BCL6 promotes a stem-like CD8+ T cell program in cancer via antagonizing BLIMP1.
Sun Q, Cai D, Liu D, Zhao X, Li R, Xu W, Xie B, Gou M, Wei K, Li Y, Huang J, Chi X, Wei P, Hao J, Guo X, Pan B, Fu Y, Ni L, Dong C.
Sun Q, et al. Among authors: cai d.
Sci Immunol. 2023 Oct 27;8(88):eadh1306. doi: 10.1126/sciimmunol.adh1306. Epub 2023 Oct 20.
Sci Immunol. 2023.
PMID: 37862431
Here, we found that BCL6 inhibits tumor-specific T(term) cell generation from T(prog) cell downstream of TCF1. We show that Bcl6 deficiency reduced the persistence of T(prog) cells, without affecting their generation, thus abrogating long-term tumor control. ...Mech …
Here, we found that BCL6 inhibits tumor-specific T(term) cell generation from T(prog) cell downstream of TCF1. We show that Bcl6 defi …