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The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function.
Cantero Mdel R, Velázquez IF, Streets AJ, Ong AC, Cantiello HF. Cantero Mdel R, et al. Among authors: cantiello hf. J Biol Chem. 2015 Sep 25;290(39):23888-96. doi: 10.1074/jbc.M115.661082. Epub 2015 Aug 12. J Biol Chem. 2015. PMID: 26269590 Free PMC article.
However, the role of PC2 phosphorylation in channel function is still poorly defined. Here we reconstituted apical membranes of term human syncytiotrophoblast (hST), containing endogenous PC2 (PC2hst), and in vitro translated channel protein (PC2iv). ...
However, the role of PC2 phosphorylation in channel function is still poorly defined. Here we reconstituted apical membranes of term …
Calcium transport and local pool regulate polycystin-2 (TRPP2) function in human syncytiotrophoblast.
Cantero Mdel R, Cantiello HF. Cantero Mdel R, et al. Among authors: cantiello hf. Biophys J. 2013 Jul 16;105(2):365-75. doi: 10.1016/j.bpj.2013.05.058. Biophys J. 2013. PMID: 23870258 Free PMC article.
Polycystin-2 (PC2, TRPP2) is a Ca(2+)-permeable, nonselective cation channel implicated in Ca(2+) transport and epithelial cell signaling. Although PC2 may contribute to Ca(2+) transport in human term placenta, the regulatory mechanisms associated with Ca(2+) handling in t …
Polycystin-2 (PC2, TRPP2) is a Ca(2+)-permeable, nonselective cation channel implicated in Ca(2+) transport and epithelial cell signaling. A …
Morphological and electrical properties of human trophoblast choriocarcinoma, BeWo cells.
Ramos AJ, Cantero MR, Zhang P, Raychowdhury MK, Green A, MacPhee D, Cantiello HF. Ramos AJ, et al. Among authors: cantiello hf. Placenta. 2008 Jun;29(6):492-502. doi: 10.1016/j.placenta.2008.02.013. Epub 2008 Apr 16. Placenta. 2008. PMID: 18420268
The presence of the cation channel protein, polycystin-2 (PC2), a TRP-type cation channel, associated with placental ion transport in term human syncytiotrophoblast, co-localised with acetylated tubulin in midbodies, but was found non-functional under any conditions. ...
The presence of the cation channel protein, polycystin-2 (PC2), a TRP-type cation channel, associated with placental ion transport in ter …
Reactive oxygen species inhibit polycystin-2 (TRPP2) cation channel activity in term human syncytiotrophoblast.
Montalbetti N, Cantero MR, Dalghi MG, Cantiello HF. Montalbetti N, et al. Among authors: cantiello hf. Placenta. 2008 Jun;29(6):510-8. doi: 10.1016/j.placenta.2008.02.015. Epub 2008 Apr 15. Placenta. 2008. PMID: 18417208
Pregnancy is often associated with oxidative stress (OS) and lower antioxidant defences, which are both implicated in the pathophysiology of preeclampsia, free radical-induced birth defects, and abortions, as well as gestational diabetes mellitus (GDM), where products of l …
Pregnancy is often associated with oxidative stress (OS) and lower antioxidant defences, which are both implicated in the pathophysiology of …
Polycystin-2 cation channel function in the human syncytiotrophoblast is regulated by microtubular structures.
Montalbetti N, Li Q, Wu Y, Chen XZ, Cantiello HF. Montalbetti N, et al. Among authors: cantiello hf. J Physiol. 2007 Mar 15;579(Pt 3):717-28. doi: 10.1113/jphysiol.2006.125583. Epub 2007 Jan 4. J Physiol. 2007. PMID: 17204494 Free PMC article.
Polycystin-2 (PC2), encoded by PKD2, which is one of the genes whose mutations cause polycystic kidney disease, is abundantly produced in the apical domain of the syncytiotrophoblast (hST) of term human placenta. PC2, a TRP-type (TRPP2) non-selective cation channel, is pre …
Polycystin-2 (PC2), encoded by PKD2, which is one of the genes whose mutations cause polycystic kidney disease, is abundantly produced in th …
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel.
González-Perrett S, Kim K, Ibarra C, Damiano AE, Zotta E, Batelli M, Harris PC, Reisin IL, Arnaout MA, Cantiello HF. González-Perrett S, et al. Among authors: cantiello hf. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1182-7. doi: 10.1073/pnas.98.3.1182. Proc Natl Acad Sci U S A. 2001. PMID: 11252306 Free PMC article.
Defects in polycystin-2, a ubiquitous transmembrane glycoprotein of unknown function, is a major cause of autosomal dominant polycystic kidney disease (ADPKD), whose manifestation entails the development of fluid-filled cysts in target organs. Here, we demonstrate that polycystin …
Defects in polycystin-2, a ubiquitous transmembrane glycoprotein of unknown function, is a major cause of autosomal dominant polycystic kidn …