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A guideline on the molecular ecosystem regulating ferroptosis.
Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D. Dai E, et al. Among authors: bush ai. Nat Cell Biol. 2024 Feb 29. doi: 10.1038/s41556-024-01360-8. Online ahead of print. Nat Cell Biol. 2024. PMID: 38424270 Review.
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mech …
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest …
An Online, Person-Centered, Risk Factor Management Program to Prevent Cognitive Decline: Protocol for A Prospective Behavior-Modification Blinded Endpoint Randomized Controlled Trial.
Lim YY, Ayton D, Perin S, Lavale A, Yassi N, Buckley R, Barton C, Bruns L, Morello R, Pirotta S, Rosenich E, Rajaratnam SMW, Sinnott R, Brodtmann A, Bush AI, Maruff P, Churilov L, Barker A, Pase MP; BetterBrains Research Group. Lim YY, et al. Among authors: bush ai. J Alzheimers Dis. 2021;83(4):1603-1622. doi: 10.3233/JAD-210589. J Alzheimers Dis. 2021. PMID: 34420970 Clinical Trial.
By leveraging existing community services and using a risk factor management pathway that tailors the intervention to each participant, we maximize likelihood for engagement, long-term adherence, and for preserving cognitive function in at-risk individuals....
By leveraging existing community services and using a risk factor management pathway that tailors the intervention to each participant, we m …
Parkinsonism as a Third Wave of the COVID-19 Pandemic?
Beauchamp LC, Finkelstein DI, Bush AI, Evans AH, Barnham KJ. Beauchamp LC, et al. Among authors: bush ai. J Parkinsons Dis. 2020;10(4):1343-1353. doi: 10.3233/JPD-202211. J Parkinsons Dis. 2020. PMID: 32986683 Free PMC article.
As it is possible to identify premorbid harbingers of Parkinson's disease, we propose long-term screening of SARS-CoV-2 cases post-recovery for these expressions of neurodegenerative disease. An accurate understanding of the incidence of neurological complications in COVID …
As it is possible to identify premorbid harbingers of Parkinson's disease, we propose long-term screening of SARS-CoV-2 cases post-re …
Adrenergic β receptor activation reduces amyloid β1-42-mediated intracellular Zn2+ toxicity in dentate granule cells followed by rescuing impairment of dentate gyrus LTP.
Tamano H, Ishikawa Y, Shioya A, Itoh R, Oneta N, Shimaya R, Egawa M, Adlard PA, Bush AI, Takeda A. Tamano H, et al. Among authors: bush ai. Neurotoxicology. 2020 Jul;79:177-183. doi: 10.1016/j.neuro.2020.06.001. Epub 2020 Jun 5. Neurotoxicology. 2020. PMID: 32512026
Adrenergic beta receptor activation prevents human soluble amyloid beta (Abeta)-induced impairment of long-term potentiation (LTP) in slices. On the basis of the evidence that human Abeta(1-42)-induced impairment of LTP is due to Abeta(1-42)-mediated Zn(2+) toxicity, we po …
Adrenergic beta receptor activation prevents human soluble amyloid beta (Abeta)-induced impairment of long-term potentiation (LTP) in …
Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington's Disease.
Ayton S, Lei P, Appukuttan AT, Renoir T, Foliaki S, Chen F, Adlard PA, Hannan AJ, Bush AI. Ayton S, et al. Among authors: bush ai. Neurotherapeutics. 2020 Jan;17(1):243-251. doi: 10.1007/s13311-019-00785-6. Neurotherapeutics. 2020. PMID: 31520307 Free PMC article.
Low cortical zinc has been shown to induce cognitive impairment, and indeed, dietary restriction of zinc in R6/1 mice was associated with cognitive impairment in the Y-maze, an exacerbated hippocampal long-term potentiation (LTP) deficit and reduction of AMPA receptors (an …
Low cortical zinc has been shown to induce cognitive impairment, and indeed, dietary restriction of zinc in R6/1 mice was associated with co …
Extracellular Zn2+-independently attenuated LTP by human amyloid β1-40 and rat amyloid β1-42.
Tamano H, Takiguchi M, Shimaya R, Adlard PA, Bush AI, Takeda A. Tamano H, et al. Among authors: bush ai. Biochem Biophys Res Commun. 2019 Jun 30;514(3):888-892. doi: 10.1016/j.bbrc.2019.05.037. Epub 2019 May 10. Biochem Biophys Res Commun. 2019. PMID: 31084925
Here we report extracellular Zn(2+)-independent attenuation of dentate gyrus long-term potentiation (LTP) by human Abeta(1-40) and rat Abeta(1-42). ...
Here we report extracellular Zn(2+)-independent attenuation of dentate gyrus long-term potentiation (LTP) by human Abeta(1-40) and ra …
Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica?
Bray L, Volitakis I, Ayton S, Bush AI, Adlard PA. Bray L, et al. Among authors: bush ai. Nutrients. 2019 Jan 21;11(1):206. doi: 10.3390/nu11010206. Nutrients. 2019. PMID: 30669644 Free PMC article.
These data suggest that Zn-DTSM, or similar compounds, should be further explored as potential therapeutic options for the long-term treatment of AE....
These data suggest that Zn-DTSM, or similar compounds, should be further explored as potential therapeutic options for the long-term …
Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology.
Diouf I, Fazlollahi A, Bush AI, Ayton S; Alzheimer's disease Neuroimaging Initiative. Diouf I, et al. Among authors: bush ai. Neurobiol Dis. 2019 Apr;124:335-339. doi: 10.1016/j.nbd.2018.12.010. Epub 2018 Dec 14. Neurobiol Dis. 2019. PMID: 30557658
These data implicate iron as a contributing factor to neurodegeneration associated with beta-amyloid pathology, and highlight CSF ferritin as a complementary prognostic biomarker to the t-tau/Abeta(42) ratio that predicts near-term risk for disease progression....
These data implicate iron as a contributing factor to neurodegeneration associated with beta-amyloid pathology, and highlight CSF ferritin a …
Amyloid β1-42-Induced Rapid Zn2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia.
Tamano H, Suzuki H, Murakami T, Fujii H, Adlard PA, Bush AI, Takeda A. Tamano H, et al. Among authors: bush ai. Mol Neurobiol. 2019 Jul;56(7):5041-5050. doi: 10.1007/s12035-018-1429-6. Epub 2018 Nov 20. Mol Neurobiol. 2019. PMID: 30460616
On the basis of the evidence that amyloid beta(1-42) (Abeta(1-42))-induced Zn(2+) influx affects memory acquisition via attenuated long-term potentiation (LTP) induction, here we tested whether Abeta(1-42)-induced Zn(2+) influx affects maintained LTP in freely moving rats, …
On the basis of the evidence that amyloid beta(1-42) (Abeta(1-42))-induced Zn(2+) influx affects memory acquisition via attenuated long-t …
28 results