The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery.
Lamson NG, Fein KC, Gleeson JP, Newby AN, Xian S, Cochran K, Chaudhary N, Melamed JR, Ball RL, Suri K, Ahuja V, Zhang A, Berger A, Kolodieznyi D, Schmidt BF, Silva GL, Whitehead KA.
Lamson NG, et al. Among authors: chaudhary n.
Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2207829119. doi: 10.1073/pnas.2207829119. Epub 2022 Aug 9.
Proc Natl Acad Sci U S A. 2022.
PMID: 35943988
Free PMC article.
One potential solution is codelivery of macromolecules, including therapeutic proteins or nucleic acids, with intestinal permeation enhancers; however, enhancer use has been limited clinically by modest efficacy and toxicity concerns surrounding long-term administration. H …
One potential solution is codelivery of macromolecules, including therapeutic proteins or nucleic acids, with intestinal permeation enhancer …