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Social determinants of respiratory health from birth: still of concern in the 21st century?
Bush A, Byrnes CA, Chan KC, Chang AB, Ferreira JC, Holden KA, Lovinsky-Desir S, Redding G, Singh V, Sinha IP, Zar HJ. Bush A, et al. Among authors: byrnes ca. Eur Respir Rev. 2024 Apr 10;33(172):230222. doi: 10.1183/16000617.0222-2023. Print 2024 Apr 30. Eur Respir Rev. 2024. PMID: 38599675 Free PMC article. Review.
Respiratory symptoms are ubiquitous in children and, even though they may be the harbinger of poor long-term outcomes, are often trivialised. Adverse exposures pre-conception, antenatally and in early childhood have lifetime impacts on respiratory health. ...
Respiratory symptoms are ubiquitous in children and, even though they may be the harbinger of poor long-term outcomes, are often triv …
Thoracic Society of Australia and New Zealand (TSANZ) position statement on chronic suppurative lung disease and bronchiectasis in children, adolescents and adults in Australia and New Zealand.
Chang AB, Bell SC, Byrnes CA, Dawkins P, Holland AE, Kennedy E, King PT, Laird P, Mooney S, Morgan L, Parsons M, Poot B, Toombs M, Torzillo PJ, Grimwood K. Chang AB, et al. Among authors: byrnes ca. Respirology. 2023 Apr;28(4):339-349. doi: 10.1111/resp.14479. Epub 2023 Mar 2. Respirology. 2023. PMID: 36863703 Free PMC article.
Eradicate Pseudomonas aeruginosa when newly detected in lower airway cultures. Individualize therapy for long-term antibiotics, inhaled corticosteroids, bronchodilators and mucoactive agents. ...
Eradicate Pseudomonas aeruginosa when newly detected in lower airway cultures. Individualize therapy for long-term antibiotics, inhal …
Long-term Azithromycin in Children With Bronchiectasis Unrelated to Cystic Fibrosis: Treatment Effects Over Time.
Vicendese D, Yerkovich S, Grimwood K, Valery PC, Byrnes CA, Morris PS, Dharmage SC, Chang AB. Vicendese D, et al. Among authors: byrnes ca. Chest. 2023 Jan;163(1):52-63. doi: 10.1016/j.chest.2022.08.2216. Epub 2022 Aug 27. Chest. 2023. PMID: 36030839 Clinical Trial.
BACKGROUND: Following evidence from randomized controlled trials, patients with bronchiectasis unrelated to cystic fibrosis receive long-term azithromycin to reduce acute respiratory exacerbations. However, the period when azithromycin is effective and which patients are l …
BACKGROUND: Following evidence from randomized controlled trials, patients with bronchiectasis unrelated to cystic fibrosis receive long- …
Extended Versus Standard Antibiotic Course Duration in Children <5 Years of Age Hospitalized With Community-acquired Pneumonia in High-risk Settings: Four-week Outcomes of a Multicenter, Double-blind, Parallel, Superiority Randomized Controlled Trial.
McCallum GB, Fong SM, Grimwood K, Nathan AM, Byrnes CA, Ooi MH, Nachiappan N, Saari N, Morris PS, Yeo TW, Ware RS, Elogius BW, Oguoma VM, Yerkovich ST, de Bruyne J, Lawrence KA, Lee B, Upham JW, Torzillo PJ, Chang AB. McCallum GB, et al. Among authors: byrnes ca. Pediatr Infect Dis J. 2022 Jul 1;41(7):549-555. doi: 10.1097/INF.0000000000003558. Epub 2022 Jun 7. Pediatr Infect Dis J. 2022. PMID: 35476706 Clinical Trial.
Additional research will identify if an extended course provides longer-term benefits....
Additional research will identify if an extended course provides longer-term benefits....
A decade on: Follow-up findings of indigenous children with bronchiectasis.
McCallum GB, Singleton RJ, Redding GJ, Grimwood K, Byrnes CA, Valery PC, Mobberley C, Oguoma VM, Eg KP, Morris PS, Chang AB. McCallum GB, et al. Among authors: byrnes ca. Pediatr Pulmonol. 2020 Apr;55(4):975-985. doi: 10.1002/ppul.24696. Epub 2020 Feb 25. Pediatr Pulmonol. 2020. PMID: 32096916
OBJECTIVE: The sole prospective longitudinal study of children with either chronic suppurative lung disease (CSLD) or bronchiectasis published in the current era was limited to a single center. We sought to extend this study by evaluating the longer-term clinical and lung …
OBJECTIVE: The sole prospective longitudinal study of children with either chronic suppurative lung disease (CSLD) or bronchiectasis publish …
HOspitalised Pneumonia Extended (HOPE) Study to reduce the long-term effects of childhood pneumonia: protocol for a multicentre, double-blind, parallel, superiority randomised controlled trial.
Chang AB, Fong SM, Yeo TW, Ware RS, McCallum GB, Nathan AM, Ooi MH, de Bruyne J, Byrnes CA, Lee B, Nachiappan N, Saari N, Torzillo P, Smith-Vaughan H, Morris PS, Upham JW, Grimwood K. Chang AB, et al. Among authors: byrnes ca. BMJ Open. 2019 Apr 24;9(4):e026411. doi: 10.1136/bmjopen-2018-026411. BMJ Open. 2019. PMID: 31023759 Free PMC article. Clinical Trial.
INTRODUCTION: Early childhood pneumonia is a common problem globally with long-term complications that include bronchiectasis and chronic obstructive pulmonary disease. ...Outcomes from randomised controlled trials (RCTs) on paediatric pneumonia have focused on short-te …
INTRODUCTION: Early childhood pneumonia is a common problem globally with long-term complications that include bronchiectasis and chr …
Bronchiectasis: Treatment decisions for pulmonary exacerbations and their prevention.
Bell SC, Elborn JS, Byrnes CA. Bell SC, et al. Among authors: byrnes ca. Respirology. 2018 Nov;23(11):1006-1022. doi: 10.1111/resp.13398. Epub 2018 Sep 11. Respirology. 2018. PMID: 30207018 Free article. Review.
This review considers the evidence for defining and treating pulmonary exacerbations, the approaches for eradication of newly identified airway pathogens and the methods to prevent exacerbations through long-term treatments from a pragmatic practice-based perspective. Area …
This review considers the evidence for defining and treating pulmonary exacerbations, the approaches for eradication of newly identified air …
Nasopharyngeal carriage and macrolide resistance in Indigenous children with bronchiectasis randomized to long-term azithromycin or placebo.
Hare KM, Grimwood K, Chang AB, Chatfield MD, Valery PC, Leach AJ, Smith-Vaughan HC, Morris PS, Byrnes CA, Torzillo PJ, Cheng AC. Hare KM, et al. Among authors: byrnes ca. Eur J Clin Microbiol Infect Dis. 2015 Nov;34(11):2275-85. doi: 10.1007/s10096-015-2480-0. Epub 2015 Sep 12. Eur J Clin Microbiol Infect Dis. 2015. PMID: 26363637 Clinical Trial.
Although long-term azithromycin decreases exacerbation frequency in bronchiectasis, increased macrolide resistance is concerning. ...
Although long-term azithromycin decreases exacerbation frequency in bronchiectasis, increased macrolide resistance is concerning. ...
Long-term azithromycin for Indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease (Bronchiectasis Intervention Study): a multicentre, double-blind, randomised controlled trial.
Valery PC, Morris PS, Byrnes CA, Grimwood K, Torzillo PJ, Bauert PA, Masters IB, Diaz A, McCallum GB, Mobberley C, Tjhung I, Hare KM, Ware RS, Chang AB. Valery PC, et al. Among authors: byrnes ca. Lancet Respir Med. 2013 Oct;1(8):610-620. doi: 10.1016/S2213-2600(13)70185-1. Epub 2013 Sep 17. Lancet Respir Med. 2013. PMID: 24461664 Clinical Trial.
BACKGROUND: Indigenous children in high-income countries have a heavy burden of bronchiectasis unrelated to cystic fibrosis. We aimed to establish whether long-term azithromycin reduced pulmonary exacerbations in Indigenous children with non-cystic-fibrosis bronchiectasis …
BACKGROUND: Indigenous children in high-income countries have a heavy burden of bronchiectasis unrelated to cystic fibrosis. We aimed to est …
Heated humidification improves clinical outcomes, compared to a heat and moisture exchanger in children with tracheostomies.
McNamara DG, Asher MI, Rubin BK, Stewart A, Byrnes CA. McNamara DG, et al. Among authors: byrnes ca. Respir Care. 2014 Jan;59(1):46-53. doi: 10.4187/respcare.02214. Epub 2013 Jun 13. Respir Care. 2014. PMID: 23764867 Free article. Clinical Trial.
Subjects were assessed for clinical events, clinical examination findings, airway cytokine levels, and airway secretion viscoelasticity. RESULTS: For the short-term study, 15 children were recruited; for the long-term study, 14 children were recruited. Children usin …
Subjects were assessed for clinical events, clinical examination findings, airway cytokine levels, and airway secretion viscoelasticity. RES …
14 results