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Role of T cells in inflammation caused by adenovirus vectors in the brain.
Byrnes AP, Wood MJ, Charlton HM. Byrnes AP, et al. Gene Ther. 1996 Jul;3(7):644-51. Gene Ther. 1996. PMID: 8818653
In many organs, E1-deleted human adenovirus vectors trigger antiviral T cell responses which limit the duration of vector-encoded gene expression. When injected into the brain, however, long-term expression is possible in spite of the ensuing inflammatory response. ...We c …
In many organs, E1-deleted human adenovirus vectors trigger antiviral T cell responses which limit the duration of vector-encoded gene expre …