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Body composition and weight changes after ivacaftor treatment in adults with cystic fibrosis carrying the G551 D cystic fibrosis transmembrane conductance regulator mutation: A double-blind, placebo-controlled, randomized, crossover study with open-label extension.
King SJ, Tierney AC, Edgeworth D, Keating D, Williams E, Kotsimbos T, Button BM, Wilson JW. King SJ, et al. Among authors: button bm. Nutrition. 2021 May;85:111124. doi: 10.1016/j.nut.2020.111124. Epub 2021 Feb 8. Nutrition. 2021. PMID: 33571868 Clinical Trial.
OBJECTIVES: In patients with cystic fibrosis (CF) who carry the G551D mutation, treatment with ivacaftor improves lung function and weight; however, short- and long-term impacts on body composition have not been well studied. METHODS: Twenty adults with CF carrying the G55 …
OBJECTIVES: In patients with cystic fibrosis (CF) who carry the G551D mutation, treatment with ivacaftor improves lung function and weight; …
Effect of Upper Limb Rehabilitation Compared to No Upper Limb Rehabilitation in Lung Transplant Recipients: A Randomized Controlled Trial.
Fuller LM, El-Ansary D, Button BM, Corbett M, Snell G, Marasco S, Holland AE. Fuller LM, et al. Among authors: button bm. Arch Phys Med Rehabil. 2018 Jul;99(7):1257-1264.e2. doi: 10.1016/j.apmr.2017.09.115. Epub 2017 Oct 16. Arch Phys Med Rehabil. 2018. PMID: 29042172 Clinical Trial.
No serious adverse events were reported. CONCLUSIONS: UL rehabilitation results in short-term improvements in pain and muscle strength after LTx, but no longer-term effects were evident....
No serious adverse events were reported. CONCLUSIONS: UL rehabilitation results in short-term improvements in pain and muscle strengt …
Physical activity participation by adults with cystic fibrosis: An observational study.
Cox NS, Alison JA, Button BM, Wilson JW, Morton JM, Holland AE. Cox NS, et al. Among authors: button bm. Respirology. 2016 Apr;21(3):511-8. doi: 10.1111/resp.12719. Epub 2015 Dec 30. Respirology. 2016. PMID: 26715596
In adults with CF, objectively measured PA time and its relationship to long-term clinical outcomes of respiratory function and need for hospitalization are unknown. ...
In adults with CF, objectively measured PA time and its relationship to long-term clinical outcomes of respiratory function and need …
Optimising inhaled mannitol for cystic fibrosis in an adult population.
Flume PA, Aitken ML, Bilton D, Agent P, Charlton B, Forster E, Fox HG, Hebestreit H, Kolbe J, Zuckerman JB, Button BM. Flume PA, et al. Among authors: button bm. Breathe (Sheff). 2015 Mar;11(1):39-48. doi: 10.1183/20734735.021414. Breathe (Sheff). 2015. PMID: 26306102 Free PMC article. Review.
Inhalation of mannitol as a dry powder is thought to change the viscoelastic properties of airway secretions, increase the hydration of the airway surface liquid and contribute to increased mucociliary and cough clearance of retained secretions. In two large phase 3 studies [1, 2 …
Inhalation of mannitol as a dry powder is thought to change the viscoelastic properties of airway secretions, increase the hydration of the …
The long term effect of inhaled hypertonic saline 6% in non-cystic fibrosis bronchiectasis.
Nicolson CH, Stirling RG, Borg BM, Button BM, Wilson JW, Holland AE. Nicolson CH, et al. Among authors: button bm. Respir Med. 2012 May;106(5):661-7. doi: 10.1016/j.rmed.2011.12.021. Epub 2012 Feb 19. Respir Med. 2012. PMID: 22349069 Free article. Clinical Trial.
BACKGROUND AND AIMS: Inhalation of hypertonic saline (HTS) has short term positive effects on airways clearance in non-cystic fibrosis (CF) bronchiectasis, however its long term effects are unknown. ...
BACKGROUND AND AIMS: Inhalation of hypertonic saline (HTS) has short term positive effects on airways clearance in non-cystic fibrosi …
Desaturation during the 3-minute step test predicts impaired 12-month outcomes in adult patients with cystic fibrosis.
Holland AE, Rasekaba T, Wilson JW, Button BM. Holland AE, et al. Among authors: button bm. Respir Care. 2011 Aug;56(8):1137-42. doi: 10.4187/respcare.01016. Epub 2011 Apr 15. Respir Care. 2011. PMID: 21496365 Free article.
CONCLUSIONS: Desaturation during the 3-minute step test is associated with long-term pulmonary deterioration and more hospital days in adults with CF. ...
CONCLUSIONS: Desaturation during the 3-minute step test is associated with long-term pulmonary deterioration and more hospital days i …
Is there a role for airway clearance techniques in chronic obstructive pulmonary disease?
Holland AE, Button BM. Holland AE, et al. Among authors: button bm. Chron Respir Dis. 2006;3(2):83-91. doi: 10.1191/1479972306cd097rs. Chron Respir Dis. 2006. PMID: 16729766 Free article. Review.
Clinical trials of airway clearance techniques (ACTs) in COPD have shown mixed results with little evidence of long-term benefit. However many studies have failed to account for the heterogeneity of COPD lung disease, particularly with regard to the presence of bronchiecta …
Clinical trials of airway clearance techniques (ACTs) in COPD have shown mixed results with little evidence of long-term benefit. How …