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Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma.
Mendez KM, Begum S, Tiwari A, Sharma R, Chen Q, Kelly RS, Prince N, Huang M, Kachroo P, Chu SH, Chen Y, Lee-Sarwar K, Broadhurst DI, Reinke SN, Gerszten R, Clish C, Avila L, Celedón JC, Wheelock CE, Weiss ST, McGeachie M, Lasky-Su JA. Mendez KM, et al. Among authors: celedon jc. EBioMedicine. 2024 Apr;102:105025. doi: 10.1016/j.ebiom.2024.105025. Epub 2024 Mar 7. EBioMedicine. 2024. PMID: 38458111 Free PMC article.
BACKGROUND: Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there is a growing body of metabolomic studies on asthma status and other phenotypes, there are no prospective studies of the relationship between …
BACKGROUND: Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there i …
Cluster Analysis of World Trade Center Related Lower Airway Diseases.
de la Hoz RE, Jeon Y, Doucette JT, Reeves AP, San José Estépar R, Celedón JC. de la Hoz RE, et al. Among authors: celedon jc. J Occup Environ Med. 2024 Feb 1;66(2):179-184. doi: 10.1097/JOM.0000000000003023. Epub 2023 Nov 29. J Occup Environ Med. 2024. PMID: 38305727
Conclusions: Cluster analysis confirms low FVC and COPD/pre-COPD as distinctive chronic lower airway disease phenotypes on long-term surveillance of the WTC workers....
Conclusions: Cluster analysis confirms low FVC and COPD/pre-COPD as distinctive chronic lower airway disease phenotypes on long-term …
A novel piwi-interacting RNA associates with type 2-high asthma phenotypes.
Li J, Hong X, Jiang M, Kho AT, Tiwari A, Wang AL, Chase RP, Celedón JC, Weiss ST, McGeachie MJ, Tantisira KG. Li J, et al. Among authors: celedon jc. J Allergy Clin Immunol. 2024 Mar;153(3):695-704. doi: 10.1016/j.jaci.2023.10.032. Epub 2023 Dec 4. J Allergy Clin Immunol. 2024. PMID: 38056635
Linear regression was used for the association analysis of piRNAs and peripheral blood eosinophil count, total serum IgE level, and long-term asthma exacerbation in children with asthma. Mediation analysis was performed to investigate the effect direction. ...All 22 signif …
Linear regression was used for the association analysis of piRNAs and peripheral blood eosinophil count, total serum IgE level, and long- …
Intrauterine Smoke Exposure, microRNA Expression during Human Lung Development, and Childhood Asthma.
Rosenberg L, Liu C, Sharma R, Wood C, Vyhlidal CA, Gaedigk R, Kho AT, Ziniti JP, Celedón JC, Tantisira KG, Weiss ST, McGeachie MJ, Kechris K, Sharma S. Rosenberg L, et al. Among authors: celedon jc. Int J Mol Sci. 2023 Apr 23;24(9):7727. doi: 10.3390/ijms24097727. Int J Mol Sci. 2023. PMID: 37175432 Free PMC article.
We also considered the above model with an additional sex-by-IUS interaction term, allowing IUS effects to differ by male and female samples. ...
We also considered the above model with an additional sex-by-IUS interaction term, allowing IUS effects to differ by male and female …
Maternal Depressive Symptoms, Lung Function, and Severe Asthma Exacerbations in Puerto Rican Children.
Stevens EL, Han YY, Rosser F, Forno E, Acosta-Pérez E, Miller GE, Canino G, Celedón JC. Stevens EL, et al. Among authors: celedon jc. J Allergy Clin Immunol Pract. 2021 Mar;9(3):1319-1326.e3. doi: 10.1016/j.jaip.2020.10.023. Epub 2020 Oct 28. J Allergy Clin Immunol Pract. 2021. PMID: 33127521 Free PMC article.
BACKGROUND: Maternal depression has been linked to health care use for asthma in cross-sectional or short-term follow-up studies of school-aged children. OBJECTIVE: To examine whether increased or persistent maternal depressive symptoms over approximately 5 years are assoc …
BACKGROUND: Maternal depression has been linked to health care use for asthma in cross-sectional or short-term follow-up studies of s …
A proposal for the addressing the needs of the pediatric pulmonary work force.
Gaston B, Laguna TA, Noah TL, Hagood J, Voynow J, Ferkol T, Hershenson M, Boyne K, Delecaris A, Ross K, Gozal D, Celedón JC, Abman SH, Moore P, Davis S, Cornfield DN, Murphy T. Gaston B, et al. Among authors: celedon jc. Pediatr Pulmonol. 2020 Aug;55(8):1859-1867. doi: 10.1002/ppul.24856. Epub 2020 Jun 12. Pediatr Pulmonol. 2020. PMID: 32531116 Free PMC article.
To address these issues and optimize pediatric pulmonary training, a group of faculty from various institutions met in 2019 and proposed specific, long-term solutions to the emerging problems in the field. Input on these ideas was then solicited more broadly from faculty w …
To address these issues and optimize pediatric pulmonary training, a group of faculty from various institutions met in 2019 and proposed spe …
Annual SO2 exposure, asthma, atopy, and lung function in Puerto Rican children.
Rosser F, Forno E, Kurland KS, Han YY, Mair C, Acosta-Pérez E, Canino G, Celedón JC. Rosser F, et al. Among authors: celedon jc. Pediatr Pulmonol. 2020 Feb;55(2):330-337. doi: 10.1002/ppul.24595. Epub 2019 Dec 5. Pediatr Pulmonol. 2020. PMID: 31805225 Free PMC article.
BACKGROUND: Long-term effects of sulfur dioxide (SO(2) ) exposure on children, a vulnerable population, are largely unknown. ...CONCLUSIONS: Among Puerto Rican children in Puerto Rico, long-term SO(2) exposure is linked to asthma and atopy. In these children, long- …
BACKGROUND: Long-term effects of sulfur dioxide (SO(2) ) exposure on children, a vulnerable population, are largely unknown. ...CONCL …
Epigenomics and Transcriptomics in the Prediction and Diagnosis of Childhood Asthma: Are We There Yet?
Forno E, Celedón JC. Forno E, et al. Among authors: celedon jc. Front Pediatr. 2019 Apr 2;7:115. doi: 10.3389/fped.2019.00115. eCollection 2019. Front Pediatr. 2019. PMID: 31001502 Free PMC article. Review.
Epigenetic regulation is highly tissue-specific, and can induce both short- and long-term changes in gene expression. Such changes can start in utero, can vary throughout the life span, and in some instances can be passed on from one generation to another. ...
Epigenetic regulation is highly tissue-specific, and can induce both short- and long-term changes in gene expression. Such changes ca …
Moving toward true inclusion of racial/ethnic minorities in federally funded studies. A key step for achieving respiratory health equality in the United States.
Burchard EG, Oh SS, Foreman MG, Celedón JC. Burchard EG, et al. Among authors: celedon jc. Am J Respir Crit Care Med. 2015 Mar 1;191(5):514-21. doi: 10.1164/rccm.201410-1944PP. Am J Respir Crit Care Med. 2015. PMID: 25584658 Free PMC article.
This problem could be remedied by implementing short-, medium-, and long-term strategies, such as creating incentives to conduct minority research, ensuring fair review of grant applications focusing on minorities, developing the careers of minority scientists, and facilit …
This problem could be remedied by implementing short-, medium-, and long-term strategies, such as creating incentives to conduct mino …
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