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The disease-specific clinical trial network for primary ciliary dyskinesia: PCD-CTN.
Raidt J, Maitre B, Pennekamp P, Altenburg J, Anagnostopoulou P, Armengot M, Bloemsma LD, Boon M, Borrelli M, Brinkmann F, Carr SB, Carroll MP, Castillo-Corullón S, Coste A, Cutrera R, Dehlink E, Destouches DMS, Di Cicco ME, Dixon L, Emiralioglu N, Erdem Eralp E, Haarman EG, Hogg C, Karadag B, Kobbernagel HE, Lorent N, Mall MA, Marthin JK, Martinu V, Narayanan M, Ozcelik U, Peckham D, Pifferi M, Pohunek P, Polverino E, Range S, Ringshausen FC, Robson E, Roehmel J, Rovira-Amigo S, Santamaria F, Schlegtendal A, Szépfalusi Z, Tempels P, Thouvenin G, Ullmann N, Walker WT, Wetzke M, Yiallouros P, Omran H, Nielsen KG. Raidt J, et al. Among authors: carroll mp. ERJ Open Res. 2022 Aug 15;8(3):00139-2022. doi: 10.1183/23120541.00139-2022. eCollection 2022 Jul. ERJ Open Res. 2022. PMID: 35983540 Free PMC article.
Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilience.
Stressmann FA, Rogers GB, van der Gast CJ, Marsh P, Vermeer LS, Carroll MP, Hoffman L, Daniels TW, Patel N, Forbes B, Bruce KD. Stressmann FA, et al. Among authors: carroll mp. Thorax. 2012 Oct;67(10):867-73. doi: 10.1136/thoraxjnl-2011-200932. Epub 2012 Jun 15. Thorax. 2012. PMID: 22707521
Modelling the bacterial communities associated with cystic fibrosis lung infections.
Spasenovski T, Carroll MP, Lilley AK, Payne MS, Bruce KD. Spasenovski T, et al. Among authors: carroll mp. Eur J Clin Microbiol Infect Dis. 2010 Mar;29(3):319-28. doi: 10.1007/s10096-009-0861-y. Epub 2010 Jan 23. Eur J Clin Microbiol Infect Dis. 2010. PMID: 20099020
The overall aim of this study was to develop biofilm models in vitro that resembled the bacterial species composition of CF sputa. Here, this was a step towards a longer term goal of forming multiple bacterial biofilm models in vitro that would serve, in turn, as better as …
The overall aim of this study was to develop biofilm models in vitro that resembled the bacterial species composition of CF sputa. Here, thi …
Inhaled heparin in cystic fibrosis.
Serisier DJ, Shute JK, Hockey PM, Higgins B, Conway J, Carroll MP. Serisier DJ, et al. Among authors: carroll mp. Eur Respir J. 2006 Feb;27(2):354-8. doi: 10.1183/09031936.06.00069005. Eur Respir J. 2006. PMID: 16452592 Free article. Clinical Trial.
Unfractionated heparin may be mucolytic and has demonstrated a number of anti-inflammatory properties; however, further safety data are needed in these subjects who are at risk of airway bleeding. The current study aimed to assess the medium-term safety and tolerability of …
Unfractionated heparin may be mucolytic and has demonstrated a number of anti-inflammatory properties; however, further safety data are need …
Is there a case for n-3 fatty acid supplementation in cystic fibrosis?
Cawood AL, Carroll MP, Wootton SA, Calder PC. Cawood AL, et al. Among authors: carroll mp. Curr Opin Clin Nutr Metab Care. 2005 Mar;8(2):153-9. doi: 10.1097/00075197-200503000-00008. Curr Opin Clin Nutr Metab Care. 2005. PMID: 15716793 Review.
SUMMARY: The restoration of abnormal fatty acid profiles may be beneficial in cystic fibrosis, but this approach has not been evaluated in studies with a suitable design to permit firm conclusions to be drawn. There is a need for a long-term randomized controlled study to …
SUMMARY: The restoration of abnormal fatty acid profiles may be beneficial in cystic fibrosis, but this approach has not been evaluated in s …
Endobronchial allergen challenge.
Frew AJ, Carroll MP, Gratziou C, Krug N. Frew AJ, et al. Among authors: carroll mp. Eur Respir J Suppl. 1998 Mar;26:33S-35S. Eur Respir J Suppl. 1998. PMID: 9585878 Review.
Despite the local nature of the challenge, LEAC often has a significant effect on FEV1 and may cause short-term destabilization of asthma. In common with other bronchoscopic methods used to study human asthma, samples obtained by LEAC show a considerable degree of variabil …
Despite the local nature of the challenge, LEAC often has a significant effect on FEV1 and may cause short-term destabilization of as …
BMT for severe aplastic anemia using cyclosporine.
May WS, Sensenbrenner LL, Burns WH, Ambinder R, Carroll MP, Griffin CA, Jones RJ, Miller CB, Mellits ED, Vogelsang GB, et al. May WS, et al. Among authors: carroll mp. Bone Marrow Transplant. 1993 Jun;11(6):459-64. Bone Marrow Transplant. 1993. PMID: 8334426
Between 1984 and 1991 24 patients with severe aplastic anemia (SAA) were transplanted with HLA identical sibling donor BM. The overall long-term survival was 79 +/- 8%. The average age was 21 years (range 4-53 years) and the median pre-transplant disease duration was 35 da …
Between 1984 and 1991 24 patients with severe aplastic anemia (SAA) were transplanted with HLA identical sibling donor BM. The overall long- …
Domiciliary nocturnal nasal intermittent positive pressure ventilation in hypercapnic respiratory failure due to chronic obstructive lung disease: effects on sleep and quality of life.
Elliott MW, Simonds AK, Carroll MP, Wedzicha JA, Branthwaite MA. Elliott MW, et al. Among authors: carroll mp. Thorax. 1992 May;47(5):342-8. doi: 10.1136/thx.47.5.342. Thorax. 1992. PMID: 1609376 Free PMC article.
Its future place in management can be established only by formal comparison with long term oxygen therapy....
Its future place in management can be established only by formal comparison with long term oxygen therapy....