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Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol.
Attard G, Murphy L, Clarke NW, Sachdeva A, Jones C, Hoyle A, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Gilson C, Rush H, Abdel-Aty H, Amos CL, Murphy C, Chowdhury S, Malik Z, Russell JM, Parkar N, Pugh C, Diaz-Montana C, Pezaro C, Grant W, Saxby H, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzouebi M, Parikh O, Robinson A, Montazeri AH, Wylie J, Zarkar A, Cathomas R, Brown MD, Jain Y, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; STAMPEDE investigators. Attard G, et al. Among authors: brown md. Lancet Oncol. 2023 May;24(5):443-456. doi: 10.1016/S1470-2045(23)00148-1. Lancet Oncol. 2023. PMID: 37142371 Free article.
BACKGROUND: Abiraterone acetate plus prednisolone (herein referred to as abiraterone) or enzalutamide added at the start of androgen deprivation therapy improves outcomes for patients with metastatic prostate cancer. Here, we aimed to evaluate long-term outcomes and test w …
BACKGROUND: Abiraterone acetate plus prednisolone (herein referred to as abiraterone) or enzalutamide added at the start of androgen depriva …
Long-term voluntary wheel running effects on markers of long interspersed nuclear element-1 in skeletal muscle, liver, and brain tissue of female rats.
Osburn SC, Mesquita PHC, Neal FK, Rumbley MN, Holmes MT, Ruple BA, Mobley CB, Brown MD, McCullough DJ, Kavazis AN, Roberts MD. Osburn SC, et al. Among authors: brown md. Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C907-C919. doi: 10.1152/ajpcell.00234.2022. Epub 2022 Aug 8. Am J Physiol Cell Physiol. 2022. PMID: 35938680 Free article.
We sought to determine the effects of long-term voluntary wheel running on markers of long interspersed nuclear element-1 (L1) in skeletal muscle, liver, and the hippocampus of female rats. ...
We sought to determine the effects of long-term voluntary wheel running on markers of long interspersed nuclear element-1 (L1) in ske …
Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue.
Sachdeva A, Hart CA, Carey CD, Vincent AE, Greaves LC, Heer R, Oliveira P, Brown MD, Clarke NW, Turnbull DM. Sachdeva A, et al. Among authors: brown md. Sci Rep. 2022 Apr 22;12(1):6660. doi: 10.1038/s41598-022-10588-z. Sci Rep. 2022. PMID: 35459777 Free PMC article.
This methodology can now be applied more widely to study the frequency and distribution of OXPHOS alterations in formalin-fixed tissues, and their impact on long-term clinical outcomes....
This methodology can now be applied more widely to study the frequency and distribution of OXPHOS alterations in formalin-fixed tissues, and …
Effect of intervertebral disc degeneration on mechanical and electric signals at the interface between disc and vertebra.
Zhu Q, Gao X, Chen S, Gu W, Brown MD. Zhu Q, et al. Among authors: brown md. J Biomech. 2020 May 7;104:109756. doi: 10.1016/j.jbiomech.2020.109756. Epub 2020 Mar 16. J Biomech. 2020. PMID: 32248941 Free PMC article.
The objective of this study was to numerically investigate the long-term distributions of mechanical and electrical signals on the disc-vertebra interface with disc degeneration. ...
The objective of this study was to numerically investigate the long-term distributions of mechanical and electrical signals on the di …
Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS).
Newcomb LF, Zheng Y, Faino AV, Bianchi-Frias D, Cooperberg MR, Brown MD, Brooks JD, Dash A, Fabrizio MD, Gleave ME, Liss M, Morgan TM, Thompson IM, Wagner AA, Carroll PR, Nelson PS, Lin DW. Newcomb LF, et al. Among authors: brown md. Prostate Cancer Prostatic Dis. 2019 Sep;22(3):438-445. doi: 10.1038/s41391-018-0124-z. Epub 2019 Jan 21. Prostate Cancer Prostatic Dis. 2019. PMID: 30664734 Free PMC article.
The association of biomarker scores, adjusted for common clinical variables, with short- and long-term reclassification was evaluated. Discriminatory capacity of models with clinical variables alone or with biomarkers was assessed using receiver operating characteristic (R …
The association of biomarker scores, adjusted for common clinical variables, with short- and long-term reclassification was evaluated …
A cellular mechanism of muscle memory facilitates mitochondrial remodelling following resistance training.
Lee H, Kim K, Kim B, Shin J, Rajan S, Wu J, Chen X, Brown MD, Lee S, Park JY. Lee H, et al. Among authors: brown md. J Physiol. 2018 Sep;596(18):4413-4426. doi: 10.1113/JP275308. Epub 2018 Aug 12. J Physiol. 2018. PMID: 30099751 Free PMC article.
In the present study, we found that, when rats were subjected to physiologically relevant resistance training, the number of myonuclei increased and was retained during a long-term detraining period. The acquired myonuclei were related to a greater degree of muscle hypertr …
In the present study, we found that, when rats were subjected to physiologically relevant resistance training, the number of myonuclei incre …
Short-term regular aerobic exercise reduces oxidative stress produced by acute in the adipose microvasculature.
Robinson AT, Fancher IS, Sudhahar V, Bian JT, Cook MD, Mahmoud AM, Ali MM, Ushio-Fukai M, Brown MD, Fukai T, Phillips SA. Robinson AT, et al. Among authors: brown md. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H896-H906. doi: 10.1152/ajpheart.00684.2016. Epub 2017 Feb 24. Am J Physiol Heart Circ Physiol. 2017. PMID: 28235790 Free PMC article.
Emergency Department Management of Transient Ischemic Attack: A Survey of Emergency Physicians.
Oostema JA, Brown MD, Reeves M. Oostema JA, et al. Among authors: brown md. J Stroke Cerebrovasc Dis. 2016 Jun;25(6):1517-23. doi: 10.1016/j.jstrokecerebrovasdis.2016.02.028. Epub 2016 Mar 31. J Stroke Cerebrovasc Dis. 2016. PMID: 27041082
The ABCD(2) score had low acceptability among emergency medicine physicians and was rarely incorporated into practice (10.7%). Respondents identified a short-term risk of stroke of less than 2% (95% confidence interval: 1.6-2.4) as an acceptable threshold for discharge; ho …
The ABCD(2) score had low acceptability among emergency medicine physicians and was rarely incorporated into practice (10.7%). Respondents i …
Simulation of biological therapies for degenerated intervertebral discs.
Zhu Q, Gao X, Temple HT, Brown MD, Gu W. Zhu Q, et al. Among authors: brown md. J Orthop Res. 2016 Apr;34(4):699-708. doi: 10.1002/jor.23061. Epub 2015 Oct 13. J Orthop Res. 2016. PMID: 26425965 Free PMC article.
The cell number needed, nutrition level demanded, time required for the repair, and the long-term outcomes of these therapies were analyzed. For Case I, the repair process was predicted to be dependent on the cell density implanted and the nutrition level at disc boundarie …
The cell number needed, nutrition level demanded, time required for the repair, and the long-term outcomes of these therapies were an …
Simulation of the progression of intervertebral disc degeneration due to decreased nutritional supply.
Gu W, Zhu Q, Gao X, Brown MD. Gu W, et al. Among authors: brown md. Spine (Phila Pa 1976). 2014 Nov 15;39(24):E1411-7. doi: 10.1097/BRS.0000000000000560. Spine (Phila Pa 1976). 2014. PMID: 25188596 Free PMC article.
The simulated results for the distributions of PG and water contents within the disc were consistent with the results measured in the literature, except for the distribution of PG content in the sagittal direction. CONCLUSION: Poor nutritional supply has a long-term effect …
The simulated results for the distributions of PG and water contents within the disc were consistent with the results measured in the litera …
46 results