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Cyclosporin A-loaded dissolving microneedles for dermatitis therapy: Development, characterisation and efficacy in a delayed-type hypersensitivity in vivo model.
Martínez-Navarrete M, Guillot AJ, Lobita MC, Recio MC, Giner R, Aparicio-Blanco J, Montesinos MC, Santos HA, Melero A. Martínez-Navarrete M, et al. Drug Deliv Transl Res. 2024 Mar 12. doi: 10.1007/s13346-024-01542-9. Online ahead of print. Drug Deliv Transl Res. 2024. PMID: 38472726
Several drugs can be used for treating inflammatory skin pathologies like dermatitis and psoriasis. However, for the management of chronic and long-term cases, topical administration is preferred over oral delivery since it prevents certain issues due to systemic si …
Several drugs can be used for treating inflammatory skin pathologies like dermatitis and psoriasis. However, for the management of chronic a …
Fetal High-Risk APOL1 Genotype Increases Risk for Small for Gestational Age in Term Infants Affected by Preeclampsia.
Azhibekov T, Durodoye R, Miller AK, Simpson CL, Davis RL, Williams SM, Bruggeman LA. Azhibekov T, et al. Neonatology. 2023;120(4):532-536. doi: 10.1159/000529850. Epub 2023 Apr 14. Neonatology. 2023. PMID: 37062283 Free PMC article.
RESULTS: Term preeclampsia cases with high-risk APOL1 genotypes were more likely to be small for gestational age compared to APOL1 low-risk term cases (odds ratio [OR] 2.8) and APOL1 high-risk controls (OR 5.5). ...
RESULTS: Term preeclampsia cases with high-risk APOL1 genotypes were more likely to be small for gestational age compared to APOL1 low-risk …
Metabolic patterns in brain 18F-fluorodeoxyglucose PET relate to aetiology in paediatric dystonia.
Tsagkaris S, Yau EKC, McClelland V, Papandreou A, Siddiqui A, Lumsden DE, Kaminska M, Guedj E, Hammers A, Lin JP. Tsagkaris S, et al. Brain. 2023 Jun 1;146(6):2512-2523. doi: 10.1093/brain/awac439. Brain. 2023. PMID: 36445406 Free PMC article.
Scans without gross anatomical abnormality (e.g. large cysts, significant ventriculomegaly; n = 240) were analysed with Statistical Parametric Mapping (SPM12). ...The combination of frontal and parietal lobe hypermetabolism was uniquely found in CP-term cases …
Scans without gross anatomical abnormality (e.g. large cysts, significant ventriculomegaly; n = 240) were analysed with Statistical P …
Reduced Placental CD24 in Preterm Preeclampsia Is an Indicator for a Failure of Immune Tolerance.
Sammar M, Siwetz M, Meiri H, Sharabi-Nov A, Altevogt P, Huppertz B. Sammar M, et al. Int J Mol Sci. 2021 Jul 28;22(15):8045. doi: 10.3390/ijms22158045. Int J Mol Sci. 2021. PMID: 34360811 Free PMC article.
Here, we explored the expression of CD24 in PE placenta in preterm and term cases. METHODS: Placentas were derived from first and early second trimester social terminations (N = 43), and third trimester normal term delivery (N = 67), preterm PE (N …
Here, we explored the expression of CD24 in PE placenta in preterm and term cases. METHODS: Placentas were derived from first …
Parent-of-origin-specific allelic expression in the human placenta is limited to established imprinted loci and it is stably maintained across pregnancy.
Pilvar D, Reiman M, Pilvar A, Laan M. Pilvar D, et al. Clin Epigenetics. 2019 Jun 26;11(1):94. doi: 10.1186/s13148-019-0692-3. Clin Epigenetics. 2019. PMID: 31242935 Free PMC article.
The study utilized RNA-Seq-based transcriptome and genotyping data from 54 parental-placental samples representing the three trimesters of gestation, and term cases of preeclampsia, gestational diabetes, and fetal growth disturbances. RESULTS: Almost half of the tar …
The study utilized RNA-Seq-based transcriptome and genotyping data from 54 parental-placental samples representing the three trimesters of g …
Cisatracurium- and rocuronium-associated residual neuromuscular dysfunction under intraoperative neuromuscular monitoring and postoperative neostigmine reversal: a single-blind randomized trial.
Feltracco P, Tonetti T, Barbieri S, Frigo AC, Ori C. Feltracco P, et al. J Clin Anesth. 2016 Dec;35:198-204. doi: 10.1016/j.jclinane.2016.07.031. Epub 2016 Sep 7. J Clin Anesth. 2016. PMID: 27871520 Clinical Trial.
INTERVENTIONS: Patients were randomized to receive either cisatracurium (n=60) or rocuronium (n=60) at the time of intubation and during surgery. ...CONCLUSION: Careful conduction, monitoring, and subsequent reversal of neuromuscular block may allow for obtaining co …
INTERVENTIONS: Patients were randomized to receive either cisatracurium (n=60) or rocuronium (n=60) at the time of intubation …
Laterality defects in the national birth defects prevention study (1998-2007): birth prevalence and descriptive epidemiology.
Lin AE, Krikov S, Riehle-Colarusso T, Frías JL, Belmont J, Anderka M, Geva T, Getz KD, Botto LD; National Birth Defects Prevention Study. Lin AE, et al. Am J Med Genet A. 2014 Oct;164A(10):2581-91. doi: 10.1002/ajmg.a.36695. Epub 2014 Aug 6. Am J Med Genet A. 2014. PMID: 25099286 Free PMC article.
Laterality defects were more common among preterm cases compared to term cases, and in children born to mothers who were non-white or younger than 20 years compared to white mothers or those age 25-29 years. ...
Laterality defects were more common among preterm cases compared to term cases, and in children born to mothers who were non-w …
A proposed new clinical staging system for patients with mucosal leishmaniasis.
Lessa HA, Lessa MM, Guimarães LH, Lima CM, Arruda S, Machado PR, Carvalho EM. Lessa HA, et al. Trans R Soc Trop Med Hyg. 2012 Jun;106(6):376-81. doi: 10.1016/j.trstmh.2012.03.007. Epub 2012 May 11. Trans R Soc Trop Med Hyg. 2012. PMID: 22578516 Free PMC article.
The different degrees of evolution of mucosal disease, from the initial stage to the more severe long-term cases, enabled ML to be graded into five stages. Stage I is characterised by nodular lesions of the mucosa without ulceration. ...
The different degrees of evolution of mucosal disease, from the initial stage to the more severe long-term cases, enabled ML t …
Apoptosis and Bcl-2 protein expression in human placenta over the course of normal pregnancy.
Soni S, Rath G, Prasad CP, Salhan S, Saxena S, Jain AK. Soni S, et al. Anat Histol Embryol. 2010 Oct;39(5):426-31. doi: 10.1111/j.1439-0264.2010.01012.x. Anat Histol Embryol. 2010. PMID: 20608924

Bcl-2 protein was found immunolocalized in the cytoplasm of syncytiotrophoblast. Apoptosis index was significantly reduced in term cases as compared with first trimester (P < 0.002) and mid-trimester placentae (P = 0.01). On the contrary, Bcl-2 expression was sig

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Bcl-2 protein was found immunolocalized in the cytoplasm of syncytiotrophoblast. Apoptosis index was significantly reduced in term …
A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injury.
Chen XH, Johnson VE, Uryu K, Trojanowski JQ, Smith DH. Chen XH, et al. Brain Pathol. 2009 Apr;19(2):214-23. doi: 10.1111/j.1750-3639.2008.00176.x. Epub 2008 May 19. Brain Pathol. 2009. PMID: 18492093 Free PMC article.
However, in marked contrast to the plaque pathology noted in short-term cases post TBI, virtually no Abeta plaques were found in long-term survivors. ...
However, in marked contrast to the plaque pathology noted in short-term cases post TBI, virtually no Abeta plaques were found …
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