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Oesophageal stasis is a risk factor for chronic lung allograft dysfunction and allograft failure in lung transplant recipients.
Ramendra R, Fernández-Castillo JC, Huszti E, Ghany R, Aversa M, Havlin J, Riddell P, Chaparro CM, Singer LG, Liu L, Keshavjee S, Yeung JC, Martinu T. Ramendra R, et al. Among authors: chaparro cm. ERJ Open Res. 2023 Sep 10;9(5):00222-2023. doi: 10.1183/23120541.00222-2023. eCollection 2023 Sep. ERJ Open Res. 2023. PMID: 37817870 Free PMC article.
Herein, we sought to investigate the relationship between oesophageal motility disorders and long-term outcomes in a large retrospective cohort of lung transplant recipients. ...CONCLUSION: Lung transplant recipients with oesophageal stasis characterised by OGJOO or major …
Herein, we sought to investigate the relationship between oesophageal motility disorders and long-term outcomes in a large retrospect …
Extending the age criteria of lung transplant donors to 70+ years old does not significantly affect recipient survival.
Saddoughi SA, Dunne B, Campo-Canaveral de la Cruz JL, Lemaitre P, Diaz Martinez JP, Martinu T, Donahoe L, de Perrot M, Pierre AF, Yasufuku K, Waddell TK, Chaparro C, Cypel M, Keshavjee S, Yeung JC. Saddoughi SA, et al. Among authors: chaparro c. J Thorac Cardiovasc Surg. 2024 Mar;167(3):861-868. doi: 10.1016/j.jtcvs.2023.07.043. Epub 2023 Aug 3. J Thorac Cardiovasc Surg. 2024. PMID: 37541572
OBJECTIVES: To determine the impact of older donor age (70+ years) on long-term survival and freedom from chronic lung allograft dysfunction in lung transplant (LTx) recipients. ...Univariable and multivariable Cox regression was used to describe differences in long-ter
OBJECTIVES: To determine the impact of older donor age (70+ years) on long-term survival and freedom from chronic lung allograft dysf …
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection.
Fallet M, Montagnani C, Petton B, Dantan L, de Lorgeril J, Comarmond S, Chaparro C, Toulza E, Boitard S, Escoubas JM, Vergnes A, Le Grand J, Bulla I, Gueguen Y, Vidal-Dupiol J, Grunau C, Mitta G, Cosseau C. Fallet M, et al. Among authors: chaparro c. Microbiome. 2022 Jun 4;10(1):85. doi: 10.1186/s40168-022-01280-5. Microbiome. 2022. PMID: 35659369 Free PMC article.
Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS. CONCLUSI …
Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic ma …
Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients.
Shah P, Lowery E, Chaparro C, Visner G, Hempstead SE, Abraham J, Bhakta Z, Carroll M, Christon L, Danziger-Isakov L, Diamond JM, Lease E, Leonard J, Litvin M, Poole R, Vlahos F, Werchan C, Murray MA, Tallarico E, Faro A, Pilewski JM, Hachem RR. Shah P, et al. Among authors: chaparro c. J Heart Lung Transplant. 2021 Jul;40(7):539-556. doi: 10.1016/j.healun.2021.04.011. Epub 2021 Apr 22. J Heart Lung Transplant. 2021. PMID: 34103223 Free article. Review.
Cystic fibrosis (CF) is the indication for transplantation in approximately 15% of recipients worldwide, and Cystic Fibrosis Lung Transplant Recipients (CFLTRs) have excellent long-term outcomes. Yet, CFLTRs have unique comorbidities that require specialized care. ...
Cystic fibrosis (CF) is the indication for transplantation in approximately 15% of recipients worldwide, and Cystic Fibrosis Lung Transplant …
A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas.
Lafont M, Vergnes A, Vidal-Dupiol J, de Lorgeril J, Gueguen Y, Haffner P, Petton B, Chaparro C, Barrachina C, Destoumieux-Garzon D, Mitta G, Gourbal B, Montagnani C. Lafont M, et al. Among authors: chaparro c. mBio. 2020 Mar 10;11(2):e02777-19. doi: 10.1128/mBio.02777-19. mBio. 2020. PMID: 32156821 Free PMC article.
This persistent antiviral alert state remains active over 4 months and supports antiviral protection in the long term. This acquired resistance mechanism reinforces the molecular foundations of the sustained response model of immune priming. ...
This persistent antiviral alert state remains active over 4 months and supports antiviral protection in the long term. This acquired …
Lung transplantation for cystic fibrosis.
Yeung JC, Machuca TN, Chaparro C, Cypel M, Stephenson AL, Solomon M, Saito T, Binnie M, Chow CW, Grasemann H, Pierre AF, Yasufuku K, de Perrot M, Donahoe LL, Tikkanen J, Martinu T, Waddell TK, Tullis E, Singer LG, Keshavjee S. Yeung JC, et al. Among authors: chaparro c. J Heart Lung Transplant. 2020 Jun;39(6):553-560. doi: 10.1016/j.healun.2020.02.010. Epub 2020 Feb 20. J Heart Lung Transplant. 2020. PMID: 32147452
CONCLUSIONS: Lung transplantation for CF provides excellent short- and long-term outcomes. These results strongly support lung transplantation as the standard of care for patients with CF having advanced lung disease....
CONCLUSIONS: Lung transplantation for CF provides excellent short- and long-term outcomes. These results strongly support lung transp …
Long-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion.
Divithotawela C, Cypel M, Martinu T, Singer LG, Binnie M, Chow CW, Chaparro C, Waddell TK, de Perrot M, Pierre A, Yasufuku K, Yeung JC, Donahoe L, Keshavjee S, Tikkanen JM. Divithotawela C, et al. Among authors: chaparro c. JAMA Surg. 2019 Dec 1;154(12):1143-1150. doi: 10.1001/jamasurg.2019.4079. JAMA Surg. 2019. PMID: 31596484 Free PMC article.
The lung donor pool may be increased by assessing and reconditioning high-risk extended criteria donor lungs with ex vivo lung perfusion (EVLP), with similar short-term outcomes. OBJECTIVE: To assess the long-term outcomes of transplant recipients of donor lungs tre …
The lung donor pool may be increased by assessing and reconditioning high-risk extended criteria donor lungs with ex vivo lung perfusion (EV …
Lack of association of Aspergillus colonization with the development of bronchiolitis obliterans syndrome in lung transplant recipients: An international cohort study.
Law N, Hamandi B, Fegbeutel C, Silveira FP, Verschuuren EA, Ussetti P, Chin-Hong PV, Sole A, Holmes-Liew CL, Billaud EM, Grossi PA, Manuel O, Levine DJ, Barbers RG, Hadjiliadis D, Younus M, Aram J, Chaparro C, Singer LG, Husain S. Law N, et al. Among authors: chaparro c. J Heart Lung Transplant. 2019 Sep;38(9):963-971. doi: 10.1016/j.healun.2019.06.007. Epub 2019 Jun 19. J Heart Lung Transplant. 2019. PMID: 31300191
BACKGROUND: Bronchiolitis obliterans syndrome (BOS) is a major limitation in the long-term survival of lung transplant recipients (LTRs). However, the risk factors in the development of BOS remain undetermined. ...
BACKGROUND: Bronchiolitis obliterans syndrome (BOS) is a major limitation in the long-term survival of lung transplant recipients (LT …
Comprehensive outcomes after lung retransplantation: A single-center review.
Halloran K, Aversa M, Tinckam K, Martinu T, Binnie M, Chaparro C, Chow CW, Waddell T, McRae K, Pierre A, de Perrot M, Yasufuku K, Cypel M, Keshavjee S, Singer LG. Halloran K, et al. Among authors: chaparro c. Clin Transplant. 2018 Jun;32(6):e13281. doi: 10.1111/ctr.13281. Epub 2018 Jun 3. Clin Transplant. 2018. PMID: 29754418 Clinical Trial.
CONCLUSIONS: Lung retransplantation is associated with a more complex postoperative course and lower peak lung function, but the long-term medical profile is similar to primary transplant. Lung retransplantation can be beneficial for carefully selected candidates with allo …
CONCLUSIONS: Lung retransplantation is associated with a more complex postoperative course and lower peak lung function, but the long-ter
Effects of a parental exposure to diuron on Pacific oyster spat methylome.
Rondon R, Grunau C, Fallet M, Charlemagne N, Sussarellu R, Chaparro C, Montagnani C, Mitta G, Bachère E, Akcha F, Cosseau C. Rondon R, et al. Among authors: chaparro c. Environ Epigenet. 2017 Apr 19;3(1):dvx004. doi: 10.1093/eep/dvx004. eCollection 2017 Jan. Environ Epigenet. 2017. PMID: 29492306 Free PMC article.
Chemical pollutants have been shown to affect immediate epigenetic information carriers of several aquatic species but the heritability of the chromatin marks and the consequences for long term adaptation remain open questions. In this work, we investigated the impact of t …
Chemical pollutants have been shown to affect immediate epigenetic information carriers of several aquatic species but the heritability of t …
28 results