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Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication.
Biochem J. 1998 May 15;332 ( Pt 1)(Pt 1):43-50. doi: 10.1042/bj3320043.
Biochem J. 1998.
PMID: 9576849
Free PMC article.
When treated with sub-lethal concentrations of H2O2, pre-senescent human fibroblasts enter long-term growth arrest resembling replicative senescence. To understand the molecular basis for the H2O2-induced growth arrest, we determined the cell cycle distribution, levels of …
When treated with sub-lethal concentrations of H2O2, pre-senescent human fibroblasts enter long-term growth arrest resembling replica …
The free radical theory of aging matures.
Beckman KB, Ames BN.
Beckman KB, et al.
Physiol Rev. 1998 Apr;78(2):547-81. doi: 10.1152/physrev.1998.78.2.547.
Physiol Rev. 1998.
PMID: 9562038
Free article.
Review.
During the past decade, several lines of evidence have convinced a number of scientists that oxidants play an important role in aging. (For the sake of simplicity, we use the term oxidant to refer to all "reactive oxygen species," including O2-., H2O2, and .OH, even though …
During the past decade, several lines of evidence have convinced a number of scientists that oxidants play an important role in aging. (For …
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