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Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial.
Heerspink HJL, Radhakrishnan J, Alpers CE, Barratt J, Bieler S, Diva U, Inrig J, Komers R, Mercer A, Noronha IL, Rheault MN, Rote W, Rovin B, Trachtman H, Trimarchi H, Wong MG, Perkovic V; PROTECT Investigators. Heerspink HJL, et al. Lancet. 2023 May 13;401(10388):1584-1594. doi: 10.1016/S0140-6736(23)00569-X. Epub 2023 Apr 1. Lancet. 2023. PMID: 37015244 Clinical Trial.
Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term nephroprotective potential of sparsentan. FUNDING: Travere Therapeutics....
Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term …
Dynamic genome-wide gene expression and immune cell composition in the developing human placenta.
Suryawanshi H, Max K, Bogardus KA, Sopeyin A, Chang MS, Morozov P, Castano PM, Tuschl T, Williams Z. Suryawanshi H, et al. Among authors: chang ms. J Reprod Immunol. 2022 Jun;151:103624. doi: 10.1016/j.jri.2022.103624. Epub 2022 Apr 16. J Reprod Immunol. 2022. PMID: 35490534
To generate a reference gene expression map of first (T1), second (T2) and third (T3) trimester human placenta, and assess differences in transcriptome in maternal versus fetal side tissues sections of full-term placenta, we performed RNA-Seq analysis on 64 biopsy samples …
To generate a reference gene expression map of first (T1), second (T2) and third (T3) trimester human placenta, and assess differences in tr …
Does Interbody Support at L5-S1 Matter in Long Fusions to the Pelvis?: A 5-year Analysis.
Lara NJ, Chung AS, Lockwood D, Revella J, Crandall D, Chang MS. Lara NJ, et al. Among authors: chang ms. Spine (Phila Pa 1976). 2021 Aug 1;46(15):1014-1019. doi: 10.1097/BRS.0000000000003937. Spine (Phila Pa 1976). 2021. PMID: 33428359
Initial postop sagittal alignment was better in the IB group (PLF: 6.46 cm, IB: 2.48 cm, P = 0.007); however, this was not maintained over long-term follow-up. No significant differences in proximal junctional kyphosis (PLF: 7/23, IB: 9/65, P = 0.076). ...Both cohorts had …
Initial postop sagittal alignment was better in the IB group (PLF: 6.46 cm, IB: 2.48 cm, P = 0.007); however, this was not maintained over l …
Prognostic Value of the Alcoholic Hepatitis Histologic Score in Korean Patients with Biopsy-Proven Alcoholic Hepatitis.
Lee DH, Choi YI, Bae JM, Chang MS, Joo SK, Jung YJ, Lee KL, Kim BG, Kim W. Lee DH, et al. Among authors: chang ms. Gut Liver. 2020 Sep 15;14(5):636-643. doi: 10.5009/gnl19203. Gut Liver. 2020. PMID: 32457277 Free PMC article.
BACKGROUND/AIMS: The alcoholic hepatitis histologic score (AHHS) is a recently developed clinical model for predicting short-term mortality in Caucasian patients with alcoholic hepatitis (AH). ...Therefore, the AHHS might be a useful histological prognosticator for long- …
BACKGROUND/AIMS: The alcoholic hepatitis histologic score (AHHS) is a recently developed clinical model for predicting short-term mor …
Acute Lymphoblastic Leukemia in a Patient Treated with Letrozole and Palbociclib.
Park JH, Park H, Kim KH, Kim JS, Choi IS, Roh EY, Kim JE, Chang MS. Park JH, et al. Among authors: chang ms. J Breast Cancer. 2020 Feb;23(1):100-106. doi: 10.4048/jbc.2020.23.e1. J Breast Cancer. 2020. PMID: 32140274 Free PMC article.
Here, for the first time, we present a case of acute lymphoblastic leukemia that was diagnosed in a patient undergoing treatment with letrozole and palbociclib for metastatic breast cancer. This case emphasizes the need for long term follow up of patients treated with palb …
Here, for the first time, we present a case of acute lymphoblastic leukemia that was diagnosed in a patient undergoing treatment with letroz …
Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling.
Fan JJ, Hsu WH, Lee KH, Chen KC, Lin CW, Lee YA, Ko TP, Lee LT, Lee MT, Chang MS, Cheng CH. Fan JJ, et al. Among authors: chang ms. Antioxidants (Basel). 2019 Nov 15;8(11):557. doi: 10.3390/antiox8110557. Antioxidants (Basel). 2019. PMID: 31731716 Free PMC article.
Especially in dietary flavonoids, they have provided convenience and consistence of intake for long-term prevention of tumor formation. Previous reports suggested that S100 calcium-binding protein A7 (S100A7) might activate epithelial-mesenchymal transition (EMT) signaling …
Especially in dietary flavonoids, they have provided convenience and consistence of intake for long-term prevention of tumor formatio …
90-day Readmission in Elective Primary Lumbar Spine Surgery in the Inpatient Setting: A Nationwide Readmissions Database Sample Analysis.
Rubel NC, Chung AS, Wong M, Lara NJ, Makovicka JL, Arvind V, Chang MS, Cho SK. Rubel NC, et al. Among authors: chang ms. Spine (Phila Pa 1976). 2019 Jul 15;44(14):E857-E864. doi: 10.1097/BRS.0000000000002995. Spine (Phila Pa 1976). 2019. PMID: 30817732
SUMMARY OF BACKGROUND DATA: As bundled-payment models for the reimbursement of surgical services become more popular in spine, the focus is shifting toward long-term patient outcomes in the context of 90-day episodes of care. ...
SUMMARY OF BACKGROUND DATA: As bundled-payment models for the reimbursement of surgical services become more popular in spine, the focus is …
Antiviral therapy and the development of osteopenia/osteoporosis among Asians with chronic hepatitis B.
Wei MT, Le AK, Chang MS, Hsu H, Nguyen P, Zhang JQ, Wong C, Wong C, Cheung R, Nguyen MH. Wei MT, et al. Among authors: chang ms. J Med Virol. 2019 Jul;91(7):1288-1294. doi: 10.1002/jmv.25433. Epub 2019 Feb 27. J Med Virol. 2019. PMID: 30776311
However, further study with longer follow-up is needed as an anti-HBV therapy, which is often lifelong or long-term and the development of osteopenia/osteoporosis can be a slow process....
However, further study with longer follow-up is needed as an anti-HBV therapy, which is often lifelong or long-term and the developme …
Ultimate Clinical Outcomes of Appendiceal Mucinous Neoplasm of Uncertain Malignant Potential.
Shin R, Chai YJ, Park JW, Chang MS, Bae JM, Kim MJ, Park BK, Park KJ, Jeong SY. Shin R, et al. Among authors: chang ms. Ann Surg Oncol. 2017 Apr;24(4):974-982. doi: 10.1245/s10434-016-5657-6. Epub 2016 Nov 7. Ann Surg Oncol. 2017. PMID: 27822629
BACKGROUND: The clinical outcome of appendiceal mucinous neoplasm (AMN) is not well understood. This study aimed to compare the long-term outcome for the uncertain malignant potential (UMP) subtype of AMNs with those of the mucinous adenoma (MA) and mucinous adenocarcinoma …
BACKGROUND: The clinical outcome of appendiceal mucinous neoplasm (AMN) is not well understood. This study aimed to compare the long-term …
Improvement of cardiac function by short-term enzyme replacement therapy in a murine model of cardiomyopathy associated with Hunter syndrome evaluated by serial echocardiography with speckle tracking 2-D strain analysis.
Lee SC, Lee J, Jin DK, Kim JS, Jeon ES, Kwun YH, Chang MS, Ko AR, Yook YJ, Sohn YB. Lee SC, et al. Among authors: chang ms. Mol Genet Metab. 2014 Jul;112(3):218-23. doi: 10.1016/j.ymgme.2014.04.005. Epub 2014 Apr 30. Mol Genet Metab. 2014. PMID: 24836711
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