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Xeno Amino Acids: A Look into Biochemistry as We Do Not Know It.
Brown SM, Mayer-Bacon C, Freeland S. Brown SM, et al. Life (Basel). 2023 Nov 29;13(12):2281. doi: 10.3390/life13122281. Life (Basel). 2023. PMID: 38137883 Free PMC article. Review.
Exciting opportunities now present themselves for laboratory work and computing to explore how changing the amino acid alphabet alters the universe of protein folds. Near-term milestones include: (a) expanding evidence about amino acids as attractors within chemical evolut …
Exciting opportunities now present themselves for laboratory work and computing to explore how changing the amino acid alphabet alters the u …
Modifiable in-hospital factors for 12-month global cognition, post-traumatic stress disorder symptoms, and depression symptoms in adults hospitalized with COVID-19.
Han JH, Jackson JC, Orun OM, Brown SM, Casey JD, Clark L, Collins SP, Cordero K, Ginde AA, Gong MN, Hough CL, Iwashyna TJ, Kiehl AL, Lauck A, Leither LM, Lindsell CJ, Patel MB, Raman R, Rice TW, Ringwood NJ, Sheppard KL, Semler MW, Thompson BT, Ely EW, Self WH; National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. Han JH, et al. Among authors: brown sm. Influenza Other Respir Viruses. 2023 Sep;17(9):e13197. doi: 10.1111/irv.13197. Influenza Other Respir Viruses. 2023. PMID: 37752063 Free PMC article.
CONCLUSION: Potentially modifiable factors associated with better long-term outcomes included remdesivir use (associated with better cognitive function), avoidance of delirium (associated with less PTSD and depression symptoms), and increased virtual interactions with frie …
CONCLUSION: Potentially modifiable factors associated with better long-term outcomes included remdesivir use (associated with better …
Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial.
Williams Roberson S, Nwosu S, Collar EM, Kiehl AL, Harrison FE, Bastarache J, Wilson JE, Mart MF, Sevransky JE, Ely EW, Lindsell CJ, Jackson JC; VICTAS Investigators. Williams Roberson S, et al. JAMA Netw Open. 2023 Feb 1;6(2):e230380. doi: 10.1001/jamanetworkopen.2023.0380. JAMA Netw Open. 2023. PMID: 36853612 Free PMC article. Clinical Trial.
IMPORTANCE: Sepsis is associated with long-term cognitive impairment and worse psychological and functional outcomes. ...These findings challenge the hypothesis that antioxidant and anti-inflammatory therapy during critical illness mitigates the development of long-term …
IMPORTANCE: Sepsis is associated with long-term cognitive impairment and worse psychological and functional outcomes. ...These findin …
Analytic modeling of neural tissue: II. Nonlinear membrane dynamics.
Schwartz BL, Brown SM, Muthuswamy J, Sadleir RJ. Schwartz BL, et al. Among authors: brown sm. AIP Adv. 2022 Nov 14;12(11):115019. doi: 10.1063/5.0124414. eCollection 2022 Nov. AIP Adv. 2022. PMID: 36397822 Free PMC article.
For each variable, we construct a power series solution equivalent to a generalized Taylor series expanded about a function. The first term of the decomposition series comes from the models' initial conditions. ...
For each variable, we construct a power series solution equivalent to a generalized Taylor series expanded about a function. The first te …
The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.
ACTIV-3/TICO Study Group; Rogers AJ, Wentworth D, Phillips A, Shaw-Saliba K, Dewar RL, Aggarwal NR, Babiker AG, Chang W, Dharan NJ, Davey VJ, Higgs ES, Gerry N, Ginde AA, Hayanga JWA, Highbarger H, Highbarger JL, Jain MK, Kan V, Kim K, Lallemand P, Leshnower BG, Lutaakome JK, Matthews G, Mourad A, Mylonakis E, Natarajan V, Padilla ML, Pandit LM, Paredes R, Pett S, Ramachandruni S, Rehman MT, Sherman BT, Files DC, Brown SM, Matthay MA, Thompson BT, Neaton JD, Lane HC, Lundgren JD. ACTIV-3/TICO Study Group, et al. Among authors: brown sm. Ann Intern Med. 2022 Oct;175(10):1401-1410. doi: 10.7326/M22-0924. Epub 2022 Aug 30. Ann Intern Med. 2022. PMID: 36037469 Free PMC article.
OBJECTIVE: To evaluate whether levels of plasma antigen can predict short-term clinical outcomes and identify clinical and viral factors associated with plasma antigen levels in hospitalized patients with SARS-CoV-2. ...
OBJECTIVE: To evaluate whether levels of plasma antigen can predict short-term clinical outcomes and identify clinical and viral fact …
Protection of Messenger RNA Vaccines Against Hospitalized Coronavirus Disease 2019 in Adults Over the First Year Following Authorization in the United States.
Tenforde MW, Self WH, Zhu Y, Naioti EA, Gaglani M, Ginde AA, Jensen K, Talbot HK, Casey JD, Mohr NM, Zepeski A, McNeal T, Ghamande S, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CL, Busse LW, Lohuis CT, Duggal A, Wilson JG, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Exline MC, Botros MM, Lauring AS, Shapiro NI, Halasa N, Chappell JD, Grijalva CG, Rice TW, Jones ID, Stubblefield WB, Baughman A, Womack KN, Rhoads JP, Lindsell CJ, Hart KW, Turbyfill C, Olson S, Murray N, Adams K, Patel MM; Influenza and Other Viruses in the Acutely Ill (IVY) Network. Tenforde MW, et al. Among authors: brown sm. Clin Infect Dis. 2023 Feb 8;76(3):e460-e468. doi: 10.1093/cid/ciac381. Clin Infect Dis. 2023. PMID: 35580849 Free PMC article.
Although vaccine effectiveness (VE) against mild infection declines markedly after several months, limited understanding exists on the long-term durability of protection against COVID-19-associated hospitalization. ...
Although vaccine effectiveness (VE) against mild infection declines markedly after several months, limited understanding exists on the long- …
Associations between childhood maltreatment and behavioral sleep disturbances across the lifespan: A systematic review.
Brown SM, Rodriguez KE, Smith AD, Ricker A, Williamson AA. Brown SM, et al. Sleep Med Rev. 2022 Aug;64:101621. doi: 10.1016/j.smrv.2022.101621. Epub 2022 Mar 5. Sleep Med Rev. 2022. PMID: 35367857 Free PMC article. Review.
Childhood maltreatment has a range of long-term developmental and health consequences. Emerging research suggests that sleep disturbances may be a key behavioral health risk factor implicated in the relationship between maltreatment and poor health across the lifespan. ... …
Childhood maltreatment has a range of long-term developmental and health consequences. Emerging research suggests that sleep disturba …
Association between unmet medication needs after hospital discharge and readmission or death among acute respiratory failure survivors: the addressing post-intensive care syndrome (APICS-01) multicenter prospective cohort study.
Brown SM, Dinglas VD, Akhlaghi N, Bose S, Banner-Goodspeed V, Beesley S, Groat D, Greene T, Hopkins RO, Mir-Kasimov M, Sevin CM, Turnbull AE, Jackson JC, Needham DM; APICS-01 Study Team. Brown SM, et al. Crit Care. 2022 Jan 7;26(1):6. doi: 10.1186/s13054-021-03848-3. Crit Care. 2022. PMID: 34991660 Free PMC article.
Adults Hospitalized With Coronavirus Disease 2019 (COVID-19)-United States, March-June and October-December 2020: Implications for the Potential Effects of COVID-19 Tier-1 Vaccination on Future Hospitalizations and Outcomes.
Sami S, Tenforde MW, Talbot HK, Lindsell CJ, Steingrub JS, Shapiro NI, Ginde AA, Douin DJ, Prekker ME, Erickson HL, Brown SM, Peltan ID, Gong MN, Khan A, Exline MC, Files DC, Gibbs KW, Rice TW, Casey JD, Grijalva CG, Stubblefield WB, Womack KN, Hager DN, Qadir N, Chang SY, Henning DJ, Wilson JG, Self WH, Patel MM. Sami S, et al. Among authors: brown sm. Clin Infect Dis. 2021 Jul 15;73(Suppl 1):S32-S37. doi: 10.1093/cid/ciab319. Clin Infect Dis. 2021. PMID: 33977301 Free PMC article.
BACKGROUND: Because of the increased risk for severe coronavirus disease 2019 (COVID-19), the Advisory Committee on Immunization Practices (ACIP) initially prioritized COVID-19 vaccination for persons in long-term care facilities (LTCF), persons aged 65 years, and persons …
BACKGROUND: Because of the increased risk for severe coronavirus disease 2019 (COVID-19), the Advisory Committee on Immunization Practices ( …
Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Among Hospitalized Adults Aged ≥65 Years - United States, January-March 2021.
Tenforde MW, Olson SM, Self WH, Talbot HK, Lindsell CJ, Steingrub JS, Shapiro NI, Ginde AA, Douin DJ, Prekker ME, Brown SM, Peltan ID, Gong MN, Mohamed A, Khan A, Exline MC, Files DC, Gibbs KW, Stubblefield WB, Casey JD, Rice TW, Grijalva CG, Hager DN, Shehu A, Qadir N, Chang SY, Wilson JG, Gaglani M, Murthy K, Calhoun N, Monto AS, Martin ET, Malani A, Zimmerman RK, Silveira FP, Middleton DB, Zhu Y, Wyatt D, Stephenson M, Baughman A, Womack KN, Hart KW, Kobayashi M, Verani JR, Patel MM; IVY Network; HAIVEN Investigators. Tenforde MW, et al. Among authors: brown sm. MMWR Morb Mortal Wkly Rep. 2021 May 7;70(18):674-679. doi: 10.15585/mmwr.mm7018e1. MMWR Morb Mortal Wkly Rep. 2021. PMID: 33956782 Free PMC article.
Among 417 hospitalized adults aged 65 years (including 187 case-patients and 230 controls), the median age was 73 years, 48% were female, 73% were non-Hispanic White, 17% were non-Hispanic Black, 6% were Hispanic, and 4% lived in a long-term care facility. Adjusted vaccine …
Among 417 hospitalized adults aged 65 years (including 187 case-patients and 230 controls), the median age was 73 years, 48% were female, 73 …
49 results