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Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
Bakker C, Tasker T, Liptrot J, Hart EP, Klaassen ES, Doll RJ, Brown GA, Brown A, Congreve M, Weir M, Marshall FH, Cross DM, Groeneveld GJ, Nathan PJ. Bakker C, et al. Among authors: brown ga. Alzheimers Res Ther. 2021 Apr 21;13(1):87. doi: 10.1186/s13195-021-00816-5. Alzheimers Res Ther. 2021. PMID: 33883008 Free PMC article. Clinical Trial.
HTL0018318 over the 10 days of treatment had significant effects on tests of short-term (working) memory (n-back) and learning (Milner maze) with moderate to large effect sizes. CONCLUSION: Multiple doses of HTL0018138 showed well-characterised pharmacokinetics and were sa …
HTL0018318 over the 10 days of treatment had significant effects on tests of short-term (working) memory (n-back) and learning (Milne …
Medication adherence decision-making among adolescents and young adults with cancer.
McGrady ME, Brown GA, Pai AL. McGrady ME, et al. Among authors: brown ga. Eur J Oncol Nurs. 2016 Feb;20:207-14. doi: 10.1016/j.ejon.2015.08.007. Epub 2015 Sep 12. Eur J Oncol Nurs. 2016. PMID: 26372619 Free PMC article.
Themes were generally consistent across medication regimens but differed with age, with older AYAs discussing long-term impacts and receiving physical support from their caregivers more than younger AYAs. ...
Themes were generally consistent across medication regimens but differed with age, with older AYAs discussing long-term impacts and r …
Development and validation of an instrument to predict functional recovery in tibial fracture patients: the Somatic Pre-Occupation and Coping (SPOC) questionnaire.
Busse JW, Bhandari M, Guyatt GH, Heels-Ansdell D, Kulkarni AV, Mandel S, Sanders D, Schemitsch E, Swiontkowski M, Tornetta P 3rd, Wai E, Walter SD; SPRINT Investigators & the Medically Unexplained Syndromes Study Group. Busse JW, et al. J Orthop Trauma. 2012 Jun;26(6):370-8. doi: 10.1097/BOT.0b013e31822421e2. J Orthop Trauma. 2012. PMID: 22011635 Free PMC article.
CONCLUSION: The SPOC questionnaire is a valid measurement of illness beliefs in patients with tibial fracture and is highly predictive of their long-term functional recovery. Future research should explore if these results extend to other trauma populations and if modifica …
CONCLUSION: The SPOC questionnaire is a valid measurement of illness beliefs in patients with tibial fracture and is highly predictive of th …
The role of radical cystectomy in patients with clinical T4b bladder cancer.
Black PC, Dinney CP, Brown GA, Kassouf W, Siefker-Radtke AO, Munsell MF, Grossman HB, Kamat AM. Black PC, et al. Among authors: brown ga. Urol Oncol. 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.urolonc.2009.12.015. Epub 2010 Apr 24. Urol Oncol. 2011. PMID: 20456984 Free PMC article.
Variant histology was more common in this cohort than in the overall cystectomy database (43% vs. 11%). CONCLUSIONS: Long-term survival can be achieved in a proportion of patients with cT4b bladder cancer undergoing chemotherapy and extirpative surgery. ...
Variant histology was more common in this cohort than in the overall cystectomy database (43% vs. 11%). CONCLUSIONS: Long-term surviv …
Self-reported dietary intake following endurance, resistance and concurrent endurance and resistance training.
Shaw BS, Shaw I, Brown GA. Shaw BS, et al. Among authors: brown ga. J Sports Sci Med. 2008 Jun 1;7(2):255-9. eCollection 2008. J Sports Sci Med. 2008. PMID: 24149458 Free PMC article.
It is concluded that concurrent aerobic and weight training is the most effective mode of exercise at promoting a favourable improvement in self-reported dietary intake in the short term. This finding provides support for efforts to promote increases in overall physical ac …
It is concluded that concurrent aerobic and weight training is the most effective mode of exercise at promoting a favourable improvement in …
A current review of medical therapy for benign prostatic hyperplasia.
Brown GA, Sussman DO. Brown GA, et al. J Am Osteopath Assoc. 2004 Feb;104(2 Suppl 2):S11-6. J Am Osteopath Assoc. 2004. PMID: 15038398
Therapy for this disease has evolved considerably from its inception. Recent data from long-term population-based studies have shed new light on the treatment of this common problem in aging men. ...
Therapy for this disease has evolved considerably from its inception. Recent data from long-term population-based studies have shed n …
Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization.
Grant MB, May WS, Caballero S, Brown GA, Guthrie SM, Mames RN, Byrne BJ, Vaught T, Spoerri PE, Peck AB, Scott EW. Grant MB, et al. Among authors: brown ga. Nat Med. 2002 Jun;8(6):607-12. doi: 10.1038/nm0602-607. Nat Med. 2002. PMID: 12042812
Adult mice were durably engrafted with hematopoietic stem cells isolated from transgenic mice expressing green fluorescent protein. We performed serial long-term transplants, to ensure activity arose from self-renewing stem cells, and single hematopoietic stem-cell transpl …
Adult mice were durably engrafted with hematopoietic stem cells isolated from transgenic mice expressing green fluorescent protein. We perfo …
Rnx deficiency results in congenital central hypoventilation.
Shirasawa S, Arata A, Onimaru H, Roth KA, Brown GA, Horning S, Arata S, Okumura K, Sasazuki T, Korsmeyer SJ. Shirasawa S, et al. Among authors: brown ga. Nat Genet. 2000 Mar;24(3):287-90. doi: 10.1038/73516. Nat Genet. 2000. PMID: 10700185
To determine the developmental role of Rnx, we disrupted the locus in mouse embryonic stem (ES) cells. Rnx deficient mice developed to term, but all died within 24 hours after birth from a central respiratory failure. ...
To determine the developmental role of Rnx, we disrupted the locus in mouse embryonic stem (ES) cells. Rnx deficient mice developed to te …
Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial.
King DS, Sharp RL, Vukovich MD, Brown GA, Reifenrath TA, Uhl NL, Parsons KA. King DS, et al. Among authors: brown ga. JAMA. 1999 Jun 2;281(21):2020-8. doi: 10.1001/jama.281.21.2020. JAMA. 1999. PMID: 10359391 Clinical Trial.
However, whether androstenedione actually increases blood testosterone levels or produces anabolic androgenic effects is not known. OBJECTIVES: To determine if short- and long-term oral androstenedione supplementation in men increases serum testosterone levels and skeletal …
However, whether androstenedione actually increases blood testosterone levels or produces anabolic androgenic effects is not known. OBJECTIV …
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