An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
Nacke M, Sandilands E, Nikolatou K, Román-Fernández Á, Mason S, Patel R, Lilla S, Yelland T, Galbraith LCA, Freckmann EC, McGarry L, Morton JP, Shanks E, Leung HY, Markert E, Ismail S, Zanivan S, Blyth K, Bryant DM.
Nacke M, et al. Among authors: bryant dm.
Nat Commun. 2021 Mar 12;12(1):1623. doi: 10.1038/s41467-021-21847-4.
Nat Commun. 2021.
PMID: 33712589
Free PMC article.
Induction of pro-invasive IQSEC1 variants and elevated IQSEC1 expression occurs in a number of tumour types and is associated with higher-grade metastatic cancer, activation of PI(3,4,5)P(3) signalling, and predicts long-term poor outcome across multiple cancers. IQSEC1-re …
Induction of pro-invasive IQSEC1 variants and elevated IQSEC1 expression occurs in a number of tumour types and is associated with higher-gr …