A decline in Wnt3a signaling is necessary for mesenchymal stem cells to proceed to replicative senescence.
Jeoung JY, Nam HY, Kwak J, Jin HJ, Lee HJ, Lee BW, Baek JH, Eom JS, Chang EJ, Shin DM, Choi SJ, Kim SW.
Jeoung JY, et al. Among authors: chang ej.
Stem Cells Dev. 2015 Apr 15;24(8):973-82. doi: 10.1089/scd.2014.0273. Epub 2015 Jan 8.
Stem Cells Dev. 2015.
PMID: 25437011
Free PMC article.
These results suggest that Wnt3a signaling might be a predominant factor that could be used to overcome senescence in long-term cultured MSCs by directly intervening in the proliferative capacity and MSC senescence. ...
These results suggest that Wnt3a signaling might be a predominant factor that could be used to overcome senescence in long-term cultu …