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Age-Dependent Chronic Lung Injury and Pulmonary Fibrosis following Single Exposure to Hydrochloric Acid.
Colunga Biancatelli RML, Solopov P, Dimitropoulou C, Catravas JD. Colunga Biancatelli RML, et al. Among authors: catravas jd. Int J Mol Sci. 2021 Aug 17;22(16):8833. doi: 10.3390/ijms22168833. Int J Mol Sci. 2021. PMID: 34445540 Free PMC article.
Young mice developed increased Newtonian resistance (Rn) and lower PV loops, while adults showed a higher respiratory system resistance and elastance. This data indicate that young p24 mice can suffer long-term complications from a single exposure to HCl, and can develop c …
Young mice developed increased Newtonian resistance (Rn) and lower PV loops, while adults showed a higher respiratory system resistance and …
Development of chronic lung injury and pulmonary fibrosis in mice following acute exposure to nitrogen mustard.
Solopov P, Marinova M, Dimitropoulou C, Colunga Biancatelli RML, Catravas JD. Solopov P, et al. Among authors: catravas jd. Inhal Toxicol. 2020 Mar;32(4):141-154. doi: 10.1080/08958378.2020.1757791. Epub 2020 May 3. Inhal Toxicol. 2020. PMID: 32362214
Exposure to nitrogen mustards (NM), their more water-soluble analogs, is associated with respiratory, dermatological, neurological, and systemic symptoms whose severity depends on dose and length of contact. Long-term effects of acute inhalation have been related to the de …
Exposure to nitrogen mustards (NM), their more water-soluble analogs, is associated with respiratory, dermatological, neurological, and syst …
Acute exposure of mice to hydrochloric acid leads to the development of chronic lung injury and pulmonary fibrosis.
Marinova M, Solopov P, Dimitropoulou C, Colunga Biancatelli RML, Catravas JD. Marinova M, et al. Among authors: catravas jd. Inhal Toxicol. 2019 Mar;31(4):147-160. doi: 10.1080/08958378.2019.1624895. Epub 2019 Jun 23. Inhal Toxicol. 2019. PMID: 31232121
Objective: Accidental exposure to hydrochloric acid (HCl) is associated with acute lung injury in humans, development of long-term chronic airway obstruction, and fibrosis. However, the mechanisms responsible for the progression to pulmonary fibrosis remain unclear. ...
Objective: Accidental exposure to hydrochloric acid (HCl) is associated with acute lung injury in humans, development of long-term ch …
Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production.
Chen F, Pandey D, Chadli A, Catravas JD, Chen T, Fulton DJ. Chen F, et al. Among authors: catravas jd. Antioxid Redox Signal. 2011 Jun;14(11):2107-19. doi: 10.1089/ars.2010.3669. Epub 2011 Mar 13. Antioxid Redox Signal. 2011. PMID: 21194376 Free PMC article.
Coimmunoprecipitation and bioluminescence resonance energy transfer studies suggest that the C-terminus of Nox5 binds to Hsp90. Long-term Hsp90 inhibition reduced Nox5 expression and provides further evidence that Nox5 is an Hsp90 client protein. ...Hydrogen peroxide produ …
Coimmunoprecipitation and bioluminescence resonance energy transfer studies suggest that the C-terminus of Nox5 binds to Hsp90. Long-term …
Effects of hsp90 binding inhibitors on sGC-mediated vascular relaxation.
Yetik-Anacak G, Xia T, Dimitropoulou C, Venema RC, Catravas JD. Yetik-Anacak G, et al. Among authors: catravas jd. Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H260-8. doi: 10.1152/ajpheart.01027.2005. Epub 2006 Feb 17. Am J Physiol Heart Circ Physiol. 2006. PMID: 16489110 Free article.
Indomethacin or the antioxidant tiron did not affect the inhibition of ACh-induced relaxations by GA. Long-term (15 h) exposure to RA inhibited all NO donor-induced relaxations; however, GA inhibited SNN-induced relaxation only. ...
Indomethacin or the antioxidant tiron did not affect the inhibition of ACh-induced relaxations by GA. Long-term (15 h) exposure to RA …
Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding.
Papapetropoulos A, Zhou Z, Gerassimou C, Yetik G, Venema RC, Roussos C, Sessa WC, Catravas JD. Papapetropoulos A, et al. Among authors: catravas jd. Mol Pharmacol. 2005 Oct;68(4):1133-41. doi: 10.1124/mol.105.012682. Epub 2005 Jul 15. Mol Pharmacol. 2005. PMID: 16024662
The physiological importance of the hsp90/sGC interaction was investigated by treating rat smooth muscle cells with the hsp90 inhibitors radicicol and geldanamycin (GA) and determining both sGC activity and protein levels. Long-term (24 or 48 h) inhibition of hsp90 resulte …
The physiological importance of the hsp90/sGC interaction was investigated by treating rat smooth muscle cells with the hsp90 inhibitors rad …
Monocyte-induced downregulation of nitric oxide synthase in cultured aortic endothelial cells.
Marczin N, Antonov A, Papapetropoulos A, Munn DH, Virmani R, Kolodgie FD, Gerrity R, Catravas JD. Marczin N, et al. Among authors: catravas jd. Arterioscler Thromb Vasc Biol. 1996 Sep;16(9):1095-103. doi: 10.1161/01.atv.16.9.1095. Arterioscler Thromb Vasc Biol. 1996. PMID: 8792762
Since endothelium-dependent vasodilation is altered in atherosclerosis and enhanced monocyte/endothelial interactions are implicated in early atherosclerosis, we evaluated the effects of monocytes on the endothelial nitric oxide (NO) pathway by estimating release of biologically …
Since endothelium-dependent vasodilation is altered in atherosclerosis and enhanced monocyte/endothelial interactions are implicated in earl …
Methylene blue inhibits nitrovasodilator- and endothelium-derived relaxing factor-induced cyclic GMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion.
Marczin N, Ryan US, Catravas JD. Marczin N, et al. Among authors: catravas jd. J Pharmacol Exp Ther. 1992 Oct;263(1):170-9. J Pharmacol Exp Ther. 1992. PMID: 1328604
Control or MB-pretreated RPASM were stimulated with sodium nitroprusside (SNP), nitrosothiols or endothelium-derived relaxing factor (EDRF) released basally from bovine pulmonary arterial endothelial cells, in short-term co-cultures. The putative EDRF, S-nitroso-L-cysteine …
Control or MB-pretreated RPASM were stimulated with sodium nitroprusside (SNP), nitrosothiols or endothelium-derived relaxing factor (EDRF) …
Endothelial cGMP does not regulate basal release of endothelium-derived relaxing factor in culture.
Marczin N, Ryan US, Catravas JD. Marczin N, et al. Among authors: catravas jd. Am J Physiol. 1992 Jul;263(1 Pt 1):L113-21. doi: 10.1152/ajplung.1992.263.1.L113. Am J Physiol. 1992. PMID: 1379001
Endothelial cell-induced increases in smooth muscle cGMP levels were inhibited by competitive inhibitors of endothelial nitric oxide synthesis, NG-monomethyl-L-arginine and N omega-nitro-L-arginine, in both long-term cocultures and short-term bioassay. Such treatmen …
Endothelial cell-induced increases in smooth muscle cGMP levels were inhibited by competitive inhibitors of endothelial nitric oxide synthes …
13 results