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Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication.
Chen QM, Bartholomew JC, Campisi J, Acosta M, Reagan JD, Ames BN. Chen QM, et al. Biochem J. 1998 May 15;332 ( Pt 1)(Pt 1):43-50. doi: 10.1042/bj3320043. Biochem J. 1998. PMID: 9576849 Free PMC article.
When treated with sub-lethal concentrations of H2O2, pre-senescent human fibroblasts enter long-term growth arrest resembling replicative senescence. To understand the molecular basis for the H2O2-induced growth arrest, we determined the cell cycle distribution, levels of …
When treated with sub-lethal concentrations of H2O2, pre-senescent human fibroblasts enter long-term growth arrest resembling replica …
The free radical theory of aging matures.
Beckman KB, Ames BN. Beckman KB, et al. Physiol Rev. 1998 Apr;78(2):547-81. doi: 10.1152/physrev.1998.78.2.547. Physiol Rev. 1998. PMID: 9562038 Free article. Review.
During the past decade, several lines of evidence have convinced a number of scientists that oxidants play an important role in aging. (For the sake of simplicity, we use the term oxidant to refer to all "reactive oxygen species," including O2-., H2O2, and .OH, even though …
During the past decade, several lines of evidence have convinced a number of scientists that oxidants play an important role in aging. (For …