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Ivermectin for COVID-19 in adults in the community (PRINCIPLE): An open, randomised, controlled, adaptive platform trial of short- and longer-term outcomes.
Hayward G, Yu LM, Little P, Gbinigie O, Shanyinde M, Harris V, Dorward J, Saville BR, Berry N, Evans PH, Thomas NPB, Patel MG, Richards D, Hecke OV, Detry MA, Saunders C, Fitzgerald M, Robinson J, Latimer-Bell C, Allen J, Ogburn E, Grabey J, de Lusignan S, Hobbs FR, Butler CC; PRINCIPLE Trial Collaborative Group. Hayward G, et al. Among authors: butler cc. J Infect. 2024 Apr;88(4):106130. doi: 10.1016/j.jinf.2024.106130. Epub 2024 Feb 29. J Infect. 2024. PMID: 38431155 Free PMC article. Clinical Trial.
BACKGROUND: The evidence for whether ivermectin impacts recovery, hospital admissions, and longer-term outcomes in COVID-19 is contested. The WHO recommends its use only in the context of clinical trials. ...INTERPRETATION: Ivermectin for COVID-19 is unlikely to provide cl …
BACKGROUND: The evidence for whether ivermectin impacts recovery, hospital admissions, and longer-term outcomes in COVID-19 is contes …
Diagnostic accuracy of a point-of-care urine tenofovir assay, and associations with HIV viraemia and drug resistance among people receiving dolutegravir and efavirenz-based antiretroviral therapy.
Dorward J, Lessells R, Govender K, Moodley P, Samsunder N, Sookrajh Y, Turner P, Butler CC, Hayward G, Gandhi M, Drain PK, Garrett N. Dorward J, et al. Among authors: butler cc. J Int AIDS Soc. 2023 Sep;26(9):e26172. doi: 10.1002/jia2.26172. J Int AIDS Soc. 2023. PMID: 37735860 Free PMC article.
Urine TFV results were associated with short (p<0.001) and medium-term (p = 0.036) self-reported adherence. Overall, 44/124 (35.5%) had viraemia, which was associated with undetectable TFV in those receiving efavirenz (OR 6.01, 1.27-39.0, p = 0.014) and dolutegravir (OR …
Urine TFV results were associated with short (p<0.001) and medium-term (p = 0.036) self-reported adherence. Overall, 44/124 (35.5% …
Gut microbiology of UK care home residents: a cross-sectional analysis from a randomised controlled trial.
Gillespie D, Wootton M, Ray R, Calder PC, Mandy Lau TM, Owen-Jones E, Lowe R, Davies L, Richards J, Hood K, Castro-Herrera V, Davies J, Francis NA, Hobbs FDR, Lown M, Moore M, Shepherd V, Butler CC. Gillespie D, et al. Among authors: butler cc. Clin Microbiol Infect. 2023 Aug 17:S1198-743X(23)00362-2. doi: 10.1016/j.cmi.2023.08.001. Online ahead of print. Clin Microbiol Infect. 2023. PMID: 37595801 Free article.
Formal recognition of host-generalist species of dinoflagellate (Cladocopium, Symbiodiniaceae) mutualistic with Indo-Pacific reef corals.
Butler CC, Turnham KE, Lewis AM, Nitschke MR, Warner ME, Kemp DW, Hoegh-Guldberg O, Fitt WK, van Oppen MJH, LaJeunesse TC. Butler CC, et al. J Phycol. 2023 Aug;59(4):698-711. doi: 10.1111/jpy.13340. Epub 2023 May 31. J Phycol. 2023. PMID: 37126002
Large-scale shifts in symbiont dominance could ensure reef coral persistence and productivity in the near term. Ultimately, these formal designations should advance scientific communication and generate informed research questions on the physiology and ecology of coral-din …
Large-scale shifts in symbiont dominance could ensure reef coral persistence and productivity in the near term. Ultimately, these for …
Experiences and concerns of health workers throughout the first year of the COVID-19 pandemic in the UK: A longitudinal qualitative interview study.
Borek AJ, Pilbeam C, Mableson H, Wanat M, Atkinson P, Sheard S, Martindale AM, Solomon T, Butler CC, Gobat N, Tonkin-Crine S. Borek AJ, et al. Among authors: butler cc. PLoS One. 2022 Mar 16;17(3):e0264906. doi: 10.1371/journal.pone.0264906. eCollection 2022. PLoS One. 2022. PMID: 35294450 Free PMC article.
RESULTS: We conducted 105 interviews with 14 participants and identified three phases corresponding with shifts in HWs' experiences and concerns. (1) Emergency and mobilisation phase (late winter-spring 2020), with significant rapid shifts in responsibilities, required skills, an …
RESULTS: We conducted 105 interviews with 14 participants and identified three phases corresponding with shifts in HWs' experiences and conc …
Patients' and clinicians' perspectives on the primary care consultations for acute respiratory infections during the first wave of the COVID-19 pandemic: an eight-country qualitative study in Europe.
Wanat M, Hoste ME, Gobat NH, Anastasaki M, Böhmer F, Chlabicz S, Colliers A, Farrell K, Hollerbach S, Karkana MN, Kinsman J, Lionis C, Marcinowicz L, Reinhardt K, Skoglund I, Sundvall PD, Vellinga A, Goossens H, Butler CC, van der Velden A, Anthierens S, Tonkin-Crine S. Wanat M, et al. Among authors: butler cc. BJGP Open. 2022 Aug 30;6(2):BJGPO.2021.0172. doi: 10.3399/BJGPO.2021.0172. Print 2022 Jun. BJGP Open. 2022. PMID: 35031559 Free PMC article.
CONCLUSION: Remote consultations for RTI symptoms may be acceptable long term if both groups are happy to use this format, but it is important that PCPs take time to address patients' concerns and provide safety-netting advice....
CONCLUSION: Remote consultations for RTI symptoms may be acceptable long term if both groups are happy to use this format, but it is …
Influenza and Respiratory Virus Surveillance, Vaccine Uptake, and Effectiveness at a Time of Cocirculating COVID-19: Protocol for the English Primary Care Sentinel System for 2020-2021.
de Lusignan S, Lopez Bernal J, Byford R, Amirthalingam G, Ferreira F, Akinyemi O, Andrews N, Campbell H, Dabrera G, Deeks A, Elliot AJ, Krajenbrink E, Liyanage H, McGagh D, Okusi C, Parimalanathan V, Ramsay M, Smith G, Tripathy M, Williams J, Victor W, Zambon M, Howsam G, Nicholson BD, Tzortziou Brown V, Butler CC, Joy M, Hobbs FDR. de Lusignan S, et al. Among authors: butler cc. JMIR Public Health Surveill. 2021 Feb 19;7(2):e24341. doi: 10.2196/24341. JMIR Public Health Surveill. 2021. PMID: 33605892 Free PMC article.
Third, approximately 300 practices will participate in the 2020-2021 virology and serology surveillance; this will include responsive surveillance and long-term follow-up of previous SARS-CoV-2 infections. Fourth, member practices will be able to recruit volunteer patients …
Third, approximately 300 practices will participate in the 2020-2021 virology and serology surveillance; this will include responsive survei …
The impact of the COVID-19 lockdown on HIV care in 65 South African primary care clinics: an interrupted time series analysis.
Dorward J, Khubone T, Gate K, Ngobese H, Sookrajh Y, Mkhize S, Jeewa A, Bottomley C, Lewis L, Baisley K, Butler CC, Gxagxisa N, Garrett N. Dorward J, et al. Among authors: butler cc. Lancet HIV. 2021 Mar;8(3):e158-e165. doi: 10.1016/S2352-3018(20)30359-3. Epub 2021 Feb 4. Lancet HIV. 2021. PMID: 33549166 Free PMC article.
We recorded a median of 41 926 HIV tests per month before lockdown (January, 2018, to March, 2020; IQR 37 838-51 069) and a median of 38 911 HIV tests per month after lockdown (April, 2020, to July, 2020; IQR 32 699-42 756). In the Poisson regression model, taking into account lo …
We recorded a median of 41 926 HIV tests per month before lockdown (January, 2018, to March, 2020; IQR 37 838-51 069) and a median of 38 911 …
C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT.
Francis NA, Gillespie D, White P, Bates J, Lowe R, Sewell B, Phillips R, Stanton H, Kirby N, Wootton M, Thomas-Jones E, Hood K, Llor C, Cals J, Melbye H, Naik G, Gal M, Fitzsimmons D, Alam MF, Riga E, Cochrane A, Butler CC. Francis NA, et al. Among authors: butler cc. Health Technol Assess. 2020 Mar;24(15):1-108. doi: 10.3310/hta24150. Health Technol Assess. 2020. PMID: 32202490 Free PMC article. Clinical Trial.
FUTURE WORK: Implementation studies that also build on our qualitative findings could help determine the effect of this intervention over the longer term. TRIAL REGISTRATION: Current Controlled Trials ISRCTN24346473. ...
FUTURE WORK: Implementation studies that also build on our qualitative findings could help determine the effect of this intervention over th …
Optimising trial designs to identify appropriate antibiotic treatment durations.
Pouwels KB, Yin M, Butler CC, Cooper BS, Wordsworth S, Walker AS, Robotham JV. Pouwels KB, et al. Among authors: butler cc. BMC Med. 2019 Jun 21;17(1):115. doi: 10.1186/s12916-019-1348-z. BMC Med. 2019. PMID: 31221165 Free PMC article. Clinical Trial.
The estimation of course length must consider the important trade-off between maximising short- and long-term efficacy and minimising antibiotic resistance and toxicity. ...
The estimation of course length must consider the important trade-off between maximising short- and long-term efficacy and minimising …
40 results