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Topical application of a G-Quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration.
Leaderer D, Cashman SM, Kumar-Singh R. Leaderer D, et al. Among authors: cashman sm. Exp Eye Res. 2015 Nov;140:171-178. doi: 10.1016/j.exer.2015.09.005. Epub 2015 Sep 12. Exp Eye Res. 2015. PMID: 26368850 Free PMC article.
However, intravitreal injections are associated with complications and long-term inhibition of VEGF leads to macular atrophy. Thus, there is currently an unmet need for the development of therapies for CNV that target molecules other than VEGF. ...
However, intravitreal injections are associated with complications and long-term inhibition of VEGF leads to macular atrophy. Thus, t …
Inhibition of choroidal neovascularization by adenovirus-mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD.
Cashman SM, Bowman L, Christofferson J, Kumar-Singh R. Cashman SM, et al. Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3496-504. doi: 10.1167/iovs.05-1610. Invest Ophthalmol Vis Sci. 2006. PMID: 16877421
Current approaches to attenuate VEGF or its receptors, including the use of small interfering (si)RNA, show significant promise, but still have limited efficacy and require repeat administrations, using procedures associated with multiple complications. The goal of this study was …
Current approaches to attenuate VEGF or its receptors, including the use of small interfering (si)RNA, show significant promise, but still h …