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Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis.
Chalmers JD, Smith MP, McHugh BJ, Doherty C, Govan JR, Hill AT. Chalmers JD, et al. Am J Respir Crit Care Med. 2012 Oct 1;186(7):657-65. doi: 10.1164/rccm.201203-0487OC. Epub 2012 Jun 28. Am J Respir Crit Care Med. 2012. PMID: 22744718 Clinical Trial.
METHODS: The relationship between bacterial load and airway and systemic inflammation was investigated in 385 stable patients, 15 stable patients treated with intravenous antibiotics, and 34 patients with an exacerbation of bronchiectasis treated with intravenous antibiotics. Lon …
METHODS: The relationship between bacterial load and airway and systemic inflammation was investigated in 385 stable patients, 15 stable pat …
Evaluating success of therapy for bronchiectasis: what end points to use?
Smith MP, Hill AT. Smith MP, et al. Clin Chest Med. 2012 Jun;33(2):329-49. doi: 10.1016/j.ccm.2012.03.001. Epub 2012 Apr 20. Clin Chest Med. 2012. PMID: 22640849 Review.
Long-term treatment goals of bronchiectasis frequently include limiting the bacterial burden and inflammatory insult in the airways with the aim of improving symptoms, reducing exacerbation frequency and severity, and improving health-related quality-of-life. ...This artic …
Long-term treatment goals of bronchiectasis frequently include limiting the bacterial burden and inflammatory insult in the airways w …
A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis.
Murray MP, Govan JR, Doherty CJ, Simpson AJ, Wilkinson TS, Chalmers JD, Greening AP, Haslett C, Hill AT. Murray MP, et al. Am J Respir Crit Care Med. 2011 Feb 15;183(4):491-9. doi: 10.1164/rccm.201005-0756OC. Epub 2010 Sep 24. Am J Respir Crit Care Med. 2011. PMID: 20870753 Clinical Trial.
RATIONALE: Bronchiectasis is a chronic debilitating disease with few evidence-based long-term treatments. OBJECTIVES: A randomized controlled trial assessing the efficacy of nebulized gentamicin therapy over 1 year in patients with non-cystic fibrosis bronchiectasis. ...At …
RATIONALE: Bronchiectasis is a chronic debilitating disease with few evidence-based long-term treatments. OBJECTIVES: A randomized co …