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Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand.
Yao M, Watanabe M, Sun S, Tokodai K, Cerami A, Brines M, Östenson CG, Ericzon BG, Lundgren T, Kumagai-Braesch M. Yao M, et al. Among authors: cerami a. Transplantation. 2020 Oct;104(10):2048-2058. doi: 10.1097/TP.0000000000003284. Transplantation. 2020. PMID: 32345869
Combination treatment with cibinetide and low-dose tacrolimus significantly improved long-term graft survival following allogeneic PITx. In vitro experiments indicated that cibinetide lowered bone-marrow-derived-immature-dendritic cell maturation and subsequently reduced a …
Combination treatment with cibinetide and low-dose tacrolimus significantly improved long-term graft survival following allogeneic PI …
Targeting the innate repair receptor to treat neuropathy.
Dahan A, Brines M, Niesters M, Cerami A, van Velzen M. Dahan A, et al. Among authors: cerami a. Pain Rep. 2016 Aug 9;1(1):e566. doi: 10.1097/PR9.0000000000000566. eCollection 2016 Jul. Pain Rep. 2016. PMID: 29392190 Free PMC article.
After sciatic nerve injury, ARA290 produced a rapid and long-term relief of mechanical and cold allodynia in normal mice, but not in animals with a beta-common receptor knockout phenotype. ...These experimental and clinical studies show that ARA290 effectively reprograms a …
After sciatic nerve injury, ARA290 produced a rapid and long-term relief of mechanical and cold allodynia in normal mice, but not in …
Chronic administration of small nonerythropoietic peptide sequence of erythropoietin effectively ameliorates the progression of postmyocardial infarction-dilated cardiomyopathy.
Ahmet I, Tae HJ, Brines M, Cerami A, Lakatta EG, Talan MI. Ahmet I, et al. Among authors: cerami a. J Pharmacol Exp Ther. 2013 Jun;345(3):446-56. doi: 10.1124/jpet.113.202945. Epub 2013 Apr 12. J Pharmacol Exp Ther. 2013. PMID: 23584743 Free PMC article.
The cardioprotective properties of erythropoietin (EPO) in preclinical studies are well documented, but erythropoietic and prothrombotic properties of EPO preclude its use in chronic heart failure (CHF). We tested the effect of long-term treatment with a small peptide sequ …
The cardioprotective properties of erythropoietin (EPO) in preclinical studies are well documented, but erythropoietic and prothrombotic pro …
Alternative erythropoietin-mediated signaling prevents secondary microvascular thrombosis and inflammation within cutaneous burns.
Bohr S, Patel SJ, Shen K, Vitalo AG, Brines M, Cerami A, Berthiaume F, Yarmush ML. Bohr S, et al. Among authors: cerami a. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3513-8. doi: 10.1073/pnas.1214099110. Epub 2013 Feb 11. Proc Natl Acad Sci U S A. 2013. PMID: 23401545 Free PMC article.
Furthermore, ARA290 mitigated the innate inflammatory response, most notably tumor necrosis factor-alpha-mediated signaling. These findings correlated with long-term recovery of initially injured yet viable tissue components. ...
Furthermore, ARA290 mitigated the innate inflammatory response, most notably tumor necrosis factor-alpha-mediated signaling. These findings …
ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain: an experimental study in rats and beta-common receptor knockout mice.
Swartjes M, Morariu A, Niesters M, Brines M, Cerami A, Aarts L, Dahan A. Swartjes M, et al. Among authors: cerami a. Anesthesiology. 2011 Nov;115(5):1084-92. doi: 10.1097/ALN.0b013e31822fcefd. Anesthesiology. 2011. PMID: 21873879 Free article.

RESULTS: In rats, irrespective of treatment paradigm, ARA290 produced effective, long-term (as long as 15 weeks) relief of tactile and cold allodynia (P < 0.001 vs. vehicle-treated animals). ...In contrast, in betacR mice no effect of ARA290 was observed. CONCLUSIONS: A

…
RESULTS: In rats, irrespective of treatment paradigm, ARA290 produced effective, long-term (as long as 15 weeks) relief of tactile an …
Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives.
Villa P, van Beek J, Larsen AK, Gerwien J, Christensen S, Cerami A, Brines M, Leist M, Ghezzi P, Torup L. Villa P, et al. Among authors: cerami a. J Cereb Blood Flow Metab. 2007 Mar;27(3):552-63. doi: 10.1038/sj.jcbfm.9600370. Epub 2006 Jul 12. J Cereb Blood Flow Metab. 2007. PMID: 16835629
Nevertheless, similarly to EPO, CEPO promotes neuroprotection on the histologic level in short-term stroke models. In the present study, we investigated whether CEPO and other nonerythropoietic EPO analogs could enhance functional recovery and promote long-term hist …
Nevertheless, similarly to EPO, CEPO promotes neuroprotection on the histologic level in short-term stroke models. In the present stu …
Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair.
Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A. Bucala R, et al. Among authors: cerami a. Mol Med. 1994 Nov;1(1):71-81. Mol Med. 1994. PMID: 8790603 Free PMC article.
Fibroblasts present in areas of tissue injury generally have been regarded to arise by recruitment from surrounding connective tissue; however this may not be the only source of these cells. MATERIALS AND METHODS: Long-term culture of adherent, human, and murine leukocyte …
Fibroblasts present in areas of tissue injury generally have been regarded to arise by recruitment from surrounding connective tissue; howev …
Comparative analysis of DNA mutations in lacI transgenic mice with age.
Lee AT, DeSimone C, Cerami A, Bucala R. Lee AT, et al. Among authors: cerami a. FASEB J. 1994 May;8(8):545-50. doi: 10.1096/fasebj.8.8.8181674. FASEB J. 1994. PMID: 8181674
Mutations of the lacI gene are easily detected by the derepression of beta-galactosidase resulting in blue plaques in the presence of X-gal. Originally developed as a short-term in vivo mutagenesis assay to screen genotoxic agents, we have used this system to measure natur …
Mutations of the lacI gene are easily detected by the derepression of beta-galactosidase resulting in blue plaques in the presence of X-gal. …
Hemoglobin-AGE: a circulating marker of advanced glycosylation.
Makita Z, Vlassara H, Rayfield E, Cartwright K, Friedman E, Rodby R, Cerami A, Bucala R. Makita Z, et al. Among authors: cerami a. Science. 1992 Oct 23;258(5082):651-3. doi: 10.1126/science.1411574. Science. 1992. PMID: 1411574
In a group of diabetic patients treated with the advanced glycosylation inhibitor aminoguanidine, Hb-AGE levels decreased significantly over a 1-month period. Hemoglobin-AGE measurements may provide an index of long-term tissue modification by AGEs and prove useful in asse …
In a group of diabetic patients treated with the advanced glycosylation inhibitor aminoguanidine, Hb-AGE levels decreased significantly over …
30 results