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Social determinants of respiratory health from birth: still of concern in the 21st century?
Bush A, Byrnes CA, Chan KC, Chang AB, Ferreira JC, Holden KA, Lovinsky-Desir S, Redding G, Singh V, Sinha IP, Zar HJ. Bush A, et al. Eur Respir Rev. 2024 Apr 10;33(172):230222. doi: 10.1183/16000617.0222-2023. Print 2024 Apr 30. Eur Respir Rev. 2024. PMID: 38599675 Free PMC article. Review.
Respiratory symptoms are ubiquitous in children and, even though they may be the harbinger of poor long-term outcomes, are often trivialised. Adverse exposures pre-conception, antenatally and in early childhood have lifetime impacts on respiratory health. ...
Respiratory symptoms are ubiquitous in children and, even though they may be the harbinger of poor long-term outcomes, are often triv …
A guideline on the molecular ecosystem regulating ferroptosis.
Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D. Dai E, et al. Among authors: bush ai. Nat Cell Biol. 2024 Feb 29. doi: 10.1038/s41556-024-01360-8. Online ahead of print. Nat Cell Biol. 2024. PMID: 38424270 Review.
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mech …
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest …
Time-dependent gene-environment interactions are essential drivers of asthma initiation and persistence.
Chatziparasidis G, Chatziparasidi MR, Kantar A, Bush A. Chatziparasidis G, et al. Among authors: bush a. Pediatr Pulmonol. 2024 Feb 21. doi: 10.1002/ppul.26935. Online ahead of print. Pediatr Pulmonol. 2024. PMID: 38380964
Herein, we introduce the importance of the time variant in asthma pathogenesis and emphasize the long-term clinical significance of the time-dependent gene-environment interactions in childhood....
Herein, we introduce the importance of the time variant in asthma pathogenesis and emphasize the long-term clinical significance of t …
Why and how should children be protected from the deluge of vaping related media and marketing overexposure?
White D, Bush A, Smyth AR, Bhatt JM. White D, et al. Among authors: bush a. Breathe (Sheff). 2023 Dec;19(4):230141. doi: 10.1183/20734735.0141-2023. Epub 2023 Dec 19. Breathe (Sheff). 2023. PMID: 38125806 Free PMC article. Review.
E-liquids used for e-cigarettes contain a wide range of harmful substances, and the clinical consequences of this are now being increasingly demonstrated, such as the rise in cases of e-cigarette- or vaping-associated lung injury. In addition, early use may result in long-term …
E-liquids used for e-cigarettes contain a wide range of harmful substances, and the clinical consequences of this are now being increasingly …
Learning from cystic fibrosis: How can we start to personalise treatment of Children's Interstitial Lung Disease (chILD)?
Bush A. Bush A. Paediatr Respir Rev. 2023 Nov 19:S1526-0542(23)00078-7. doi: 10.1016/j.prrv.2023.11.001. Online ahead of print. Paediatr Respir Rev. 2023. PMID: 37996258 Free article. Review.
This has come about by discovering the detailed biology of the different CF molecular sub-endotypes; the development of biomarkers to assess response even in mild disease or young children; the performance of definitive large randomised controlled trials in patients with a common …
This has come about by discovering the detailed biology of the different CF molecular sub-endotypes; the development of biomarkers to assess …
Novel community data in ecology-properties and prospects.
Hartig F, Abrego N, Bush A, Chase JM, Guillera-Arroita G, Leibold MA, Ovaskainen O, Pellissier L, Pichler M, Poggiato G, Pollock L, Si-Moussi S, Thuiller W, Viana DS, Warton DI, Zurell D, Yu DW. Hartig F, et al. Among authors: bush a. Trends Ecol Evol. 2024 Mar;39(3):280-293. doi: 10.1016/j.tree.2023.09.017. Epub 2023 Nov 8. Trends Ecol Evol. 2024. PMID: 37949795 Review.
New technologies for monitoring biodiversity such as environmental (e)DNA, passive acoustic monitoring, and optical sensors promise to generate automated spatiotemporal community observations at unprecedented scales and resolutions. Here, we introduce 'novel community data' as an …
New technologies for monitoring biodiversity such as environmental (e)DNA, passive acoustic monitoring, and optical sensors promise to gener …
Advances in the pathogenesis and personalised treatment of paediatric asthma.
Scotney E, Fleming L, Saglani S, Sonnappa S, Bush A. Scotney E, et al. Among authors: bush a. BMJ Med. 2023 Jun 25;2(1):e000367. doi: 10.1136/bmjmed-2022-000367. eCollection 2023. BMJ Med. 2023. PMID: 37841968 Free PMC article. Review.
The diversity of pathology of severe paediatric asthma demonstrates that the one-size-fits-all approach characterising many guidelines is inappropriate. The term "asthma" is best used to describe a clinical syndrome of wheeze, chest tightness, breathlessness, and sometimes …
The diversity of pathology of severe paediatric asthma demonstrates that the one-size-fits-all approach characterising many guidelines is in …
Patient financial incentives to improve asthma management: a systematic review.
Hine J, Lee B, Bush A, De Simoni A, Griffiths C, Judah G, Fleming L. Hine J, et al. Among authors: bush a. BMJ Open. 2023 Jul 30;13(7):e070761. doi: 10.1136/bmjopen-2022-070761. BMJ Open. 2023. PMID: 37518086 Free PMC article.
OBJECTIVES: The objectives of this systematic review are to identify studies that assess the effectiveness of patient-directed financial incentive interventions to improve asthma management behaviours, determine overall effectiveness of financial incentives, identify design chara …
OBJECTIVES: The objectives of this systematic review are to identify studies that assess the effectiveness of patient-directed financial inc …
Airway epithelial development and function: A key player in asthma pathogenesis?
Chatziparasidis G, Bush A, Chatziparasidi MR, Kantar A. Chatziparasidis G, et al. Among authors: bush a. Paediatr Respir Rev. 2023 Sep;47:51-61. doi: 10.1016/j.prrv.2023.04.005. Epub 2023 May 25. Paediatr Respir Rev. 2023. PMID: 37330410 Review.
The widespread use of inhaled steroids has dramatically improved asthma control but has offered nothing in terms of altering long-term outcomes or reversing airway remodeling and impairment in lung function. ...
The widespread use of inhaled steroids has dramatically improved asthma control but has offered nothing in terms of altering long-term …
Diffuse alveolar haemorrhage in children: an international multicentre study.
Ring AM, Schwerk N, Kiper N, Aslan AT, Aurora P, Ayats R, Azevedo I, Bandeira T, Carlens J, Castillo-Corullon S, Cobanoglu N, Elnazir B, Emiralioğlu N, Eyuboglu TS, Fayon M, Gursoy TR, Hogg C, Kötz K, Karadag B, Látalová V, Krenke K, Lange J, Manali ED, Osona B, Papiris S, Proesmann M, Reix P, Roditis L, Rubak S, Rumman N, Snijders D, Stehling F, Weiss L, Yalcın E, Zirek F, Bush A, Clement A, Griese M, Buchvald FF, Nathan N, Nielsen KG. Ring AM, et al. Among authors: bush a. ERJ Open Res. 2023 Apr 24;9(2):00733-2022. doi: 10.1183/23120541.00733-2022. eCollection 2023 Mar. ERJ Open Res. 2023. PMID: 37101741 Free PMC article.
The most frequent medical treatment was systemic corticosteroids (93%), hydroxychloroquine (35%) and azathioprine (27%). Overall mortality was 13%. Long-term data demonstrated persistent abnormal radiology and a limited improvement in lung function. ...This large internati …
The most frequent medical treatment was systemic corticosteroids (93%), hydroxychloroquine (35%) and azathioprine (27%). Overall mortality w …
152 results