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Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections.
PLoS Pathog. 2015 Sep 11;11(9):e1005146. doi: 10.1371/journal.ppat.1005146. eCollection 2015 Sep.
PLoS Pathog. 2015.
PMID: 26360709
Free PMC article.
Previously, the natural SIVcpz infection of one chimpanzee, and the experimental infection of six chimpanzees was reported, with limited follow-up. Here, we present a long-term study of these seven animals, with a retrospective re-examination of the early stages of infecti …
Previously, the natural SIVcpz infection of one chimpanzee, and the experimental infection of six chimpanzees was reported, with limited fol …
GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees.
Lanford RE, Guerra B, Chavez D, Giavedoni L, Hodara VL, Brasky KM, Fosdick A, Frey CR, Zheng J, Wolfgang G, Halcomb RL, Tumas DB.
Lanford RE, et al.
Gastroenterology. 2013 Jun;144(7):1508-17, 1517.e1-10. doi: 10.1053/j.gastro.2013.02.003. Epub 2013 Feb 13.
Gastroenterology. 2013.
PMID: 23415804
Free PMC article.
Clinical pathology parameters were monitored to determine the safety and tolerability of GS-9620. RESULTS: Short-term oral administration of GS-9620 provided long-term suppression of serum and liver HBV DNA. ...
Clinical pathology parameters were monitored to determine the safety and tolerability of GS-9620. RESULTS: Short-term oral administra …
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Maintenance or emergence of chronic phase secondary cytotoxic T lymphocyte responses after loss of acute phase immunodominant responses does not protect SIV-infected rhesus macaques from disease progression.
Keckler MS, Hodara VL, Parodi LM, Giavedoni LD.
Keckler MS, et al.
J Biomed Biotechnol. 2010;2010:279391. doi: 10.1155/2010/279391. Epub 2010 May 25.
J Biomed Biotechnol. 2010.
PMID: 20589067
Free PMC article.
We observed the evolution of epitopes targeted by CTLs in a group of macaques that included long-term nonprogressing (LTNP), slowly progressing (SP), normally progressing (NP), and rapidly progressing (RP) animals. ...
We observed the evolution of epitopes targeted by CTLs in a group of macaques that included long-term nonprogressing (LTNP), slowly p …
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Thermostable llama single domain antibodies for detection of botulinum A neurotoxin complex.
Goldman ER, Anderson GP, Conway J, Sherwood LJ, Fech M, Vo B, Liu JL, Hayhurst A.
Goldman ER, et al.
Anal Chem. 2008 Nov 15;80(22):8583-91. doi: 10.1021/ac8014774. Epub 2008 Oct 24.
Anal Chem. 2008.
PMID: 18947189
Free PMC article.
The unique properties of these sdAb may provide advantages for many diagnostic applications where long-term storage and in-line monitoring require very rugged yet highly specific recognition elements....
The unique properties of these sdAb may provide advantages for many diagnostic applications where long-term storage and in-line monit …
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