesi A, Zhou H, Bougarn S, Boughorbel S, Israel L, Meloni I, Chrabieh M, Ling Y, Itan Y, Renieri A, Mazzucchelli I, Basso S, Pavone P, Falsaperla R, Ciccone R, Cerbo RM, Stronati M, Picard C, Zuffardi O, Abel L, Chaussabel D, Marr N, Li X, Casanova JL, Puel A. Della Mina E, et al. Among authors: chaussabel d. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E514-E523. doi: 10.1073/pnas.1620139114. Epub 2017 Jan 9. Proc Natl Acad Sci U S A. 2017. PMID: 28069966 Free PMC article.
By contrast, the patient's peripheral blood mononuclear cells responded normally to all TLR1/2, TLR2/6, TLR4, TLR7, and TLR8 (R848) agonists tested, and to IL-1beta. The death of this child precluded long-term evaluations of the clinical consequences of inherited IRAK-1 de …
By contrast, the patient's peripheral blood mononuclear cells responded normally to all TLR1/2, TLR2/6, TLR4, TLR7, and TLR8 (R848) agonists …
Transcriptional network predicts viral set point during acute HIV-1 infection.
Chang HH, Soderberg K, Skinner JA, Banchereau J, Chaussabel D, Haynes BF, Ramoni M, Letvin NL. Chang HH, et al. Among authors: chaussabel d. J Am Med Inform Assoc. 2012 Nov-Dec;19(6):1103-9. doi: 10.1136/amiajnl-2012-000867. Epub 2012 Jun 14. J Am Med Inform Assoc. 2012. PMID: 22700869 Free PMC article.
Predicting viral set point early following infection can contribute to our understanding of early control of HIV-1 replication, to predicting long-term clinical outcomes, and to the choice of optimal therapeutic regimens. ...
Predicting viral set point early following infection can contribute to our understanding of early control of HIV-1 replication, to predictin …
A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial).
Quartier P, Allantaz F, Cimaz R, Pillet P, Messiaen C, Bardin C, Bossuyt X, Boutten A, Bienvenu J, Duquesne A, Richer O, Chaussabel D, Mogenet A, Banchereau J, Treluyer JM, Landais P, Pascual V. Quartier P, et al. Among authors: chaussabel d. Ann Rheum Dis. 2011 May;70(5):747-54. doi: 10.1136/ard.2010.134254. Epub 2010 Dec 20. Ann Rheum Dis. 2011. PMID: 21173013 Free PMC article. Clinical Trial.
CONCLUSIONS: Anakinra treatment is effective in SJIA, at least in the short term. It is associated with normalisation of blood gene expression profiles in clinical responders and induces a de novo IFN signature. ...
CONCLUSIONS: Anakinra treatment is effective in SJIA, at least in the short term. It is associated with normalisation of blood gene e …
Biomedical literature mining: challenges and solutions in the 'omics' era.
Chaussabel D. Chaussabel D. Am J Pharmacogenomics. 2004;4(6):383-93. doi: 10.2165/00129785-200404060-00005. Am J Pharmacogenomics. 2004. PMID: 15651899
In addition, a literature mining strategy has been developed to explore patterns of term occurrences in abstracts. This method automatically identifies relevant keywords in collections of abstracts, and uses a pattern discovery algorithm to generate a visual interface for …
In addition, a literature mining strategy has been developed to explore patterns of term occurrences in abstracts. This method automa …
Mining microarray expression data by literature profiling.
Chaussabel D, Sher A. Chaussabel D, et al. Genome Biol. 2002 Sep 13;3(10):RESEARCH0055. doi: 10.1186/gb-2002-3-10-research0055. Epub 2002 Sep 13. Genome Biol. 2002. PMID: 12372143 Free PMC article.
Such data treatment also provides information on the nature and pertinence of the associations that were formed. CONCLUSIONS: The analysis of patterns of term occurrence in abstracts constitutes a means of exploring the biological significance of large and heterogeneous li …
Such data treatment also provides information on the nature and pertinence of the associations that were formed. CONCLUSIONS: The analysis o …